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Fancb Gene Detail
Summary
  • Symbol
    Fancb
  • Name
    Fanconi anemia, complementation group B
  • Synonyms
    MGC:31411
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448558
    NCBI Gene: 237211
  • Gene Overview
    MyGene.info: FANCB
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:164980592-164997272 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 76.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448558
protein coding gene ChrX:164980524-164997272 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036260
protein coding gene ChrX:163097409-163114916 (+)
A/J MGP_AJ_G0036230
protein coding gene ChrX:162233185-162249861 (+)
AKR/J MGP_AKRJ_G0036158
protein coding gene ChrX:167469747-167486423 (+)
BALB/cJ MGP_BALBcJ_G0036223
protein coding gene ChrX:160241752-160261388 (+)
C3H/HeJ MGP_C3HHeJ_G0035930
protein coding gene ChrX:163421049-163437475 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036746
protein coding gene ChrX:167865610-167883457 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033566
protein coding gene ChrX:153252103-153268096 (+)
CAST/EiJ MGP_CASTEiJ_G0035218
protein coding gene ChrX:142369954-142390318 (+)
CBA/J MGP_CBAJ_G0035904
protein coding gene ChrX:172755730-172772525 (+)
DBA/2J MGP_DBA2J_G0036070
protein coding gene ChrX:161110127-161126618 (+)
FVB/NJ MGP_FVBNJ_G0036002
protein coding gene ChrX:160244149-160260696 (+)
LP/J MGP_LPJ_G0036155
protein coding gene ChrX:164217479-164235288 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036034
protein coding gene ChrX:181436237-181454290 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036785
protein coding gene ChrX:162579500-162598224 (+)
PWK/PhJ MGP_PWKPhJ_G0034916
protein coding gene ChrX:139154589-139171667 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034737
protein coding gene ChrX:142881339-142898453 (+)
WSB/EiJ MGP_WSBEiJ_G0035353
protein coding gene ChrX:160518988-160536032 (+)



Homology
more
  • Human Ortholog
    FANCB, FA complementation group B
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FANCB, FA complementation group B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FA2, FAAP90, FAAP95, FAB, FACB
  • Links
    NCBI Gene ID: 2187
    neXtProt AC: NX_Q8NB91
    UniProt: Q8NB91

  • Chr Location
    Xp22.2; chrX:14690863-14873255 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 51880
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FANCB
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human FANCB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male infertility with oligozoospermia, reduced primordial germ cells and defects in the maintenance of undifferentiated spermatogonia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047757 Ensembl Gene Model | MGI Sequence Detail 16681 C57BL/6J ±  kb
transcript ENSMUST00000101082 Ensembl | MGI Sequence Detail 2980 Not Applicable  
polypeptide ENSMUSP00000098643 Ensembl | MGI Sequence Detail 862 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR033333 Fanconi anemia group B protein
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:240753 Alavattam KG, et al., Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications. Cell Rep. 2016 Oct 18;17(4):1141-1157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory