Spink5
Gene Detail

Symbol Name ID

Spink5 serine peptidase inhibitor, Kazal type 5 MGI:1919682

Synonyms

2310065D10Rik, LEKT1

Feature Type

protein coding gene

Genetic Map

Chromosome 18

23.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:43963235-44022501 bp, + strand From VEGA annotation of GRCm38   59267 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Spink5

Human homologs

Human Homolog		SPINK5, serine peptidase inhibitor, Kazal type 5
NCBI Gene ID		11005
neXtProt AC		NX_Q9NQ38
Human Synonyms		LEKTI, LETKI, NETS, NS, VAKTI
Human Chr (Location)		5q32; chr5:147443535-147516925 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SPINK5

Alleles and phenotypes

All alleles(4) : Targeted(2) Chemically induced(1) Transposon induced(1)
 

Homozygous mutant mice display neonatal lethality, exfoliative erythroderma, and severe dehydration.

 
Human Diseases Modeled Using Mouse Spink5 (1)    Alleles Annotated to Human Diseases(4)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	epidermal cell differentiation, negative regulation of peptidase activity, ...
Component	cell cortex, cytoplasm, ...
Function	peptidase inhibitor activity, serine-type endopeptidase inhibitor activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (3)    Tissues (2)   
Theiler Stages: 23, 24

Assay Type	Results
RT-PCR	3

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016338 (Evidence)
Ensembl Gene Model	ENSMUSG00000055561 (Evidence)
Entrez Gene	72432 (Evidence)
UniGene	35369
DFCI	TC1581903, TC1598369
DoTS	DT.99852929
NIA Mouse Gene Index	U018682
Consensus CDS Project	CCDS37805.1
International Mouse Knockout Project Status	Spink5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016338	VEGA Gene Model | MGI Sequence Detail	59267	C57BL/6J
transcript	OTTMUST00000039263	VEGA | MGI Sequence Detail	4785	Not Applicable
polypeptide	OTTMUSP00000017545	VEGA | MGI Sequence Detail	1017	Not Applicable

All sequences(30) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(355 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002350	Kazal domain
Protein Ontology	PR:000015535	serine protease inhibitor Kazal-type 5

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:180855 Briot A, et al., Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in Netherton syndrome adult mouse model. J Invest Dermatol. 2010 Dec;130(12):2736-42
All references(36)

Other accession IDs

MGI:2147337