About   Help   FAQ
Sirt1 Gene Detail
Summary
  • Symbol
    Sirt1
  • Name
    sirtuin 1
  • Synonyms
    Sir2, Sir2alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135607
    NCBI Gene: 93759
  • Gene Overview
    MyGene.info: SIRT1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:63319005-63381704 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62700 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.57 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SIRT1, sirtuin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SIRT1, sirtuin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SIR2, SIR2alpha, SIR2L1
  • Links
    NCBI Gene ID: 23411
    neXtProt AC: NX_Q96EB6
    UniProt: Q96EB6

  • Chr Location
    10q21.3; chr10:67884669-67918390 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Sirt1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    168 phenotypes from 15 alleles in 16 genetic backgrounds
    38 phenotypes from multigenic genotypes
    1 images
    214 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show embryonic and fetal lethality, abnormal embryogenesis, and abnormal cellular phenotypes of derived MEFs. Mice homozygous for other knock-out alleles may exhibit peri- and postnatal lethality and heart, mammary gland, eye, and reproductive system anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030914 VEGA Gene Model | MGI Sequence Detail 62700 C57BL/6J ±  kb
    transcript OTTMUST00000076493 VEGA | MGI Sequence Detail 4430 Not Applicable  
    polypeptide OTTMUSP00000040277 VEGA | MGI Sequence Detail 737 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      136 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 19
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143506
    References
    more
    • Summaries
      All 468
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 57
      Phenotypes 214
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:262159 Jia Y, et al., SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA. Biochim Biophys Acta. 2018 Mar;1864(3):784-792

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory