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Hsd17b6 Gene Detail
Summary
  • Symbol
    Hsd17b6
  • Name
    hydroxysteroid (17-beta) dehydrogenase 6
  • Synonyms
    17betaHSD9, Hsd17b9, Rdh8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351670
    NCBI Gene: 27400
  • Gene Overview
    MyGene.info: HSD17B6
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127990936-128007611 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 76.39 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351670
protein coding gene Chr10:127990933-128007632 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017843
protein coding gene Chr10:131653792-131674342 (-)
A/J MGP_AJ_G0017818
protein coding gene Chr10:126391705-126413671 (-)
AKR/J MGP_AKRJ_G0017781
protein coding gene Chr10:130115076-130126470 (-)
BALB/cJ MGP_BALBcJ_G0017782
protein coding gene Chr10:126778975-126788768 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0018237
protein coding gene Chr10:136123440-136134169 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015915
protein coding gene Chr10:120354981-120366949 (-)
CAST/EiJ MGP_CASTEiJ_G0017166
protein coding gene Chr10:130974134-130996826 (-)
CBA/J MGP_CBAJ_G0017575
protein coding gene Chr10:141653126-141662712 (-)
DBA/2J MGP_DBA2J_G0017681
protein coding gene Chr10:125468526-125475654 (-)
FVB/NJ MGP_FVBNJ_G0017676
protein coding gene Chr10:124402772-124412500 (-)
LP/J MGP_LPJ_G0017755
protein coding gene Chr10:132271759-132286009 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017704
protein coding gene Chr10:144257025-144275846 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018277
protein coding gene Chr10:130204461-130215562 (-)
PWK/PhJ MGP_PWKPhJ_G0016951
protein coding gene Chr10:125698020-125718247 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016740
protein coding gene Chr10:129290279-129308554 (-)
WSB/EiJ MGP_WSBEiJ_G0017225
protein coding gene Chr10:130423913-130440498 (-)



Homology
more
  • Human Ortholog
    HSD17B6, hydroxysteroid 17-beta dehydrogenase 6
  • Vertebrate Orthologs
    5
  • Human Ortholog
    HSD17B6, hydroxysteroid 17-beta dehydrogenase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSE, RODH, SDR9C6
  • Links
    NCBI Gene ID: 8630
    neXtProt AC: NX_O14756
    UniProt: O14756

  • Chr Location
    12q13.3; chr12:56752449-56787790 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025396 Ensembl Gene Model | MGI Sequence Detail 16676 C57BL/6J ±  kb
transcript ENSMUST00000026462 Ensembl | MGI Sequence Detail 1392 Not Applicable  
polypeptide ENSMUSP00000026462 Ensembl | MGI Sequence Detail 317 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 5
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 1
  • Earliest
    J:58333 Su J, et al., Complementary deoxyribonucleic acid cloning and enzymatic characterization of a novel 17beta/3alpha-hydroxysteroid/retinoid short chain dehydrogenase/reductase. Endocrinology. 1999 Nov;140(11):5275-84
  • Latest
    J:216177 Labialle S, et al., The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 2014 Oct 1;33(19):2216-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory