Boc
Gene Detail

Symbol Name ID

Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein MGI:2151153

Feature Type

protein coding gene

Genetic Map

Chromosome 16

28.81 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:44485049-44558897 bp, - strand From VEGA annotation of GRCm38   73849 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32819  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Boc

Human homologs

Human Homolog		BOC, BOC cell adhesion associated, oncogene regulated
NCBI Gene ID		91653
neXtProt AC		NX_Q9BWV1
Human Synonyms		CDON2
Human Chr (Location)		3q13.2; chr3:112931375-113006306 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for a null mutation display abnormal commissural axon projections.

 
Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	axon guidance, cell adhesion, ...
Component	axon, cell surface, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (450)    Tissues (261)    Images (61)
Theiler Stages: 10, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	445
RT-PCR	5

cDNA source data(67)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(71) cDNA(68) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000014980 (Evidence)
Ensembl Gene Model	ENSMUSG00000022687 (Evidence)
Entrez Gene	117606 (Evidence)
UniGene	41561
DFCI	TC1577330, TC1594543
DoTS	DT.101386878, DT.101386880, DT.528995, DT.94238253
NIA Mouse Gene Index	U037063
PDB	1X4Y, 1X4Z
Consensus CDS Project	CCDS28186.1
International Mouse Knockout Project Status	Boc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014980	VEGA Gene Model | MGI Sequence Detail	73849	C57BL/6J
transcript	OTTMUST00000035560	VEGA | MGI Sequence Detail	4452	Not Applicable
polypeptide	OTTMUSP00000015934	VEGA | MGI Sequence Detail	1059	Not Applicable

All sequences(32) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(386 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
Protein Ontology	PR:000004784	brother of CDO

References

(Earliest) J:72468 Kang JS, et al., BOC, an Ig superfamily member, associates with CDO to positively regulate myogenic differentiation. EMBO J. 2002 Jan 15;21(1-2):114-24
(Latest) J:183457 Harwell CC, et al., Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation. Neuron. 2012 Mar 22;73(6):1116-26
All references(44)