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Hsd17b6
Gene Detail
Symbol

Name
ID
Hsd17b6
hydroxysteroid (17-beta) dehydrogenase 6
MGI:1351670
Synonyms
17betaHSD9, Hsd17b9, Rdh8
Feature Type
protein coding gene
Genetic Map
Chromosome 10
76.39 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:127990941-128000678 bp, - strand
From Ensembl annotation of GRCm38

  9738 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20811  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: HSD17B6
Protein SuperFamily: retinol dehydrogenase
Gene Tree: Hsd17b6

Human
homologs
HSD17B6, hydroxysteroid (17-beta) dehydrogenase 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8630
neXtProt AC: NX_O14756

Human Synonyms: HSE, RODH, SDR9C6

Human Chr (Location): 12q13; chr12:56752449-56787790 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Hsd17b6 interacts with 47 markers (Mir1a-1, Mir1a-2, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process lipid metabolic process, metabolic process, ...
Component endoplasmic reticulum, endosome, ...
Function estradiol 17-beta-dehydrogenase activity, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hsd17b6    NEW 
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000025396 (Evidence)
Entrez Gene 27400 (Evidence)
UniGene 26719
DFCI TC1585214
DoTS DT.487876, DT.94353094
NIA Mouse Gene Index U032345
EC 1.1.1.105, 1.1.1.239, 1.1.1.62
Consensus CDS Project CCDS24257.1
International Mouse Phenotyping Consortium Status Hsd17b6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025396 Ensembl Gene Model | MGI Sequence Detail 9738 C57BL/6J ±  kb
transcript ENSMUST00000026462 Ensembl | MGI Sequence Detail 1392 Not Applicable 
polypeptide ENSMUSP00000026462 Ensembl | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(14) UniProt(1)
Polymorphisms
SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000008782 17-beta-hydroxysteroid dehydrogenase type 6
References
(Earliest) J:58333 Su J, et al., Complementary deoxyribonucleic acid cloning and enzymatic characterization of a novel 17beta/3alpha-hydroxysteroid/retinoid short chain dehydrogenase/reductase. Endocrinology. 1999 Nov;140(11):5275-84
(Latest) J:216177 Labialle S, et al., The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 2014 Oct 1;33(19):2216-30
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory