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Sirt1
Gene Detail
Symbol

Name
ID
Sirt1
sirtuin 1
MGI:2135607
Synonyms
Sir2, Sir2alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 10
32.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:63319005-63381704 bp, - strand
From VEGA annotation of GRCm38

  62700 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SIRT1
Protein SuperFamily: NAD-dependent deacetylase sirtuin-1, animal type
Gene Tree: Sirt1

Human
homologs
SIRT1, sirtuin 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23411
neXtProt AC: NX_Q96EB6

Human Synonyms: hSIR2, SIR2, SIR2L1

Human Chr (Location): 10q21.3; chr10:67884662-67918390 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(52) : Gene trapped(33) Targeted(18) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele show embryonic and fetal lethality, abnormal embryogenesis, and abnormal cellular phenotypes of derived MEFs. Mice homozygous for other knock-out alleles may exhibit peri- and postnatal lethality and heart, mammary gland, eye, and reproductive system anomalies.
 
Human Diseases Modeled in Mice Using Sirt1 (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Sirt1 interacts with 410 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (230 annotations)
Process angiogenesis, apoptotic process, ...
Component axon, cell, ...
Function (3,5-dichlorophenylurea)acetate amidohydrolase activity, 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (137)    Tissues (88)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 35
RNA in situ 44
Northern blot 15
Western blot 6
RT-PCR 37
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sirt1 ; ZFIN sirt1    NEW 
Molecular
reagents
All nucleic(22) cDNA(17) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000030914 (Evidence)
Ensembl Gene Model ENSMUSG00000020063 (Evidence)
Entrez Gene 93759 (Evidence)
DFCI TC1578732
DoTS DT.97382932, DT.527018
NIA Mouse Gene Index U089318
EC 3.5.1.-
Consensus CDS Project CCDS23898.1, CCDS48585.1
International Mouse Phenotyping Consortium Status Sirt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030914 VEGA Gene Model | MGI Sequence Detail 62700 C57BL/6J ±  kb
transcript OTTMUST00000076493 VEGA | MGI Sequence Detail 4430 Not Applicable 
polypeptide OTTMUSP00000040277 VEGA | MGI Sequence Detail 737 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(11) UniProt(7)
Polymorphisms
SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003000 Sirtuin family
InterPro IPR026590 Sirtuin family, catalytic core domain
InterPro IPR026591 Sirtuin family, catalytic core small domain
Protein Ontology PR:000014888 NAD-dependent protein deacetylase sirtuin-1
References
(Earliest) J:65145 Imai S, et al., Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 2000 Feb 17;403(6771):795-800
(Latest) J:220559 Fei Y, et al., Sirtuin 1 Is a Negative Regulator of Parathyroid Hormone Stimulation of Matrix Metalloproteinase 13 Expression in Osteoblastic Cells: ROLE OF SIRTUIN 1 IN THE ACTION OF PTH ON OSTEOBLASTS. J Biol Chem. 2015 Mar 27;290(13):8373-82
All references(277)
Disease annotation references (3)
Other
accession IDs
MGI:2143506

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory