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Boc
Gene Detail
 Symbol
Name
ID
Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
MGI:2151153
Feature Type protein coding gene
Genetic Map
Chromosome 16
28.81 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:44485049-44558897 bp, - strand
From VEGA annotation of GRCm38

  73849 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32819  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Boc

Human
homologs
Human Homolog BOC, BOC cell adhesion associated, oncogene regulated
NCBI Gene ID 91653
neXtProt AC  NX_Q9BWV1
Human Synonyms  CDON2
Human Chr (Location)  3q13.2; chr3:113211482-113287459 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display abnormal commissural axon projections.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Boc interacts with 201 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process axon guidance, cell adhesion, ...
Component axon, axonal growth cone, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (450)    Tissues (261)    Images (61)
Theiler Stages: 10, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 445
RT-PCR 5
cDNA source data(67)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(71) cDNA(68) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000014980 (Evidence)
Ensembl Gene ModelENSMUSG00000022687 (Evidence)
Entrez Gene117606 (Evidence)
UniGene41561
DFCITC1577330, TC1594543
DoTSDT.101386878, DT.101386880, DT.528995, DT.94238253
NIA Mouse Gene IndexU037063
PDB1X4Y, 1X4Z
Consensus CDS ProjectCCDS28186.1
International Mouse Knockout Project StatusBoc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014980 VEGA Gene Model | MGI Sequence Detail 73849 C57BL/6J ±  kb
transcript OTTMUST00000035560 VEGA | MGI Sequence Detail 4452 Not Applicable 
polypeptide OTTMUSP00000015934 VEGA | MGI Sequence Detail 1059 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(475 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000004784 brother of CDO
References (Earliest) J:72468 Kang JS, et al., BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. EMBO J. 2002 Jan 15;21(1-2):114-24
(Latest) J:198426 Sanchez-Arrones L, et al., Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina. J Neurosci. 2013 May 15;33(20):8596-607
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory