Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+
Tg(Agrp-cre)1Gsb/0
involves: 129 * C57BL/6J * FVB/N
|
abnormal homeostasis |
J:209418
|
|
normal
adipose tissue phenotype |
J:209418
|
|
normal
behavior/neurological phenotype |
J:209418
|
|
decreased food intake |
J:209418
|
|
decreased susceptibility to age related obesity |
J:209418
|
|
normal
growth/size/body region phenotype |
J:209418
|
|
normal
homeostasis/metabolism phenotype |
J:209418
|
|
increased body weight |
J:209418
|
|
increased food intake |
J:209418
|
Gt(ROSA)26Sortm1(Sirt1)Ktm/Gt(ROSA)26Sor+
Tg(Pomc1-cre)16Lowl/0
involves: 129 * C57BL/6J * FVB/N
|
abnormal homeostasis |
J:209418
|
|
normal
behavior/neurological phenotype |
J:209418
|
|
decreased circulating thyroxine level |
J:209418
|
|
decreased epididymal fat pad weight |
J:209418
|
|
decreased locomotor activity |
J:209418
|
|
decreased susceptibility to age related obesity |
J:209418
|
|
decreased susceptibility to induced hypothermia |
J:209418
|
|
decreased total body fat amount |
J:209418
|
|
normal
growth/size/body region phenotype |
J:209418
|
|
normal
homeostasis/metabolism phenotype |
J:209418
|
|
increased adipose tissue noradrenaline turnover |
J:209418
|
|
increased energy expenditure |
J:209418
|
|
increased oxygen consumption |
J:209418
|
Sirt1tm1.1Cxd/Sirt1+
either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)
|
exencephaly |
J:140089
|
Sirt1tm1.1Cxd/Sirt1tm1.1Cxd
either: (involves: 129S6/SvEvTac * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * C57BL/6 * FVB/N)
|
abnormal cell cycle checkpoint function |
J:140089
|
|
abnormal cell death |
J:140089
|
|
abnormal chromosome morphology |
J:140089
|
|
abnormal DNA repair |
J:140089
|
|
abnormal DNA replication |
J:140089
|
|
abnormal head morphology |
J:140089
|
|
absent hindlimb buds |
J:140089
|
|
aneuploidy |
J:140089
|
|
decreased embryo size |
J:140089
|
|
decreased survivor rate |
J:140089
|
|
embryonic lethality during organogenesis, incomplete penetrance |
J:140089
|
|
increased cellular sensitivity to gamma-irradiation |
J:140089
|
|
increased cellular sensitivity to ultraviolet irradiation |
J:140089
|
|
increased mitotic index |
J:140089
|
|
lethality throughout fetal growth and development, incomplete penetrance |
J:140089
|
Sirt1tm1.1Vlcg/Sirt1tm1.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac
|
no abnormal phenotype detected |
J:200671
|
Sirt1tm1.1Ygu/Sirt1tm1.1Ygu
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
|
abnormal branching of the mammary ductal tree |
J:121948
|
|
abnormal mammary gland growth during pregnancy |
J:121948
|
|
abnormal mammary gland morphology |
J:121948
|
|
decreased body weight |
J:121948
|
|
hypolactation |
J:121948
|
|
neonatal lethality, incomplete penetrance |
J:121948
|
|
perinatal lethality, incomplete penetrance |
J:121948
|
|
postnatal growth retardation |
J:121948
|
|
postnatal lethality |
J:121948
|
|
normal
reproductive system phenotype |
J:121948
|
Sirt1tm1.2Cxd/Sirt1tm1.2Cxd
Tg(Alb1-cre)1Dlr/?
involves: 129S6/SvEvTac * FVB/N
|
hepatic steatosis |
J:179193
|
|
increased circulating free fatty acids level |
J:179193
|
|
increased circulating triglyceride level |
J:179193
|
|
increased liver triglyceride level |
J:179193
|
Sirt1tm1b(EUCOMM)Wtsi/Sirt1+
C57BL/6N-Sirt1tm1b(EUCOMM)Wtsi/H
|
abnormal pelvic girdle bone morphology |
J:211773
|
|
abnormal scapula morphology |
J:211773
|
|
abnormal sinus arrhythmia |
J:211773
|
|
increased basophil cell number |
J:211773
|
Sirt1tm1b(EUCOMM)Wtsi/Sirt1tm1b(EUCOMM)Wtsi
C57BL/6N-Sirt1tm1b(EUCOMM)Wtsi/H
|
abnormal iris morphology |
J:211773
|
|
abnormal maxilla morphology |
J:211773
|
|
abnormal snout morphology |
J:211773
|
|
abnormal tooth morphology |
J:211773
|
|
narrow eye opening |
J:211773
|
|
preweaning lethality, incomplete penetrance |
J:211773
|
Sirt1tm1Fwa/Sirt1tm1Fwa
involves: 129/Sv * 129S6/SvEvTac
|
abnormal atrioventricular valve morphology |
J:85542
|
|
abnormal eye development |
J:85542
|
|
abnormal eye morphology |
J:85542
|
|
abnormal heart development |
J:85542
|
|
abnormal retina layer morphology |
J:85542
|
|
abnormal retina photoreceptor morphology |
J:85542
|
|
atrial septal defect |
J:85542
|
|
decreased body size |
J:85542
|
|
decreased embryo size |
J:85542
|
|
disorganized retina inner nuclear layer |
J:85542
|
|
disorganized retina outer nuclear layer |
J:85542
|
|
exencephaly |
J:85542
|
|
normal
immune system phenotype |
J:85542
|
|
increased cellular sensitivity to ionizing radiation |
J:85542
|
|
microphthalmia |
J:85542
|
|
oligozoospermia |
J:85542
|
|
perinatal lethality, incomplete penetrance |
J:85542
|
|
postnatal lethality, incomplete penetrance |
J:85542
|
|
ventricular septal defect |
J:85542
|
Sirt1tm1Mcby/Sirt1tm1Mcby
129/Sv-Sirt1tm1Mcby
|
abnormal adult Leydig cell differentiation |
J:146009
|
|
abnormal seminiferous tubule morphology |
J:146009
|
|
abnormal Sertoli cell development |
J:146009
|
|
abnormal spermatid morphology |
J:146009
|
|
abnormal spermatocyte morphology |
J:146009
|
|
arrest of male meiosis |
J:146009
|
|
arrest of spermatogenesis |
J:146009
|
|
decreased body size |
J:146009
|
|
decreased circulating follicle stimulating hormone level |
J:146009
|
|
decreased circulating luteinizing hormone level |
J:146009
|
|
decreased Leydig cell number |
J:146009
|
|
decreased testes secretion |
J:146009
|
|
increased male germ cell apoptosis |
J:146009
|
|
male infertility |
J:146009
|
|
multinucleated giant male germ cells |
J:146009
|
|
postnatal growth retardation |
J:146009
|
|
premature death |
J:146009
|
|
normal
reproductive system phenotype |
J:146009
|
|
small seminiferous tubules |
J:146009
|
Sirt1tm1Mcby/Sirt1tm1Mcby
involves: 129
|
abnormal digit development |
J:81010
|
|
decreased body weight |
J:81010
|
|
decreased CD8-positive, alpha-beta T cell number |
J:81010
|
|
decreased embryo size |
J:81010
|
|
exocrine pancreas atrophy |
J:81010
|
|
eyelids fail to open |
J:81010
|
|
heart right ventricle hypertrophy |
J:81010
|
|
interstitial pneumonia |
J:81010
|
|
lung inflammation |
J:81010
|
|
microphthalmia |
J:81010
|
|
perinatal lethality, incomplete penetrance |
J:81010
|
|
postnatal lethality, complete penetrance |
J:81010
|
|
pulmonary edema |
J:81010
|
|
short snout |
J:81010
|
Sirt1tm1Mcby/Sirt1tm1Mcby
involves: 129S1/Sv * 129X1/SvJ
|
abnormal eyelid morphology |
J:241633
|
|
abnormal lacrimal gland morphology |
J:241633
|
|
abnormal palatal rugae morphology |
J:241633
|
|
abnormal salivary gland morphology |
J:241633
|
|
decreased body size |
J:160212,
J:241633
|
|
decreased body weight |
J:160212
|
|
eyelids fail to open |
J:160212
|
|
female infertility |
J:160212,
J:241633
|
|
hyperpnea |
J:241633
|
|
increased autoantibody level |
J:241633
|
|
lethargy |
J:241633
|
|
male infertility |
J:160212,
J:241633
|
|
ocular hypotelorism |
J:241633
|
|
perinatal lethality |
J:241633
|
|
short snout |
J:241633
|
Sirt1tm1Mcby/Sirt1tm1Mcby
involves: 129S1/Sv * 129X1/SvJ * CD-1
|
abnormal cellular respiration |
J:133127
|
|
abnormal digit development |
J:81010
|
|
abnormal estrous cycle |
J:81010
|
|
abnormal glucose tolerance |
J:133127
|
|
abnormal inguinal fat pad morphology |
J:133127
|
|
abnormal nursing |
J:81010
|
|
abnormal renal glomerulus morphology |
J:160869
|
|
abnormal seminiferous tubule epithelium morphology |
J:81010
|
|
abnormal sperm flagellum morphology |
J:81010
|
|
abnormal spermatid morphology |
J:81010
|
|
absent corpus luteum |
J:81010
|
|
absent estrous cycle |
J:81010
|
|
anovulation |
J:81010
|
|
decreased body weight |
J:81010
|
|
decreased brain weight |
J:133127
|
|
decreased CD8-positive, alpha-beta T cell number |
J:81010
|
|
decreased circulating thyroxine level |
J:133127
|
|
decreased embryo size |
J:81010
|
|
decreased locomotor activity |
J:133127
|
|
decreased testis weight |
J:81010
|
|
decreased urine osmolality |
J:160869
|
|
exocrine pancreas atrophy |
J:81010
|
|
eyelids fail to open |
J:81010
|
|
globozoospermia |
J:81010
|
|
glomerulonephritis |
J:160869
|
|
heart right ventricle hypertrophy |
J:81010
|
|
immotile sperm |
J:81010
|
|
increased anti-nuclear antigen antibody level |
J:160869
|
|
increased immunoglobulin level |
J:160869
|
|
increased insulin secretion |
J:133127
|
|
increased male germ cell apoptosis |
J:81010
|
|
increased oxygen consumption |
J:133127
|
|
increased urine antidiuretic hormone level |
J:160869
|
|
interstitial pneumonia |
J:81010
|
|
lung inflammation |
J:81010
|
|
male infertility |
J:81010
|
|
microphthalmia |
J:81010
|
|
oligozoospermia |
J:81010
|
|
perinatal lethality, incomplete penetrance |
J:81010
|
|
polydipsia |
J:160869
|
|
polyphagia |
J:133127
|
|
pulmonary edema |
J:81010
|
|
reduced female fertility |
J:81010
|
|
renal glomerular immunoglobulin deposits |
J:160869
|
|
short snout |
J:81010
|
|
slow postnatal weight gain |
J:133127
|
|
small ovary |
J:81010
|
|
teratozoospermia |
J:81010
|
|
thin uterus |
J:81010
|
Sirt1tm1Ygu/Sirt1tm1Ygu
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
no abnormal phenotype detected |
J:121948
|
Sirt1tm2.1Fwa/Sirt1tm2.1Fwa
FVB.129S6-Sirt1tm2.1Fwa
|
decreased body size |
J:162852
|
|
hypoactivity in response to feed restriction |
J:162852
|
|
normal
mortality/aging |
J:162852
|
Sirt1tm2.1Fwa/Sirt1tm2.1Fwa
involves: 129/Sv * 129S6/SvEvTac
|
abnormal eye morphology |
J:85542
|
Sirt1tm2Fwa/Sirt1tm2Fwa
involves: 129/Sv * 129S6/SvEvTac
|
abnormal eye morphology |
J:85542
|
|
atrial septal defect |
J:85542
|
Sirt1tm3.1Mcby/Sirt1tm3.1Mcby
involves: 129/Sv * 129S1/Sv * 129S4/SvJae * 129X1/SvJ
|
abnormal lacrimal gland morphology |
J:241633
|
|
abnormal salivary gland morphology |
J:241633
|
|
ocular hypotelorism |
J:241633
|
|
reduced male fertility |
J:241633
|
|
short snout |
J:241633
|
Sirt1tm3Fwa/Sirt1tm3Fwa
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * C57BL/6 * SJL
|
abnormal circulating hormone level |
J:155802
|
|
abnormal pituitary gland physiology |
J:155802
|
|
decreased body length |
J:155802
|
|
decreased body weight |
J:155802
|
|
decreased circulating glucose level |
J:155802
|
|
decreased circulating growth hormone level |
J:155802
|
|
decreased circulating insulin level |
J:155802
|
|
decreased circulating insulin-like growth factor I level |
J:155802
|
|
decreased pituitary gland weight |
J:155802
|
|
hyperactivity |
J:155802
|
|
impaired glucose tolerance |
J:155802
|
|
increased circulating prolactin level |
J:155802
|
|
increased insulin sensitivity |
J:155802
|
|
small pituitary gland |
J:155802
|
Tg(Sirt1)ASrn/?
involves: C57BL/6 * CBA
|
decreased susceptibility to diet-induced hepatic steatosis |
J:137868
|
|
improved glucose tolerance |
J:137868
|
|
increased energy expenditure |
J:137868
|
|
increased food intake |
J:137868
|
|
increased susceptibility to endotoxin shock |
J:137868
|
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