Gt(ROSA)26Sor^tm1Lrsn
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1Lrsn
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Nils-Goran Larsson
• MGI ID: MGI:5292496
• Synonyms: Gt(ROSA26)Sor^{Stop-mito-YFP}, ROSA26^{lox-Stop-lox-mito-YFP}, ROSA26^SmY
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176022
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A construct containing a floxed neo stop cassette and a mitochondrial targeted YFP was inserted into the locus. (J:176022)

Design of lox-Stop-lox-mito-YFP and targeting to the ROSA26 locus to generate the Gt(ROSA)26Sor^tm1Lrsn and Gt(ROSA)26Sor^tm1.1Lrsn alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:176022 Sterky FH, et al., Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12937-42
• All: 14 reference(s)