Dopamine and glutatamate transmission are impaired in some targeted null mice, resulting in decreased exploratory behavior. These mice show decreased body weight and temperature. Park2 is inactivated as part of a large deletion in the quaking mouse, a dysmyelinating mutant with a pronounced tremor.
|Process||activation of mitophagy in response to mitochondrial depolarization, adult locomotory behavior, ...|
|Component||aggresome, cell junction, ...|
|Function||actin binding, chaperone binding, ...|
|VEGA Gene Model||OTTMUSG00000046340 (Evidence)|
|Ensembl Gene Model||ENSMUSG00000023826 (Evidence)|
|Entrez Gene||50873 (Evidence)|
|DoTS||DT.101275377, DT.97404300, DT.94169675, DT.101297453, DT.87028441|
|NIA Mouse Gene Index||U017491|
|PDB||3B1L, 2ZEQ, 1MG8|
|International Mouse Phenotyping Consortium Status||Park2|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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