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Cdc73
Gene Detail
Symbol

Name
ID
Cdc73
cell division cycle 73, Paf1/RNA polymerase II complex component
MGI:2384876
Synonyms
8430414L16Rik, C130030P16Rik, Hrpt2, MGC:29274, MGC:36559
Feature Type
protein coding gene
Genetic Map
Chromosome 1
62.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:143598800-143702893 bp, - strand
From VEGA annotation of GRCm38

  104094 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11571  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDC73
Gene Tree: Cdc73

Human
homologs
CDC73, cell division cycle 73
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79577
neXtProt AC: NX_Q6P1J9

Human Synonyms: C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX

Human Chr (Location): 1q25; chr1:193121958-193254815 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CDC73

Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(30) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit embryonic lethality around hatching or implantation.
 
Interactions
Cdc73 interacts with 537 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell cycle, cellular response to lipopolysaccharide, ...
Component Cdc73/Paf1 complex, nucleus
Function protein binding, RNA polymerase II core binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (115)    Tissues (61)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 43
Western blot 38
RT-PCR 21
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cdc73 ; ZFIN cdc73    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000030974 (Evidence)
Ensembl Gene Model ENSMUSG00000026361 (Evidence)
Entrez Gene 214498 (Evidence)
DFCI TC1578406, TC1598636, TC1611257, TC1676091
DoTS DT.110915608, DT.525769, DT.55112906, DT.91336626, DT.97346215
NIA Mouse Gene Index U021852, U232812
Consensus CDS Project CCDS15341.1
International Mouse Phenotyping Consortium Status Cdc73
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030974 VEGA Gene Model | MGI Sequence Detail 104094 C57BL/6J ±  kb
transcript OTTMUST00000076702 VEGA | MGI Sequence Detail 11586 Not Applicable 
polypeptide OTTMUSP00000040421 VEGA | MGI Sequence Detail 531 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(464 from dbSNP Build 137)    SNPs within 2kb including multiple locations(466)
Protein-related
information
ResourceIDDescription
InterPro IPR007852 RNA polymerase II accessory factor, Cdc73
Protein Ontology PR:000005219 parafibromin
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:202503 Muntean AG, et al., MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction. Blood. 2013 Sep 12;122(11):1914-22
All references(43)
Other
accession IDs
MGI:1922999, MGI:2138700, MGI:2444564

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory