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Spink5 Gene Detail
Summary
  • Symbol
    Spink5
  • Name
    serine peptidase inhibitor, Kazal type 5
  • Synonyms
    2310065D10Rik, LEKT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919682
    NCBI Gene: 72432
  • Gene Overview
    MyGene.info: SPINK5
Location & Maps
more
  • Sequence Map
    Chr18:43963235-44022501 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59267 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SPINK5, serine peptidase inhibitor, Kazal type 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPINK5, serine peptidase inhibitor, Kazal type 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LEKTI, LETKI, NETS, NS, VAKTI
  • Links
    NCBI Gene ID: 11005
    neXtProt AC: NX_Q9NQ38

  • Chr Location
    5q32; chr5:148025688-148137366 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Spink5 mouse models; 2 with human SPINK5 associations

Human Disease Mouse Models
       Netherton Syndrome; NETH   OMIM: 256500 View 5 models
       IgE Responsiveness, Atopic; IGER   OMIM: 147050
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (ENU)
    1
  • Targeted
    2
  • Transposon induced
    1
  • Incidental Mutations
Homozygous mutant mice display neonatal lethality, exfoliative erythroderma, and severe dehydration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016338 VEGA Gene Model | MGI Sequence Detail 59267 C57BL/6J ±  kb
transcript OTTMUST00000039263 VEGA | MGI Sequence Detail 4785 Not Applicable  
polypeptide OTTMUSP00000017545 VEGA | MGI Sequence Detail 1017 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    382 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR002350 Kazal domain
Molecular
Reagents
less
  • All nucleic 22
    cDNA 21
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147337
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Diseases 6
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:208441 Bautista DM, et al., Why we scratch an itch: the molecules, cells and circuits of itch. Nat Neurosci. 2014 Feb;17(2):175-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory