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Hs6st1 Gene Detail
Summary
  • Symbol
    Hs6st1
  • Name
    heparan sulfate 6-O-sulfotransferase 1
  • Synonyms
    6OST1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354958
    NCBI Gene: 50785
Location & Maps
more
  • Sequence Map
    Chr1:36068400-36106446 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38047 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 15.15 cM, cytoband B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HS6ST1, heparan sulfate 6-O-sulfotransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HS6ST1, heparan sulfate 6-O-sulfotransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HH15, HS6ST
  • Links
    NCBI Gene ID: 9394
    neXtProt AC: NX_O60243

  • Chr Location
    2q21; chr2:128265480-128318597 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HS6ST1 associations

Human Disease Mouse Models
       Hypogonadotropic Hypogonadism 15 with or without Anosmia; HH15   OMIM: 614880
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    9
  • Targeted
    4
  • Genomic Mutations
    1 involving Hs6st1
  • Incidental Mutations
Mice homozygous for a null allele show prenatal loss, stunted growth, dilated alveoli and lower postweaning survival. Homozygotes for another null allele show additional defects in placenta, eye, phalanx and tarsus morphology. Homozygotes for a gene trapallele show altered retinal axon guidance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029555 VEGA Gene Model | MGI Sequence Detail 38047 C57BL/6J ±  kb
transcript OTTMUST00000073283 VEGA | MGI Sequence Detail 3719 Not Applicable  
polypeptide OTTMUSP00000037912 VEGA | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    431 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008765 heparan-sulfate 6-O-sulfotransferase 1
  • EC
  • InterPro Domains
    IPR010635 Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR005331 Sulfotransferase
Molecular
Reagents
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  • All nucleic 104
    cDNA 99
    Primer pair 5

    Microarray probesets 3
References
more
  • Summaries
    All 52
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 21
  • Earliest
    J:60682 Habuchi H, et al., The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. J Biol Chem. 2000 Jan 28;275(4):2859-68
  • Latest
    J:214343 Cai Z, et al., Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis. Dev Dyn. 2014 Oct;243(10):1310-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory