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Targeted Allele Detail
Symbol: Cdc73tm1Btt
Name: cell division cycle 73, Paf1/RNA polymerase II complex component; targeted mutation 1, Bin Tean Teh
MGI ID: MGI:3794030
Synonyms: Hrpt2L
Gene: Cdc73  Location: Chr1:143479014-143578631 bp, - strand  Genetic Position: Chr1, 62.52 cM
Alliance: Cdc73tm1Btt page
Germline Transmission:  Earliest citation of germline transmission: J:135255
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2 and an additional loxP site was inserted upstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed. (J:135255)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 16 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Cdc73tm1Btt
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc73 Mutation:  45 strains or lines available
Original:  J:135255 Wang P, et al., Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol. 2008 May;28(9):2930-40
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory