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Park2
Gene Detail
Symbol

Name
ID
Park2
Parkinson disease (autosomal recessive, juvenile) 2, parkin
MGI:1355296
Synonyms
PRKN
Feature Type
protein coding gene
Genetic Map
Chromosome 17
7.80 cM, cytoband A3.2-A3.3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:10840384-12063361 bp, + strand
From VEGA annotation of GRCm38

  1222978 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3355  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: parkin

Human
homologs
Human Homolog PARK2, parkin RBR E3 ubiquitin protein ligase
NCBI Gene ID 5071
neXtProt AC  NX_O60260
Human Synonyms  AR-JP, LPRS2, PDJ, PRKN
Human Chr (Location)  6q25.2-q27; chr6:161347558-162727802 (-)  GRCh38
Disease Associations  (4) Diseases Associated with Human PARK2
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(9) Spontaneous(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Dopamine and glutatamate transmission are impaired in some targeted null mice, resulting in decreased exploratory behavior. These mice show decreased body weight and temperature. Park2 is inactivated as part of a large deletion in the quaking mouse, a dysmyelinating mutant with a pronounced tremor.
 
Human Diseases Modeled Using Mouse Park2 (1)    Alleles Annotated to Human Diseases(5)    Phenotype Images(1)
Interactions
Park2 interacts with 143 markers (Mir7-1, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (125 annotations)
Process adult locomotory behavior, aggresome assembly, ...
Component aggresome, cell junction, ...
Function actin binding, chaperone binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (193)    Tissues (123)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 193
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(5) cDNA(9) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000046340 (Evidence)
Ensembl Gene ModelENSMUSG00000095795 (Evidence), ENSMUSG00000023826 (Evidence), ENSMUSG00000073465 (Evidence)
Entrez Gene50873 (Evidence)
UniGene311110
DFCITC1589817, TC1589316
DoTSDT.101275377, DT.87028441, DT.101297453, DT.97404300, DT.94169675
NIA Mouse Gene IndexU017491
EC6.3.2.-, 6.3.2.19
PDB3B1L, 2ZEQ, 1MG8
International Mouse Knockout Project StatusPark2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046340 VEGA Gene Model | MGI Sequence Detail 1222978 C57BL/6J ±  kb
transcript OTTMUST00000120776 VEGA | MGI Sequence Detail 3202 Not Applicable 
polypeptide OTTMUSP00000066774 VEGA | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(16) UniProt(16)
Polymorphisms
SNPs within 2kb(9304 from dbSNP Build 137)    SNPs within 2kb including multiple locations(9316)
Protein-related
information
ResourceIDDescription
InterPro IPR003977 Parkin
InterPro IPR000626 Ubiquitin
InterPro IPR002867 Zinc finger, C6HC-type
Protein Ontology PR:000012285 E3 ubiquitin-protein ligase parkin
References
(Earliest) J:61607 Kitada T, et al., Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism [see comments]. Nature. 1998 Apr 9;392(6676):605-8
(Latest) J:214311 Wenqiang C, et al., Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice. Hum Mol Genet. 2014 Sep 15;23(18):4960-9
All references(122)
Disease annotation references (8)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory