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Cdc73 Gene Detail
Summary
  • Symbol
    Cdc73
  • Name
    cell division cycle 73, Paf1/RNA polymerase II complex component
  • Synonyms
    8430414L16Rik, C130030P16Rik, Hrpt2, MGC:29274, MGC:36559
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384876
    NCBI Gene: 214498
  • Gene Overview
    MyGene.info: CDC73
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:143598800-143702893 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      104094 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 62.52 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CDC73, cell division cycle 73
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDC73, cell division cycle 73
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX
  • Links
    NCBI Gene ID: 79577
    neXtProt AC: NX_Q6P1J9
    UniProt: Q6P1J9

  • Chr Location
    1q31.2; chr1:193121958-193254815 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11571
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CDC73
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Cdc73 mouse models; 1 with human CDC73 associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 3 alleles in 5 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality around hatching or implantation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030974 VEGA Gene Model | MGI Sequence Detail 104094 C57BL/6J ±  kb
    transcript OTTMUST00000076702 VEGA | MGI Sequence Detail 11586 Not Applicable  
    polypeptide OTTMUSP00000040421 VEGA | MGI Sequence Detail 531 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      462 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1922999, MGI:2138700, MGI:2444564
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:255172 Droscha CJ, et al., Osteoblast-specific deletion of Hrpt2/Cdc73 results in high bone mass and increased bone turnover. Bone. 2017 May;98:68-78

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory