Analysis Tools
homeostasis/metabolism
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• mice subjected to mild pressure overload via transverse aortic constriction (TAC) exhibit cardiac dysfunction with decreased hypertrophic responses
• cardiac function decreases in TAC-operated mice over time
• apoptosis and necrosis in TAC-operated mice are not different from wild-type levels
• however, mice show normal cardiac structure and function under basal conditions
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• cardiomyocytes from TAC-operated hearts show reduced ATP production
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• pressure overload-induced mitophagy is attenuated in cardiomyocytes
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cardiovascular system
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• cardiomyocyte cross-sectional area is smaller in the TAC-operated mice compared to TAC-operated wild-type mice
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• the population of mitochondria with shorter long diameters or smaller areas after TAC is decreased indicating that mice have elongated mitochondria after TAC compared to controls
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• TAC-operated mice show decreased left ventricle fractional shortening
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• mice subjected to mild pressure overload via transverse aortic constriction (TAC) exhibit an increase in end-systolic left ventricular (LV) internal dimension (LVID) and a decrease in LV fractional shortening (systolic function), and reduced thickness of the end-diastolic interventricular septum wall (IVSd) and LV posterior wall (LVPWd) four weeks after surgery
• 5 days after operation, TAC-operated hearts show left ventricular systolic dysfunction compared to wild-type hearts but the IVsd, LVPWD, and LV weight-to-tibia length ratios, as well as cardiomyocyte cross-sectional area are increased similarly as in wild-type mice
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• pressure overload-induced increase in oxygen consumption rate in cardiomyocyte mitochondria, mitochondrial fission, and mitophagy are attenuated
• cardiomyocytes from TAC-operated hearts show reduced ATP production and increased mtDNA damage, suggesting that damaged mitochondria escape from mitophagic degradation and produce more ROS and less ATP and accumulate in TAC-operated hearts
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• mice subjected to mild pressure overload via transverse aortic constriction (TAC) exhibit cardiac dysfunction with decreased hypertrophic responses
• cardiac function decreases in TAC-operated mice over time
• apoptosis and necrosis in TAC-operated mice are not different from wild-type levels
• however, mice show normal cardiac structure and function under basal conditions
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cellular
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• the population of mitochondria with shorter long diameters or smaller areas after TAC is decreased indicating that mice have elongated mitochondria after TAC compared to controls
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• cardiomyocytes from TAC-operated hearts show reduced ATP production
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• pressure overload-induced mitophagy is attenuated in cardiomyocytes
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• pressure overload-induced mitochondrial fission is attenuated in cardiomyocytes
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• pressure overload-induced mitochondrial fission is attenuated in cardiomyocytes
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• cardiomyocytes from TAC-operated hearts show increased mitochondrial reactive oxygen species production
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muscle
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• cardiomyocyte cross-sectional area is smaller in the TAC-operated mice compared to TAC-operated wild-type mice
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• the population of mitochondria with shorter long diameters or smaller areas after TAC is decreased indicating that mice have elongated mitochondria after TAC compared to controls
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• TAC-operated mice show decreased left ventricle fractional shortening
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