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Cdc73Gt(RRE190)Byg
Gene trapped Allele Detail
Summary
Symbol: Cdc73Gt(RRE190)Byg
Name: cell division cycle 73, Paf1/RNA polymerase II complex component; gene trap RRE190, BayGenomics
MGI ID: MGI:3794028
Synonyms: Hrpt2-
Gene: Cdc73  Location: Chr1:143479014-143578631 bp, - strand  Genetic Position: Chr1, 62.52 cM
Alliance: Cdc73Gt(RRE190)Byg page
Mutation
origin
Mutant Cell Line:  RRE190
Germline Transmission:  Earliest citation of germline transmission: J:135255
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT2Lxf     Vector Type: gene trap
 
Mutation detailsThe gene trap vector containing a beta-geo cassette was inserted downstream of exon 6. The resulting fusion protein lacks the 361 carboxy terminal amino acids. This is a reporter allele and a gene trapped allele. (J:135255)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Cdc73Gt(RRE190)Byg
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdc73 Mutation:  45 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:135255 Wang P, et al., Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol. 2008 May;28(9):2930-40
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory