Symbol
Name
ID

Sirt1
sirtuin 1
MGI:2135607

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

homeostasis/metabolism phenotype

increased adipose tissue noradrenaline turnover

abnormal DNA repair

abnormal DNA replication

increased insulin secretion

abnormal homeostasis

decreased susceptibility to induced hypothermia

decreased circulating glucose level

abnormal circulating hormone level

decreased circulating follicle stimulating hormone level

decreased circulating luteinizing hormone level

increased circulating prolactin level

decreased circulating insulin level

decreased circulating insulin-like growth factor I level

decreased circulating growth hormone level

decreased circulating thyroxine level

increased circulating free fatty acids level

increased circulating triglyceride level

increased energy expenditure

pulmonary edema

increased oxygen consumption

abnormal glucose tolerance

impaired glucose tolerance

improved glucose tolerance

increased insulin sensitivity

increased urine antidiuretic hormone level

increased liver triglyceride level

decreased urine osmolality

Availability

Mouse Genotype

Sirt1^tm1.1Cxd/Sirt1^tm1.1Cxd

Sirt1^tm1Mcby/Sirt1^tm1Mcby

Tg(Sirt1)ASrn/?

Sirt1^tm1.2Cxd/Sirt1^tm1.2Cxd
Tg(Alb1-cre)1Dlr/? (conditional)

Sirt1^tm3Fwa/Sirt1^tm3Fwa
Tg(Nes-cre)1Kln/0 (conditional)

Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}/Gt(ROSA)26Sor⁺
Tg(Pomc1-cre)16Lowl/0 (conditional)

Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}/Gt(ROSA)26Sor⁺
Tg(Agrp-cre)1Gsb/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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