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Sirt1
Gene Detail
 Symbol
Name
ID
Sirt1
sirtuin 1
MGI:2135607
Synonyms Sir2, Sir2alpha
Feature Type protein coding gene
Genetic Map
Chromosome 10
32.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:63319005-63381704 bp, - strand
From VEGA annotation of GRCm38

  62700 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: NAD-dependent deacetylase sirtuin-1, animal type
Gene Tree: Sirt1

Human
homologs
Human Homolog SIRT1, sirtuin 1
NCBI Gene ID 23411
neXtProt AC  NX_Q96EB6
Human Synonyms  SIR2L1
Human Chr (Location)  10q21.3; chr10:67884669-67918390 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(33) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show embryonic and fetal lethality, abnormal embryogenesis, and abnormal cellular phenotypes of derived MEFs. Mice homozygous for other knock-out alleles may exhibit peri- and postnatal lethality and heart, mammary gland, eye, and reproductive system anomalies.
 
Human Diseases Modeled Using Mouse Sirt1 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Sirt1 interacts with 410 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (200 annotations)
Process angiogenesis, apoptotic process, ...
Component cell, chromatin, ...
Function (3,5-dichlorophenylurea)acetate amidohydrolase activity, 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (137)    Tissues (88)    Images (15)
Theiler Stages: 1, 2, 3, 4, 6, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 35
RNA in situ 44
Northern blot 15
Western blot 6
RT-PCR 37
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(17) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030914 (Evidence)
Ensembl Gene ModelENSMUSG00000020063 (Evidence)
Entrez Gene93759 (Evidence)
DFCITC1578732
DoTSDT.527018, DT.97382932
NIA Mouse Gene IndexU089318
EC3.5.1.-
Consensus CDS ProjectCCDS23898.1, CCDS48585.1
International Mouse Knockout Project StatusSirt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030914 VEGA Gene Model | MGI Sequence Detail 62700 C57BL/6J ±  kb
transcript OTTMUST00000076493 VEGA | MGI Sequence Detail 4430 Not Applicable 
polypeptide OTTMUSP00000040277 VEGA | MGI Sequence Detail 737 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(9) UniProt(7)
Polymorphisms SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003000 Sirtuin family
InterPro IPR026590 Sirtuin family, catalytic core domain
InterPro IPR026591 Sirtuin family, catalytic core small domain
Protein Ontology PR:000014888 NAD-dependent protein deacetylase sirtuin-1
References (Earliest) J:65145 Imai S, et al., Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 2000 Feb 17;403(6771):795-800
(Latest) J:212204 Michan S, et al., Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. PLoS One. 2014;9(1):e85031
All references(247)
Disease annotation references (3)
Other
accession IDs
MGI:2143506

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory