About   Help   FAQ
Take the Alliance for Genomic Resources User Survey
Pank3 Gene Detail
Summary
  • Symbol
    Pank3
  • Name
    pantothenate kinase 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2387464
    NCBI Gene: 211347
Location & Maps
more
  • Sequence Map
    Chr11:35769484-35791285 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      21802 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 21.96 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PANK3, pantothenate kinase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PANK3, pantothenate kinase 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 79646
    neXtProt AC: NX_Q9H999

  • Chr Location
    5q34; chr5:168555623-168579609 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    15 phenotype references
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Targeted
    5
  • Genomic Mutations
    1 involving Pank3
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a knock-out allele in combination with either a knock-out of Pank1 or Pank2 exhibit complete embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    107
  • Tissues
    102
  • cDNA Data
    206
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005412 VEGA Gene Model | MGI Sequence Detail 21802 C57BL/6J ±  kb
transcript OTTMUST00000012065 VEGA | MGI Sequence Detail 7376 Not Applicable  
polypeptide OTTMUSP00000005591 VEGA | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    36 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 208
    cDNA 207
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:78668 Zhou B, et al., A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome. Nat Genet. 2001 Aug;28(4):345-9
  • Latest
    J:232556 Bao J, et al., UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genet. 2016 May;12(5):e1005863
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory