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Park2
Gene Detail
 Symbol
Name
ID
Park2
Parkinson disease (autosomal recessive, juvenile) 2, parkin
MGI:1355296
Synonyms PRKN
Feature Type protein coding gene
Genetic Map
Chromosome 17
7.80 cM, cytoband A3.2-A3.3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:10840384-12063361 bp, + strand
From NCBI annotation of GRCm38

  1222978 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3355  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: parkin

Human
homologs
Human Homolog PARK2, parkin RBR E3 ubiquitin protein ligase
NCBI Gene ID 5071
neXtProt AC  NX_O60260
Human Synonyms  AR-JP, LPRS2, PDJ, PRKN
Human Chr (Location)  6q25.2-q27; chr6:161347558-162727802 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human PARK2
Alleles
and
phenotypes
All alleles(18) : Targeted(8) Gene trapped(9) Spontaneous(1)
 
Dopamine and glutatamate transmission are impaired in some targeted null mice, resulting in decreased exploratory behavior. These mice show decreased body weight and temperature. Park2 is inactivated as part of a large deletion in the quaking mouse, a dysmyelinating mutant with a pronounced tremor.
 
Human Diseases Modeled Using Mouse Park2 (1)    Alleles Annotated to Human Diseases(5)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (85 annotations)
Process adult locomotory behavior, aggresome assembly, ...
Component aggresome, cell junction, ...
Function chaperone binding, identical protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (193)    Tissues (123)    Images (19)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 193
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) Genomic(5) cDNA(9) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000095795 (Evidence), ENSMUSG00000073465 (Evidence), ENSMUSG00000023826 (Evidence)
Entrez Gene50873 (Evidence)
UniGene311110
DFCITC1589316, TC1589817
DoTSDT.101275377, DT.101297453, DT.87028441, DT.94169675, DT.97404300
NIA Mouse Gene IndexU017491
EC6.3.2.-, 6.3.2.19
PDB2ZEQ, 3B1L, 1MG8
International Mouse Knockout Project StatusPark2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 50873 NCBI Gene Model | MGI Sequence Detail 1222978 C57BL/6J ±  kb
transcript NM_016694 RefSeq | MGI Sequence Detail 3202 C57BL/6 
polypeptide Q9WVS6 UniProt | EBI | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(16) UniProt(9)
Polymorphisms SNPs within 2kb(9304 from dbSNP Build 137)    SNPs within 2kb including multiple locations(9316)
Protein-related
information
ResourceIDDescription
InterPro IPR003977 Parkin
InterPro IPR015496 Ubiquilin
InterPro IPR000626 Ubiquitin
InterPro IPR002867 Zinc finger, C6HC-type
Protein Ontology PR:000012285 E3 ubiquitin-protein ligase parkin
Graphical View of Protein Domain Structure
References (Earliest) J:61607 Kitada T, et al., Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism [see comments]. Nature. 1998 Apr 9;392(6676):605-8
(Latest) J:206823 Hoshino A, et al., Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic beta-cell function in diabetes. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3116-21
All references(116)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory