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Phenotypes Associated with This Genotype
Genotype
MGI:5925391
Allelic
Composition
Cdc73Gt(RRE190)Byg/Cdc73+
Genetic
Background
B6.129P2-Cdc73Gt(RRE190)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc73Gt(RRE190)Byg mutation (1 available); any Cdc73 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• decrease in survival of male mice is seen from 7 months of age

neoplasm
• 68% of mice exhibit parathyroid tumors between 9 and 18 months of age
• parathyroid tumors have higher daily proliferation rates compared to wild-type parathyroids
• however, ossifying fibromas of the jaw, and tumors of the kidneys, thyroid, pancreas or testis are not seen
• 25% of parathyroid tumors are adenomas and 75% are atypical parathyroid adenomas
• 33% of females aged over 18 months of age exhibit uterine tumors
• uterine tumors include adenofibroma and adenomyoma

craniofacial
• jaw bones show 2-fold increase in proliferation rates

endocrine/exocrine glands
• 68% of mice exhibit parathyroid tumors between 9 and 18 months of age
• parathyroid tumors have higher daily proliferation rates compared to wild-type parathyroids
• however, ossifying fibromas of the jaw, and tumors of the kidneys, thyroid, pancreas or testis are not seen
• 25% of parathyroid tumors are adenomas and 75% are atypical parathyroid adenomas
• mice over 17 months of age show features of primary hyperparathyroidism

homeostasis/metabolism
• mice with parathyroid tumors exhibit increased mean serum parathyroid hormone concentration
• mice with parathyroid tumors exhibit increased mean serum calcium concentrations
• however, levels of serum phosphate, creatinine, and albumin are normal

reproductive system
• uteri of females aged over 18 months has large cysts within the endometrium
• 33% of females aged over 18 months of age exhibit uterine tumors
• uterine tumors include adenofibroma and adenomyoma
• endometrial hyperplasia with areas of squamous metaplasia
• myometria have a 2-fold increase in proliferation rates

skeleton
• jaw bones show 2-fold increase in proliferation rates

growth/size/body
• uteri of females aged over 18 months has large cysts within the endometrium

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hyperparathyroidism DOID:13543 OMIM:145000
OMIM:145001
OMIM:610071
J:243366


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory