Hs6st1
Gene Detail

Symbol Name ID

Hs6st1 heparan sulfate 6-O-sulfotransferase 1 MGI:1354958

Synonyms

6OST1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

15.15 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:36068400-36106446 bp, + strand From VEGA annotation of GRCm38   38047 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:75051  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Gene Tree: Hs6st1

Human homologs

Human Homolog		HS6ST1, heparan sulfate 6-O-sulfotransferase 1
NCBI Gene ID		9394
neXtProt AC		NX_O60243
Human Synonyms		HH15, HS6ST
Human Chr (Location)		2q21; chr2:129023054-129076171 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HS6ST1

Alleles and phenotypes

All alleles(13) : Targeted(4) Gene trapped(9)
 

Mice homozygous for a null allele show prenatal loss, stunted growth, dilated alveoli and lower postweaning survival. Homozygotes for another null allele show additional defects in placenta, eye, phalanx and tarsus morphology. Homozygotes for a gene trap allele show altered retinal axon guidance.

 
Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	angiogenesis, heparan sulfate proteoglycan biosynthetic process, ...
Component	integral to membrane, membrane
Function	sulfotransferase activity, transferase activity

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (587)    Tissues (209)    Images (84)
Theiler Stages: 13, 14, 15, 16, 17, 18, 19, 20, 22, 23, 24, 28

Assay Type	Results
RNA in situ	558
RT-PCR	29

cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(101) cDNA(97) Primer pair(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000029555 (Evidence)
Ensembl Gene Model	ENSMUSG00000045216 (Evidence)
Entrez Gene	50785 (Evidence)
UniGene	213566
DFCI	TC1576019
DoTS	DT.101155750, DT.101203936, DT.492738, DT.97413629
NIA Mouse Gene Index	U000154
EC	2.8.2.-
Consensus CDS Project	CCDS48237.1
International Mouse Knockout Project Status	Hs6st1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029555	VEGA Gene Model | MGI Sequence Detail	38047	C57BL/6J
transcript	OTTMUST00000073283	VEGA | MGI Sequence Detail	3719	Not Applicable
polypeptide	OTTMUSP00000037912	VEGA | MGI Sequence Detail	411	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(301 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010635	Heparan sulphate 6-sulfotransferase
InterPro	IPR005331	Sulfotransferase
Protein Ontology	PR:000008765	heparan-sulfate 6-O-sulfotransferase 1

References

(Earliest) J:60682 Habuchi H, et al., The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. J Biol Chem. 2000 Jan 28;275(4):2859-68
(Latest) J:191132 Buresh-Stiemke RA, et al., Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development. Dev Dyn. 2012 Dec;241(12):2005-13
All references(50)