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Ppfia1
Gene Detail
 Symbol
Name
ID
Ppfia1
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
MGI:1924750
Synonyms C030014K08Rik, liprin, Liprin-alpha1, Liprin-alpha1a, Liprin-alpha1b
Feature Type protein coding gene
Genetic Map
Chromosome 7
88.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:144476758-144553729 bp, - strand
From VEGA annotation of GRCm38

  76972 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20802  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ppfia1

Human
homologs
Human Homolog PPFIA1, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
NCBI Gene ID 8500
neXtProt AC  NX_Q13136
Human Synonyms  LIP1, LIP.1, LIPRIN
Human Chr (Location)  11q13.3; chr11:70270682-70384501 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ppfia1 interacts with 251 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process negative regulation of establishment of protein localization to plasma membrane, negative regulation of stress fiber assembly
Component cytoplasm, focal adhesion
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (29)    Tissues (29)    Images (8)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 29
cDNA source data(161)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(161) cDNA(161)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000043428 (Evidence)
Ensembl Gene ModelENSMUSG00000037519 (Evidence)
Entrez Gene233977 (Evidence)
UniGene490347
DFCITC1600458, TC1602053, TC1621032
DoTSDT.101722392, DT.40177260, DT.94213688, DT.94213692
NIA Mouse Gene IndexU029525, U365840, U375679
Consensus CDS ProjectCCDS52464.1, CCDS59738.1
International Mouse Knockout Project StatusPpfia1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043428 VEGA Gene Model | MGI Sequence Detail 76972 C57BL/6J ±  kb
transcript OTTMUST00000113932 VEGA | MGI Sequence Detail 4829 Not Applicable 
polypeptide OTTMUSP00000063626 VEGA | MGI Sequence Detail 1266 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(34) UniProt(6)
Polymorphisms SNPs within 2kb(378 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000013068 liprin-alpha-1
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:201692 Wentzel C, et al., mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. Neuron. 2013 Jun 19;78(6):1012-23
All references(36)
Other
accession IDs
MGI:2142372

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory