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Hs6st1
Gene Detail
Symbol

Name
ID
Hs6st1
heparan sulfate 6-O-sulfotransferase 1
MGI:1354958
Synonyms
6OST1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
15.15 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:36068400-36106446 bp, + strand
From VEGA annotation of GRCm38

  38047 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75051  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Hs6st1

Human
homologs
Human Homolog HS6ST1, heparan sulfate 6-O-sulfotransferase 1
NCBI Gene ID 9394
neXtProt AC  NX_O60243
Human Synonyms  HH15, HS6ST
Human Chr (Location)  2q21; chr2:128265480-128318597 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HS6ST1
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(9) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show prenatal loss, stunted growth, dilated alveoli and lower postweaning survival. Homozygotes for another null allele show additional defects in placenta, eye, phalanx and tarsus morphology. Homozygotes for a gene trap allele show altered retinal axon guidance.
 
Phenotype Images(5)
Interactions
Hs6st1 interacts with 258 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (590)    Tissues (214)    Images (84)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 561
RT-PCR 29
cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(104) cDNA(99) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029555 (Evidence)
Ensembl Gene ModelENSMUSG00000045216 (Evidence)
Entrez Gene50785 (Evidence)
UniGene213566
DFCITC1576019
DoTSDT.101155750, DT.101203936, DT.492738, DT.97413629
NIA Mouse Gene IndexU000154
EC2.8.2.-
Consensus CDS ProjectCCDS48237.1
International Mouse Knockout Project StatusHs6st1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029555 VEGA Gene Model | MGI Sequence Detail 38047 C57BL/6J ±  kb
transcript OTTMUST00000073283 VEGA | MGI Sequence Detail 3719 Not Applicable 
polypeptide OTTMUSP00000037912 VEGA | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(432 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010635 Heparan sulphate 6-sulfotransferase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR005331 Sulfotransferase
Protein Ontology PR:000008765 heparan-sulfate 6-O-sulfotransferase 1
References
(Earliest) J:60682 Habuchi H, et al., The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. J Biol Chem. 2000 Jan 28;275(4):2859-68
(Latest) J:206944 Clegg JM, et al., Heparan sulfotransferases Hs6st1 and Hs2st Keep Erk in check for mouse corpus callosum development. J Neurosci. 2014 Feb 5;34(6):2389-401
All references(54)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory