Ncstn
Gene Detail

Symbol Name ID

Ncstn nicastrin MGI:1891700

Synonyms

9430068N19Rik, D1Dau13e, mKIAA0253, Nct, nicastrin

Feature Type

protein coding gene

Genetic Map

Chromosome 1

79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr1:172066013-172082795 bp, - strand From VEGA annotation of GRCm38   16783 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee    (Mammalian Orthology)
Comparative Map (Mouse/Human Ncstn ± 2 cM)

Gene Tree: Ncstn

Human ortholog

NCSTN nicastrin NCBI Gene ID 23385
Human Synonyms: APH2
Human Chr1:160313063-160328742 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human NCSTN (1)

Alleles and phenotypes

All alleles(26) : Targeted(11) Gene trapped(15)
 

Homozygous mutant embryos die exhibiting morphological defects of the somites, yolk sac vasculature, neural tube, and pericardial sacs.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	beta-amyloid metabolic process, epithelial cell proliferation, ...
Component	endoplasmic reticulum, Golgi apparatus, ...
Function	endopeptidase activity, peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (33)    Tissues (19)    Images (2)
Theiler Stages: 13, 15, 17, 23, 28

Assay Type	Results
RNA in situ	26
RT-PCR	7

cDNA source data(153)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(168) Genomic(14) cDNA(153) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021508 (Evidence)
Ensembl Gene Model	ENSMUSG00000003458 (Evidence)
Entrez Gene	59287 (Evidence)
UniGene	218203
DFCI	TC1574485, TC1687370
DoTS	DT.110908249, DT.110908261, DT.533743, DT.91391064
NIA Mouse Gene Index	U022065
Consensus CDS Project	CCDS15507.1
International Mouse Knockout Project Status	Ncstn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021508	VEGA Gene Model | MGI Sequence Detail	16783	C57BL/6J
transcript	OTTMUST00000050982	VEGA | MGI Sequence Detail	2901	Not Applicable
polypeptide	OTTMUSP00000023933	VEGA | MGI Sequence Detail	708	Not Applicable

All sequences(52) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(120 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008710	Nicastrin
Protein Ontology	PR:000011049	nicastrin

References

(Earliest) J:52853 Underhill DA, et al., Physical delineation of a 700-kb region overlapping the Looptail mutation on mouse chromosome 1. Genomics. 1999 Jan 15;55(2):185-93
(Latest) J:185137 Billiard F, et al., Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice. J Exp Med. 2012 May 7;209(5):1011-28
All references(70)

Other accession IDs

MGI:1347057, MGI:1888989, MGI:1915366