Sirt1
Gene Detail

Symbol Name ID

Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) MGI:2135607

Synonyms

Sir2, Sir2alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 10

32.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:63319005-63381704 bp, - strand From VEGA annotation of GRCm38   62700 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56556  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: NAD-dependent deacetylase sirtuin-1, animal type
Gene Tree: Sirt1

Human homologs

Human Homolog		SIRT1, sirtuin 1
NCBI Gene ID		23411
neXtProt AC		NX_Q96EB6
Human Synonyms		SIR2L1
Human Chr (Location)		10q21.3; chr10:69644427-69678147 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(46) : Targeted(13) Gene trapped(33)
 

Mice homozygous for a knock-out allele show embryonic and fetal lethality, abnormal embryogenesis, and abnormal cellular phenotypes of derived MEFs. Mice homozygous for other knock-out alleles may exhibit peri- and postnatal lethality and heart, mammary gland, eye, and reproductive system anomalies.

 
Human Diseases Modeled Using Mouse Sirt1 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (155 annotations)

Process	angiogenesis, apoptotic process, ...
Component	chromatin, chromatin silencing complex, ...
Function	bHLH transcription factor binding, deacetylase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (143)    Tissues (91)    Images (15)
Theiler Stages: 1, 2, 3, 4, 5, 6, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	35
RNA in situ	44
Northern blot	15
Western blot	6
RT-PCR	43

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(17) Primer pair(4) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030914 (Evidence)
Ensembl Gene Model	ENSMUSG00000020063 (Evidence)
Entrez Gene	93759 (Evidence)
DFCI	TC1578732
DoTS	DT.527018, DT.97382932
NIA Mouse Gene Index	U089318
EC	3.5.1.-
Consensus CDS Project	CCDS23898.1, CCDS48585.1
International Mouse Knockout Project Status	Sirt1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030914	VEGA Gene Model | MGI Sequence Detail	62700	C57BL/6J
transcript	OTTMUST00000076493	VEGA | MGI Sequence Detail	4430	Not Applicable
polypeptide	OTTMUSP00000040277	VEGA | MGI Sequence Detail	737	Not Applicable

All sequences(58) RefSeq(5) UniProt(7)

Polymorphisms

SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003000	Sirtuin family
InterPro	IPR026590	Sirtuin family, catalytic core domain
InterPro	IPR026591	Sirtuin family, catalytic core small domain
Protein Ontology	PR:000014888	NAD-dependent deacetylase sirtuin-1

References

(Earliest) J:65145 Imai S, et al., Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 2000 Feb 17;403(6771):795-800
(Latest) J:194527 Boon RA, et al., MicroRNA-34a regulates cardiac ageing and function. Nature. 2013 Mar 7;495(7439):107-10
All references(208)

Other accession IDs

MGI:2143506