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Boc
Gene Detail
Symbol

Name
ID
Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
MGI:2151153
Feature Type
protein coding gene
Genetic Map
Chromosome 16
28.81 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:44485049-44558897 bp, - strand
From VEGA annotation of GRCm38

  73849 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32819  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BOC
Gene Tree: Boc

Human
homologs
BOC, BOC cell adhesion associated, oncogene regulated
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 91653
neXtProt AC: NX_Q9BWV1

Human Synonyms: CDON2

Human Chr (Location): 3q13.2; chr3:113211003-113287463 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display abnormal commissural axon projections.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Boc interacts with 201 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process activation of mitophagy in response to mitochondrial depolarization, axon guidance, ...
Component axon, axonal growth cone, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (450)    Tissues (261)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 445
RT-PCR 5
cDNA source data(67)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA BOC ; Xenbase boc ; ZFIN boc    NEW 
Molecular
reagents
All nucleic(71) cDNA(68) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000014980 (Evidence)
Ensembl Gene Model ENSMUSG00000022687 (Evidence)
Entrez Gene 117606 (Evidence)
UniGene 41561
DFCI TC1577330, TC1594543
DoTS DT.101386878, DT.101386880, DT.528995, DT.94238253
NIA Mouse Gene Index U037063
PDB 1X4Y, 1X4Z
Consensus CDS Project CCDS28186.1
International Mouse Phenotyping Consortium Status Boc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014980 VEGA Gene Model | MGI Sequence Detail 73849 C57BL/6J ±  kb
transcript OTTMUST00000035560 VEGA | MGI Sequence Detail 4452 Not Applicable 
polypeptide OTTMUSP00000015934 VEGA | MGI Sequence Detail 1059 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(475 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000004784 brother of CDO
References
(Earliest) J:72468 Kang JS, et al., BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. EMBO J. 2002 Jan 15;21(1-2):114-24
(Latest) J:222294 Walker KA, et al., Fgfr2 is integral for bladder mesenchyme patterning and function. Am J Physiol Renal Physiol. 2015 Apr 15;308(8):F888-98
All references(53)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory