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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prkn
parkin RBR E3 ubiquitin protein ligase
MGI:1355296
18 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gpx1tm1Ysh/Gpx1tm1Ysh
Prkntm1Shn/Prkntm1Shn
Park7tm1Shn/Park7tm1Shn
B6.Cg-Park7tm1Shn Gpx1tm1Ysh Prkntm1Shn 		impaired coordination J:202221
increased dopamine level J:202221
increased serotonin level J:202221
Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+
Prkntm1Roo/Prkntm1Roo
Slc6a3tm1(cre)Lrsn/Slc6a3+
Tfamtm1Lrsn/Tfamtm1Lrsn
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal axonal transport J:176022
abnormal neuron morphology J:176022
loss of dopaminergic neurons J:176022
Prkntm1Ccs/Prkntm1Ccs
Tg(CAG-SNCA*)1.1Ccs/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cellular respiration J:127707
abnormal mitochondrial ATP synthesis coupled electron transport J:127707
abnormal mitochondrial morphology J:127707
abnormal neuron morphology J:127707
brain vacuoles J:127707
normal nervous system phenotype J:127707
Prkntm1Ccs/Prkntm1Ccs
Tg(Th-SNCA*)1.2Ccs/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cellular respiration J:127707
abnormal mitochondrial ATP synthesis coupled electron transport J:127707
abnormal mitochondrial morphology J:127707
abnormal neuron morphology J:127707
brain vacuoles J:127707
normal nervous system phenotype J:127707
Prkntm1Shn/Prkntm1Shn
Park7tm1Shn/Park7tm1Shn
B6.Cg-Park7tm1Shn Prkntm1Shn 		impaired coordination J:202221
increased serotonin level J:202221
Prkntm1Shn/Prkntm1Shn
Slc6a3tm4.1(tTA)Xz/?
Tg(tetO-SNCA*A53T)E2Cai/?
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 		abnormal mitochondrial morphology J:218892
neuronal cytoplasmic inclusions J:218892
Prkntm1Ykt/Prkntm1Ykt
Tg(PDGFB-GPR37)20Ryot/0
involves: 129P2/OlaHsd * C57BL/6 		normal behavior/neurological phenotype J:140326
neuron degeneration J:140326
Prkntm1Ykt/Prkntm1Ykt
Tg(PDGFB-GPR37)20Ryot/Tg(PDGFB-GPR37)20Ryot
involves: 129P2/OlaHsd * C57BL/6 		normal behavior/neurological phenotype J:140326
neuron degeneration J:140326
Prkntm1Ykt/Prkntm1Ykt
Tg(Prp-GPR37)1Ryot/0
involves: 129P2/OlaHsd * C3H * C57BL/6 		abnormal redox activity J:140326
normal behavior/neurological phenotype J:140326
decreased dopamine level J:140326
decreased dopaminergic neuron number J:140326
increased dopamine level J:140326
neuron degeneration J:140326
oxidative stress J:140326
Prkntm1Ykt/Prkntm1Ykt
Tg(Prp-GPR37)1Ryot/Tg(Prp-GPR37)1Ryot
involves: 129P2/OlaHsd * C3H * C57BL/6 		abnormal redox activity J:140326
normal behavior/neurological phenotype J:140326
decreased dopamine level J:140326
decreased dopaminergic neuron number J:140326
increased dopamine level J:140326
neuron degeneration J:140326
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory