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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Spink5
serine peptidase inhibitor, Kazal type 5
MGI:1919682
61 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Spink5em1(IMPC)J/Spink5+
C57BL/6NJ-Spink5em1(IMPC)J/Mmjax 		absent vibrissae J:211773
Spink5em1(IMPC)J/Spink5em1(IMPC)J
C57BL/6NJ-Spink5em1(IMPC)J/Mmjax 		preweaning lethality, complete penetrance J:211773
Spink5m1Btlr/Spink5m1Btlr
involves: C57BL/6J 		flaky skin J:183755
increased neutrophil cell number J:183755
scaly skin J:183755
skin lesions J:183755
Spink5tm1Drh/Spink5tm1Drh
involves: 129P2/OlaHsd * C57BL/6 		abnormal corneocyte envelope morphology J:95549
abnormal epidermal layer morphology J:95549
dehydration J:95549
hyperkeratosis J:95549
impaired skin barrier function J:95549
neonatal lethality, complete penetrance J:95549
Spink5tm1Hov/Spink5tm1Hov
involves: 129P2/OlaHsd * FVB 		abnormal epidermal layer morphology J:96435
abnormal epidermis stratum corneum morphology J:96435
abnormal epidermis stratum granulosum morphology J:96435
abnormal hair follicle morphology J:96435
abnormal hair shaft morphology J:96435
abnormal vibrissa follicle morphology J:96435
abnormal vibrissa morphology J:96435
acanthosis J:96435
decreased skin tensile strength J:96435
epidermal desquamation J:96435
hyperkeratosis J:96435
impaired skin barrier function J:96435
neonatal lethality, complete penetrance J:96435
parakeratosis J:96435
reddish skin J:96435
scaly skin J:96435
skin lesions J:96435
sparse vibrissae J:96435
Spink5tm1Hov/Spink5tm2.1Hov
Tg(KRT5-cre/ERT2)2Ipc/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JRj * SJL 		alopecia J:357366
cachexia J:357366
premature death J:357366
scaly skin J:357366
skin lesions J:357366
weight loss J:357366
Spink5tm2.1Hov/Spink5tm2.1Hov
Tg(KRT5-cre/ERT2)2Ipc/0
involves: C57BL/6 * C57BL/6JRj * SJL 		abnormal dermal layer morphology J:357366
abnormal epidermis stratum corneum morphology J:357366
abnormal keratinocyte differentiation J:357366
abnormal lymph node B cell domain morphology J:357366
abnormal lymph node germinal center morphology J:357366
abnormal skin development J:357366
abnormal skin morphology J:357366
abnormal spleen marginal zone morphology J:357366
abnormal spleen morphology J:357366
abnormal thymus morphology J:357366
alopecia J:357366
arrested T cell differentiation J:357366
cachexia J:357366
decreased collagen level J:357366
decreased double-positive T cell number J:357366
decreased spleen B cell follicle number J:357366
enlarged lymph nodes J:357366
enlarged spleen J:357366
focal hair loss J:357366
hyperkeratosis J:357366
impaired skin barrier function J:357366
increased chemokine level J:357366
increased enzyme/coenzyme level J:357366
increased IgE level J:357366
increased keratinocyte proliferation J:357366
increased neutrophil cell number J:357366
increased spleen white pulp amount J:357366
loss of vibrissae J:357366
lymph node hyperplasia J:357366
myeloid hyperplasia J:357366
parakeratosis J:357366
premature death J:357366
scaly skin J:357366
skin inflammation J:357366
skin lesions J:357366
small thymus J:357366
spleen hypoplasia J:357366
thick epidermis J:357366
thymus atrophy J:357366
thymus cortex hypoplasia J:357366
thymus hypoplasia J:357366
weight loss J:357366
Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove/Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
involves: FVB/N 		abnormal epidermis stratum corneum morphology J:93050
abnormal epidermis stratum granulosum morphology J:93050
blistering J:93050
dehydration J:93050
impaired skin barrier function J:93050
normal integument phenotype J:93050
neonatal lethality, complete penetrance J:93050
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory