Nim1k MGI Mouse Gene Detail - MGI:2442399 - NIM1 serine/threonine protein kinase

Symbol

Nim1k
Name

NIM1 serine/threonine protein kinase
Synonyms

E130304F04Rik, Nim1

Feature Type

protein coding gene
IDs

MGI:2442399
NCBI Gene: 245269
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:119710094-119755882 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, Syntenic

SNPs within 2kb

412 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442399	protein coding gene	Chr13:119710094-119755882 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020977	protein coding gene	Chr13:122653781-122701361 (-)
A/J	MGP_AJ_G0020927	protein coding gene	Chr13:117780504-117830478 (-)
AKR/J	MGP_AKRJ_G0020902	protein coding gene	Chr13:121238711-121285631 (-)
BALB/cJ	MGP_BALBcJ_G0020927	protein coding gene	Chr13:118344222-118393654 (-)
C3H/HeJ	MGP_C3HHeJ_G0020715	protein coding gene	Chr13:121096252-121143583 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021363	protein coding gene	Chr13:126335490-126381324 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018932	protein coding gene	Chr13:112616457-112663779 (-)
CAST/EiJ	MGP_CASTEiJ_G0020236	protein coding gene	Chr13:120846423-120900798 (-)
CBA/J	MGP_CBAJ_G0020678	protein coding gene	Chr13:131078920-131130768 (-)
DBA/2J	MGP_DBA2J_G0020801	protein coding gene	Chr13:117257787-117303869 (-)
FVB/NJ	MGP_FVBNJ_G0020785	protein coding gene	Chr13:115867883-115913566 (-)
LP/J	MGP_LPJ_G0020878	protein coding gene	Chr13:122724474-122770038 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020811	protein coding gene	Chr13:131878182-131927155 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021398	protein coding gene	Chr13:120860698-120905893 (-)
PWK/PhJ	MGP_PWKPhJ_G0019988	protein coding gene	Chr13:116141024-116186811 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019810	protein coding gene	Chr13:117005574-117056782 (-)
WSB/EiJ	MGP_WSBEiJ_G0020294	protein coding gene	Chr13:121463177-121510285 (-)

Human Ortholog

NIM1K, NIM1 serine/threonine protein kinase

Vertebrate Orthologs

10

Human Ortholog

NIM1K, NIM1 serine/threonine protein kinase
Orthology source: HomoloGene, HGNC
Synonyms

NIM1
Links

HGNC:28646

NCBI Gene ID: 167359

neXtProt AC: NX_Q8IY84

UniProt: Q8IY84
Chr Location

5p12; chr5:43192054-43280850 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 25286
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NIM1K
Gene Tree

Nim1k

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

1
Gene trapped

1
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

643
Tissues

8
cDNA Data

21
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nim1k

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Nim1k interacts with 364 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS56902.1
UniGene

403943

Ensembl

ENSMUSG00000095930 (Evidence)
NCBI Gene

245269

			Length	Strain/Species	Flank
genomic	245269	NCBI Gene Model \| MGI Sequence Detail	45789	C57BL/6J	± kb
transcript	NM_175538	RefSeq \| MGI Sequence Detail	4103	C57BL/6
polypeptide	Q8BHI9	UniProt \| EBI \| MGI Sequence Detail	436	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011211 serine/threonine-protein kinase NIM1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 22

cDNA 22

Microarray probesets 2

Summaries

All 24

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 4
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

TSS for Nim1k:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4207	Chr13:119755968-119756035 (-)	-120 bp
Tssr4206	Chr13:119755944-119755958 (-)	-69 bp
Tssr4205	Chr13:119755844-119755909 (-)	5 bp
Tssr4204	Chr13:119755813-119755826 (-)	62 bp
Tssr4201	Chr13:119728413-119728420 (-)	27,465 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/10/2020 MGI 6.16