Pank3 MGI Mouse Gene Detail - MGI:2387464

Symbol

Pank3
Name

pantothenate kinase 3

Feature Type

protein coding gene
IDs

MGI:2387464
NCBI Gene: 211347
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:35769495-35791285 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 21.96 cM
Mapping Data

1 experiment

SNPs within 2kb

36 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2387464	protein coding gene	Chr11:35769484-35791285 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018155	protein coding gene	Chr11:34178713-34200524 (+)
A/J	MGP_AJ_G0018128	protein coding gene	Chr11:32895101-32918015 (+)
AKR/J	MGP_AKRJ_G0018092	protein coding gene	Chr11:33886533-33908216 (+)
BALB/cJ	MGP_BALBcJ_G0018097	protein coding gene	Chr11:33058601-33080562 (+)
C3H/HeJ	MGP_C3HHeJ_G0017910	protein coding gene	Chr11:33840891-33864093 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018551	protein coding gene	Chr11:35219835-35241650 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016206	protein coding gene	Chr11:31349539-31371540 (+)
CAST/EiJ	MGP_CASTEiJ_G0017474	protein coding gene	Chr11:33830734-33852139 (+)
CBA/J	MGP_CBAJ_G0017883	protein coding gene	Chr11:36906268-36927967 (+)
DBA/2J	MGP_DBA2J_G0017993	protein coding gene	Chr11:32639991-32661645 (+)
FVB/NJ	MGP_FVBNJ_G0017987	protein coding gene	Chr11:32490114-32512295 (+)
LP/J	MGP_LPJ_G0018065	protein coding gene	Chr11:34387313-34410148 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018011	protein coding gene	Chr11:37628151-37652580 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018590	protein coding gene	Chr11:33911557-33934922 (+)
PWK/PhJ	MGP_PWKPhJ_G0017255	protein coding gene	Chr11:32726565-32748425 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017047	protein coding gene	Chr11:33680144-33701897 (+)
WSB/EiJ	MGP_WSBEiJ_G0017523	protein coding gene	Chr11:33683480-33705092 (+)

Human Ortholog

PANK3, pantothenate kinase 3

Vertebrate Orthologs

9

Human Ortholog

PANK3, pantothenate kinase 3
Orthology source: HomoloGene, HGNC
Links

HGNC:19365

NCBI Gene ID: 79646

neXtProt AC: NX_Q9H999

UniProt: Q9H999
Chr Location

5q34; chr5:168555623-168579609 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56999
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PANK3
Protein SuperFamily

pantothenate kinase, acetyl-CoA regulated, stand-alone type
Gene Tree

Pank3

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Gene trapped

10
Targeted

5
Genomic Mutations

1 involving Pank3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele in combination with either a knock-out of Pank1 or Pank2 exhibit complete embryonic lethality.

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All GO Annotations

19
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

102
cDNA Data

207
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pank3

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Pank3 interacts with 455 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

49
RefSeq

2
UniProt

5
CCDS

CCDS24543.1
UniGene

255044

Ensembl

ENSMUSG00000018846 (Evidence)
NCBI Gene

211347

			Length	Strain/Species	Flank
genomic	211347	NCBI Gene Model \| MGI Sequence Detail	21791	C57BL/6J	± kb
transcript	NM_145962	RefSeq \| MGI Sequence Detail	7365	C57BL/6
polypeptide	Q8R2W9	UniProt \| EBI \| MGI Sequence Detail	370	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000012257 pantothenate kinase 3

(term hierarchy)
EC

2.7.1.33
InterPro Domains

IPR043129 ATPase, nucleotide binding domain

IPR004567 Type II pantothenate kinase

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All nucleic 209

cDNA 208

Primer pair 1

Microarray probesets 6

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:232556 Bao J, et al., UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts. PLoS Genet. 2016 May;12(5):e1005863

TSS for Pank3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100944	Chr11:35769374-35769404 (+)	-106 bp
Tssr100945	Chr11:35769462-35769475 (+)	-26 bp
Tssr100946	Chr11:35769574-35769616 (+)	100 bp
Tssr100947	Chr11:35769621-35769652 (+)	142 bp
Tssr100948	Chr11:35769807-35769819 (+)	318 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/16/2021 MGI 6.16