Bcl2l13^tm1.2Otsu
Targeted Allele Detail

Summary

• Symbol: Bcl2l13^tm1.2Otsu
• Name: BCL2 like 13; targeted mutation 1.2, Kinya Otsu
• MGI ID: MGI:8242671
• Gene: Bcl2l13 Location: Chr6:120813173-120869803 bp, + strand Genetic Position: Chr6, 57.01 cM
• Alliance: Bcl2l13^tm1.2Otsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:360813
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked PGK-neomycin selection cassette in opposite orientation and second loxP site were inserted downstream of exon 4. The neomycin selection cassette was removed via flp-mediated recombination. Exons 3-4 were deleted via cre-mediated recombination in the germline. (J:360813)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l13 Mutation: 37 strains or lines available

References

• Original: J:360813 Murakawa T, et al., AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection. Cell Rep. 2024 Dec 24;43(12):115001
• All: 1 reference(s)