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Ssbp3 Gene Detail
Summary
  • Symbol
    Ssbp3
  • Name
    single-stranded DNA binding protein 3
  • Synonyms
    2610021L12Rik, 2610200M23Rik, 5730488C10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919725
    NCBI Gene: 72475
  • Gene Overview
    MyGene.info: SSBP3
Location & Maps
more
  • Sequence Map
    Chr4:106910701-107049694 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      138994 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 49.90 cM, cytoband C7
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SSBP3, single stranded DNA binding protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SSBP3, single stranded DNA binding protein 3
    Orthology source: HomoloGene
  • Synonyms
    CSDP, SSDP, SSDP1
  • Links
    NCBI Gene ID: 23648
    neXtProt AC: NX_Q9BWW4

  • Chr Location
    1p32.3; chr1:54225431-54413485 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 23411
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SSBP3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    60
  • Chemically induced (other)
    2
  • Gene trapped
    53
  • Radiation induced
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    4 involving Ssbp3
  • Incidental Mutations
Embryos homozygous for a gene trap mutation that deletes the proline-rich domain show a severe anterior truncation and a lethal headless phenotype (loss of fore- and midbrain). Embryos homozygous for a gene trap mutation which retains most of the proline-rich domain show normal head development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008276 VEGA Gene Model | MGI Sequence Detail 138994 C57BL/6J ±  kb
transcript OTTMUST00000018799 VEGA | MGI Sequence Detail 3195 Not Applicable  
polypeptide OTTMUSP00000008624 VEGA | MGI Sequence Detail 388 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    840 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000015650 single-stranded DNA-binding protein 3
  • InterPro Domains
    IPR006594 LIS1 homology motif
    IPR008116 Sequence-specific single-strand DNA-binding protein
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 5
Other
Accession IDs
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MGI:1917840, MGI:1919697, MGI:2140399, MGI:2140595
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:57548 Raval-Fernandes S, et al., Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus. Gene. 1999 Sep 3;237(1):201-7
  • Latest
    J:220544 Takeda S, et al., Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. J Clin Invest. 2015 Mar 2;125(3):1203-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory