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Slc29a4
Gene Detail
Symbol

Name
ID
Slc29a4
solute carrier family 29 (nucleoside transporters), member 4
MGI:2385330
Synonyms
ENT4, mPMAT
Feature Type
protein coding gene
Genetic Map
Chromosome 5
81.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:142702101-142722490 bp, + strand
From Ensembl annotation of GRCm38

  20390 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:71345  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SLC29A4
Gene Tree: Slc29a4

Human
homologs
SLC29A4, solute carrier family 29 (equilibrative nucleoside transporter), member 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 222962
neXtProt AC: NX_Q7RTT9

Human Synonyms: ENT4, PMAT

Human Chr (Location): 7p22.1; chr7:5274374-5304073 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit impaired organic cation and monoamine uptake in the choroid plexus.
 
Interactions
Slc29a4 interacts with 150 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (7)    Tissues (1)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000050822 (Evidence)
Entrez Gene 243328 (Evidence)
UniGene 125942
DFCI TC1584132
DoTS DT.55253797
NIA Mouse Gene Index U076853
Consensus CDS Project CCDS39364.1
International Mouse Phenotyping Consortium Status Slc29a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050822 Ensembl Gene Model | MGI Sequence Detail 20390 C57BL/6J ±  kb
transcript ENSMUST00000058418 Ensembl | MGI Sequence Detail 2789 Not Applicable 
polypeptide ENSMUSP00000059896 Ensembl | MGI Sequence Detail 528 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002259 Equilibrative nucleoside transporter
InterPro IPR020846 Major facilitator superfamily domain
Protein Ontology PR:000015057 equilibrative nucleoside transporter 4
References
(Earliest) J:80848 Acimovic Y, et al., Molecular evolution of the equilibrative nucleoside transporter family: identification of novel family members in prokaryotes and eukaryotes. Mol Biol Evol. 2002 Dec;19(12):2199-210
(Latest) J:195656 Duan H, et al., Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4) gene. J Biol Chem. 2013 Feb 1;288(5):3535-44
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory