Spink5^tm2.1Hov
Targeted Allele Detail

Summary

• Symbol: Spink5^tm2.1Hov
• Name: serine peptidase inhibitor, Kazal type 5; targeted mutation 2.1, Alain Hovnanian
• MGI ID: MGI:7863868
• Synonyms: Spink5^fl
• Gene: Spink5 Location: Chr18:44096302-44155568 bp, + strand Genetic Position: Chr18, 23.74 cM
• Alliance: Spink5^tm2.1Hov page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:357366
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and FRT-flanked neomycin resistance gene were inserted downstream of exon 3. The neomycin resistance gene was removed via flp-mediated recombination leaving exon 3 floxed. (J:357366)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spink5 Mutation: 58 strains or lines available

References

• Original: J:357366 Petrova E, et al., Comparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways. Commun Biol. 2024 Feb 5;7(1):152
• All: 1 reference(s)