Cdc73
Gene Detail

Symbol Name ID

Cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component MGI:2384876

Synonyms

8430414L16Rik, C130030P16Rik, Hrpt2, MGC:29274, MGC:36559

Feature Type

protein coding gene

Genetic Map

Chromosome 1

62.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:143598797-143702893 bp, - strand From VEGA annotation of GRCm38   104097 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11571  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Human homologs

Human Homolog		CDC73, cell division cycle 73
NCBI Gene ID		79577
neXtProt AC		NX_Q6P1J9
Human Synonyms		C1orf28, HPTJT, HRPT2, HYX
Human Chr (Location)		1q25; chr1:193091088-193223945 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human CDC73

Alleles and phenotypes

All alleles(34) : Targeted(4) Gene trapped(30)
 

Mice homozygous for a null allele exhibit embryonic lethality around hatching or implantation.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	cell cycle, cellular response to lipopolysaccharide, ...
Component	Cdc73/Paf1 complex, nucleus
Function	protein binding, RNA polymerase II core binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (107)    Tissues (55)    Images (13)
Theiler Stages: 19, 20, 23, 24, 28

Assay Type	Results
Immunohistochemistry	13
RNA in situ	43
Western blot	30
RT-PCR	21

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000030974 (Evidence)
Ensembl Gene Model	ENSMUSG00000026361 (Evidence), ENSMUSG00000078284 (Evidence)
Entrez Gene	214498 (Evidence)
DFCI	TC1578406, TC1598636, TC1611257, TC1676091
DoTS	DT.110915608, DT.525769, DT.55112906, DT.91336626, DT.97346215
NIA Mouse Gene Index	U021852, U232812
Consensus CDS Project	CCDS15341.1
International Mouse Knockout Project Status	Cdc73

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030974	VEGA Gene Model | MGI Sequence Detail	104097	C57BL/6J
transcript	OTTMUST00000076702	VEGA | MGI Sequence Detail	11589	Not Applicable
polypeptide	OTTMUSP00000040421	VEGA | MGI Sequence Detail	531	Not Applicable

All sequences(48) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(316 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007852	RNA polymerase II accessory factor, Cdc73
Protein Ontology	PR:000005219	parafibromin

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:183708 Vethantham V, et al., Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation. Mol Cell Biol. 2012 Mar;32(6):1044-55
All references(42)

Other accession IDs

MGI:1922999, MGI:2138700, MGI:2444564