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Slc29a4 Gene Detail
Summary
  • Symbol
    Slc29a4
  • Name
    solute carrier family 29 (nucleoside transporters), member 4
  • Synonyms
    ENT4, mPMAT
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385330
    NCBI Gene: 243328
  • Gene Overview
    MyGene.info: SLC29A4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142692512-142722490 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 81.56 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385330
protein coding gene Chr5:142692478-142722490 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030316
protein coding gene Chr5:147948651-147994315 (+)
A/J MGP_AJ_G0030285
protein coding gene Chr5:141611321-141649533 (+)
AKR/J MGP_AKRJ_G0030217
protein coding gene Chr5:146026392-146059199 (+)
BALB/cJ MGP_BALBcJ_G0030302
protein coding gene Chr5:142857638-142889140 (+)
C3H/HeJ MGP_C3HHeJ_G0030013
protein coding gene Chr5:146855505-146890345 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030747
protein coding gene Chr5:153362060-153395617 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027965
protein coding gene Chr5:135429922-135459762 (+)
CAST/EiJ MGP_CASTEiJ_G0029418
protein coding gene Chr5:146320082-146352820 (+)
CBA/J MGP_CBAJ_G0029983
protein coding gene Chr5:159637977-159677528 (+)
DBA/2J MGP_DBA2J_G0030133
protein coding gene Chr5:141386763-141417469 (+)
FVB/NJ MGP_FVBNJ_G0030088
protein coding gene Chr5:140580635-140612793 (+)
LP/J MGP_LPJ_G0030219
protein coding gene Chr5:148572217-148602328 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030119
protein coding gene Chr5:162130880-162164461 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030787
protein coding gene Chr5:145879418-145913130 (+)
PWK/PhJ MGP_PWKPhJ_G0029133
protein coding gene Chr5:140458870-140490061 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028969
protein coding gene Chr5:143637131-143673939 (+)
WSB/EiJ MGP_WSBEiJ_G0029492
protein coding gene Chr5:146680372-146711728 (+)



Homology
more
  • Human Ortholog
    SLC29A4, solute carrier family 29 member 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC29A4, solute carrier family 29 member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ENT4, PMAT
  • Links
    NCBI Gene ID: 222962
    neXtProt AC: NX_Q7RTT9
    UniProt: Q7RTT9

  • Chr Location
    7p22.1; chr7:5274311-5304073 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired organic cation and monoamine uptake in the choroid plexus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050822 Ensembl Gene Model | MGI Sequence Detail 29979 C57BL/6J ±  kb
    transcript ENSMUST00000058418 Ensembl | MGI Sequence Detail 2789 Not Applicable  
    polypeptide ENSMUSP00000059896 Ensembl | MGI Sequence Detail 528 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:80848 Acimovic Y, et al., Molecular evolution of the equilibrative nucleoside transporter family: identification of novel family members in prokaryotes and eukaryotes. Mol Biol Evol. 2002 Dec;19(12):2199-210
    • Latest
      J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory