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Sirt1 Gene Detail
Summary
  • Symbol
    Sirt1
  • Name
    sirtuin 1
  • Synonyms
    Sir2, Sir2alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135607
    NCBI Gene: 93759
  • Gene Overview
    MyGene.info: SIRT1
Location & Maps
more
  • Sequence Map
    Chr10:63319005-63381704 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62700 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.57 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SIRT1, sirtuin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIRT1, sirtuin 1
    Orthology source: HomoloGene
  • Synonyms
    SIR2, SIR2alpha, SIR2L1
  • Links
    NCBI Gene ID: 23411
    neXtProt AC: NX_Q96EB6

  • Chr Location
    10q21.3; chr10:67884662-67918390 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Sirt1 mouse models

Human Disease Mouse Models
       Diabetes Insipidus, Nephrogenic, Autosomal   OMIM: 125800 View 1 model
Fatty Liver Disease, Nonalcoholic, Susceptibility to, 1; NAFLD1   OMIM: 613282 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    151 phenotypes from 14 alleles in 15 genetic backgrounds
    18 phenotypes from multigenic genotypes
    1 images
    177 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    56
  • Chemically induced (other)
    1
  • Gene trapped
    33
  • Radiation induced
    1
  • Targeted
    19
  • Transgenic
    2
  • Genomic Mutations
    2 involving Sirt1
  • Incidental Mutations
Mice homozygous for a knock-out allele show embryonic and fetal lethality, abnormal embryogenesis, and abnormal cellular phenotypes of derived MEFs. Mice homozygous for other knock-out alleles may exhibit peri- and postnatal lethality and heart, mammary gland, eye, and reproductive system anomalies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030914 VEGA Gene Model | MGI Sequence Detail 62700 C57BL/6J ±  kb
transcript OTTMUST00000076493 VEGA | MGI Sequence Detail 4430 Not Applicable  
polypeptide OTTMUSP00000040277 VEGA | MGI Sequence Detail 737 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    136 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000014888 NAD-dependent protein deacetylase sirtuin-1
  • EC
  • InterPro Domains
    IPR029035 DHS-like NAD/FAD-binding domain
    IPR003000 Sirtuin family
    IPR026590 Sirtuin family, catalytic core domain
    IPR026591 Sirtuin family, catalytic core small domain
Molecular
Reagents
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  • All nucleic 23
    cDNA 18
    Primer pair 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143506
References
more
  • Summaries
    All 301
    Developmental Gene Expression 16
    Diseases 3
    Gene Ontology 54
    Phenotypes 177
  • Earliest
    J:65145 Imai S, et al., Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 2000 Feb 17;403(6771):795-800
  • Latest
    J:232936 Yamamoto T, et al., Cardiac Sirt1 mediates the cardioprotective effect of caloric restriction by suppressing local complement system activation after ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H1003-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory