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Phenotypes Associated with This Genotype
Genotype
MGI:5925397
Allelic
Composition
Cdc73tm1Btt/Cdc73tm1Btt
Tg(PTH-cre)4167Slib/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc73tm1Btt mutation (0 available); any Cdc73 mutation (45 available)
Tg(PTH-cre)4167Slib mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• some mice exhibit parathyroid tumors over 18 months of age
• parathyroids with tumors show glandular enlargement, nuclear pleomorphism and septation
• parathyroid tumors have higher daily proliferation rates compared to wild-type parathyroids
• 75% of parathyroid tumors sow features of APAs including increased collagen deposition in the septa, reduced nuclear expression of parfibromin and increased expression of galectin-3

homeostasis/metabolism
• mice over 20 months of age exhibit elevated mean serum calcium concentrations
• however, levels of serum albumin, creatinine, and phosphate concentrations are normal

neoplasm
• some mice exhibit parathyroid tumors over 18 months of age
• parathyroids with tumors show glandular enlargement, nuclear pleomorphism and septation
• parathyroid tumors have higher daily proliferation rates compared to wild-type parathyroids
• 75% of parathyroid tumors sow features of APAs including increased collagen deposition in the septa, reduced nuclear expression of parfibromin and increased expression of galectin-3

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hyperparathyroidism DOID:13543 OMIM:145000
OMIM:145001
OMIM:610071
J:243366


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory