Park2
Gene Detail

Symbol Name ID

Park2 Parkinson disease (autosomal recessive, juvenile) 2, parkin MGI:1355296

Synonyms

PRKN

Feature Type

protein coding gene

Genetic Map

Chromosome 17

7.80 cM, cytoband A3.2-A3.3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr17:10840384-12063361 bp, + strand From NCBI annotation of GRCm38   1222978 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3355  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: parkin

Human homologs

Human Homolog		PARK2, parkinson protein 2, E3 ubiquitin protein ligase (parkin)
NCBI Gene ID		5071
neXtProt AC		NX_O60260
Human Synonyms		AR-JP, LPRS2, PDJ, PRKN
Human Chr (Location)		6q25.2-q27; chr6:161768590-163148834 (-)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human PARK2

Alleles and phenotypes

All alleles(18) : Targeted(8) Gene trapped(9) Spontaneous(1)
 

Dopamine and glutatamate transmission are impaired in some targeted null mice, resulting in decreased exploratory behavior. These mice show decreased body weight and temperature. Park2 is inactivated as part of a large deletion in the quaking mouse, a dysmyelinating mutant with a pronounced tremor.

 
Human Diseases Modeled Using Mouse Park2 (1)    Alleles Annotated to Human Diseases(5)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (75 annotations)

Process	adult locomotory behavior, aggresome assembly, ...
Component	aggresome, cell junction, ...
Function	acid-amino acid ligase activity, chaperone binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (193)    Tissues (123)    Images (19)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	193

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) Genomic(5) cDNA(9) Primer pair(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000073465 (Evidence), ENSMUSG00000023826 (Evidence), ENSMUSG00000095795 (Evidence)
Entrez Gene	50873 (Evidence)
UniGene	311110
DFCI	TC1589316, TC1589817
DoTS	DT.101275377, DT.101297453, DT.87028441, DT.94169675, DT.97404300
NIA Mouse Gene Index	U017491
EC	6.3.2.-, 6.3.2.19
PDB	2ZEQ, 3B1L, 1MG8
International Mouse Knockout Project Status	Park2

Sequences

Length	Strain/Species
genomic	50873	NCBI Gene Model | MGI Sequence Detail	1222978	C57BL/6J
transcript	NM_016694	RefSeq | MGI Sequence Detail	3202	C57BL/6
polypeptide	Q9WVS6	UniProt | EBI | MGI Sequence Detail	464	Not Applicable

All sequences(48) RefSeq(2) UniProt(9)

Polymorphisms

SNPs(6373 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003977	Parkin
InterPro	IPR000626	Ubiquitin
InterPro	IPR019955	Ubiquitin supergroup
InterPro	IPR002867	Zinc finger, C6HC-type
Protein Ontology	PR:000012285	E3 ubiquitin-protein ligase parkin

Graphical View of Protein Domain Structure

References

(Earliest) J:61607 Kitada T, et al., Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism [see comments]. Nature. 1998 Apr 9;392(6676):605-8
(Latest) J:192478 Algarzae N, et al., Parkin prevents cortical atrophy and Abeta-induced alterations of brain metabolism: (1)(3)C NMR and magnetic resonance imaging studies in AD models. Neuroscience. 2012 Dec 6;225:22-34
All references(103)