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Boc Gene Detail
Summary
  • Symbol
    Boc
  • Name
    biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151153
    NCBI Gene: 117606
  • Gene Overview
    MyGene.info: BOC
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:44485049-44558897 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      73849 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 28.81 cM, cytoband B5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BOC, BOC cell adhesion associated, oncogene regulated
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BOC, BOC cell adhesion associated, oncogene regulated
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDON2
  • Links
    NCBI Gene ID: 91653
    neXtProt AC: NX_Q9BWV1
    UniProt: Q9BWV1

  • Chr Location
    3q13.2; chr3:113211003-113287463 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32819
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BOC
  • Gene Tree
    Boc
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 5 genetic backgrounds
    33 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormal commissural axon projections.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014980 VEGA Gene Model | MGI Sequence Detail 73849 C57BL/6J ±  kb
    transcript OTTMUST00000035560 VEGA | MGI Sequence Detail 4452 Not Applicable  
    polypeptide OTTMUSP00000015934 VEGA | MGI Sequence Detail 1059 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      473 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 70
      Primer pair 2
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 29
      Diseases 1
      Gene Ontology 7
      Phenotypes 22
    • Earliest
      J:72468 Kang JS, et al., BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. EMBO J. 2002 Jan 15;21(1-2):114-24
    • Latest
      J:260449 Singh PNP, et al., Precise spatial restriction of BMP signaling in developing joints is perturbed upon loss of embryo movement. Development. 2018 Mar 12;145(5)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory