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Spink5
Gene Detail
Symbol

Name
ID
Spink5
serine peptidase inhibitor, Kazal type 5
MGI:1919682
Synonyms
2310065D10Rik, LEKT1
Feature Type
protein coding gene
Genetic Map
Chromosome 18
23.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:43963235-44022501 bp, + strand
From VEGA annotation of GRCm38

  59267 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4987  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Gene Tree: Spink5

Human
homologs
Human Homolog SPINK5, serine peptidase inhibitor, Kazal type 5
NCBI Gene ID 11005
neXtProt AC  NX_Q9NQ38
Human Synonyms  LEKTI, LETKI, NETS, NS, VAKTI
Human Chr (Location)  5q32; chr5:148063972-148137362 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SPINK5
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(2) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice display neonatal lethality, exfoliative erythroderma, and severe dehydration.
 
Human Diseases Modeled Using Mouse Spink5 (1)    Alleles Annotated to Human Diseases(4)   
Interactions
Spink5 interacts with 292 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (3)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(21) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016338 (Evidence)
Ensembl Gene ModelENSMUSG00000055561 (Evidence)
Entrez Gene72432 (Evidence)
UniGene35369
DFCITC1581903, TC1598369
DoTSDT.99852929
NIA Mouse Gene IndexU018682
Consensus CDS ProjectCCDS37805.1
International Mouse Knockout Project StatusSpink5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016338 VEGA Gene Model | MGI Sequence Detail 59267 C57BL/6J ±  kb
transcript OTTMUST00000039263 VEGA | MGI Sequence Detail 4785 Not Applicable 
polypeptide OTTMUSP00000017545 VEGA | MGI Sequence Detail 1017 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(374 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002350 Kazal domain
Protein Ontology PR:000015535 serine protease inhibitor Kazal-type 5
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208441 Bautista DM, et al., Why we scratch an itch: the molecules, cells and circuits of itch. Nat Neurosci. 2014 Feb;17(2):175-82
All references(37)
Disease annotation references (5)
Other
accession IDs
MGI:2147337

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory