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Ncstn
Gene Detail
Symbol

Name
ID
Ncstn
nicastrin
MGI:1891700
Synonyms
9430068N19Rik, D1Dau13e, mKIAA0253, Nct, nicastrin
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:172066013-172082795 bp, - strand
From VEGA annotation of GRCm38

  16783 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41029  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NCSTN
Gene Tree: Ncstn

Human
homologs
NCSTN, nicastrin
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 23385
neXtProt AC: NX_Q92542

Human Synonyms: ATAG1874

Human Chr (Location): 1q22-q23; chr1:160343273-160358952 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NCSTN

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(15) Targeted(11)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant embryos die exhibiting morphological defects of the somites, yolk sac vasculature, neural tube, and pericardial sacs.
 
Phenotype Images(1)
Interactions
Ncstn interacts with 308 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process beta-amyloid metabolic process, epithelial cell proliferation, ...
Component endoplasmic reticulum, extracellular exosome, ...
Function endopeptidase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (33)    Tissues (19)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
RT-PCR 7
cDNA source data(153)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ncstn    NEW 
Molecular
reagents
All nucleic(168) Genomic(14) cDNA(153) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021508 (Evidence)
Ensembl Gene Model ENSMUSG00000003458 (Evidence)
Entrez Gene 59287 (Evidence)
UniGene 218203
DFCI TC1574485, TC1687370
DoTS DT.91391064, DT.110908249, DT.533743, DT.110908261
NIA Mouse Gene Index U022065
Consensus CDS Project CCDS15507.1
International Mouse Phenotyping Consortium Status Ncstn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021508 VEGA Gene Model | MGI Sequence Detail 16783 C57BL/6J ±  kb
transcript OTTMUST00000050982 VEGA | MGI Sequence Detail 2901 Not Applicable 
polypeptide OTTMUSP00000023933 VEGA | MGI Sequence Detail 708 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(5) UniProt(7)
Polymorphisms
SNPs within 2kb(176 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008710 Nicastrin
Protein Ontology PR:000011049 nicastrin
References
(Earliest) J:52853 Underhill DA, et al., Physical delineation of a 700-kb region overlapping the Looptail mutation on mouse chromosome 1. Genomics. 1999 Jan 15;55(2):185-93
(Latest) J:219929 Xia D, et al., Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer's Disease. Neuron. 2015 Mar 4;85(5):967-81
All references(75)
Other
accession IDs
MGI:1347057, MGI:1888989, MGI:1915366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory