About   Help   FAQ
Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1.1(rtTA2S*M2)Whsu
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Wei Hsu
MGI ID: MGI:3584145
Synonyms: R26rtTA
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1.1(rtTA2S*M2)Whsu page
Germline Transmission:  Earliest citation of germline transmission: J:99718
Parent Cell Line:  CSL3 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Transactivator)
Mutation:    Insertion
Mutation detailsA synthetic, modified version of the rtTA gene preceded by a loxP flanked STOP sequence was inserted into the Gt(ROSA)26Sor locus. Carriers were bred with mice transgenic for cre recombinase under the control of beta actin, excising the STOP sequence and leaving rtTA under the endogenous Gt(ROSA)26Sor promoter. This version of rtTA contains 5 amino acid changes in the TetR moiety (S12G, E19G, A56P, D148E, and H179R) and a synthetic optimized transactivating domain. This rtTA has reduced basal activity and enhanced doxycycline sensitivity compared to wild-type rtTA. (J:99718)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  811 strains or lines available
Original:  J:99718 Yu HM, et al., Development of a unique system for spatiotemporal and lineage-specific gene expression in mice. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8615-20
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory