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Park2 Gene Detail
Summary
  • Symbol
    Park2
  • Name
    Parkinson disease (autosomal recessive, juvenile) 2, parkin
  • Synonyms
    PRKN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355296
    NCBI Gene: 50873
  • Gene Overview
    MyGene.info: PARK2
Location & Maps
more
  • Sequence Map
    Chr17:10840384-12063361 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1222978 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 7.80 cM, cytoband A3.2-A3.3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PARK2, parkin RBR E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PARK2, parkin RBR E3 ubiquitin protein ligase
    Orthology source: HomoloGene
  • Synonyms
    AR-JP, LPRS2, PDJ, PRKN
  • Links
    NCBI Gene ID: 5071
    neXtProt AC: NX_O60260

  • Chr Location
    6q25.2-q27; chr6:161347417-162727802 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Park2 mouse models; 4 with human PARK2 associations

Human Disease Mouse Models
       Parkinson Disease 2, Autosomal Recessive Juvenile; PARK2   OMIM: 600116 View 10 models
       Leprosy, Susceptibility to, 2; LPRS2   OMIM: 607572
Lung Cancer   OMIM: 211980
Ovarian Cancer   OMIM: 167000
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    14 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 7 alleles in 10 genetic backgrounds
    24 phenotypes from multigenic genotypes
    1 images
    166 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Gene trapped
    9
  • Radiation induced
    5
  • Spontaneous
    2
  • Targeted
    8
  • Transgenic
    3
  • Genomic Mutations
    6 involving Park2
  • Incidental Mutations
Dopamine and glutatamate transmission are impaired in some targeted null mice, resulting in decreased exploratory behavior. These mice show decreased body weight and temperature. Park2 is inactivated as part of a large deletion in the quaking mouse, a dysmyelinating mutant with a pronounced tremor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046340 VEGA Gene Model | MGI Sequence Detail 1222978 C57BL/6J ±  kb
transcript OTTMUST00000120776 VEGA | MGI Sequence Detail 3202 Not Applicable  
polypeptide OTTMUSP00000066774 VEGA | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    9160 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 5
    cDNA 9
    Primer pair 3

    Microarray probesets 5
References
more
  • Summaries
    All 142
    Developmental Gene Expression 6
    Diseases 14
    Gene Ontology 30
    Phenotypes 166
  • Earliest
    J:61607 Kitada T, et al., Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism [see comments]. Nature. 1998 Apr 9;392(6676):605-8
  • Latest
    J:229454 Gong G, et al., Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015 Dec 4;350(6265):aad2459

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory