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Foxc1 Gene Detail
Summary
  • Symbol
    Foxc1
  • Name
    forkhead box C1
  • Synonyms
    fkh1, fkh-1, Fkh1, FREAC3, frkhda, Mf1, Mf4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347466
    NCBI Gene: 17300
  • Gene Overview
    MyGene.info: FOXC1
Location & Maps
more
  • Sequence Map
    Chr13:31806691-31810643 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3953 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 13.52 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    FOXC1, forkhead box C1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    FOXC1, forkhead box C1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARA, FKHL7, FREAC3, FREAC-3, IGDA, IHG1, IRID1, RIEG3
  • Links
    NCBI Gene ID: 2296
    neXtProt AC: NX_Q12948

  • Chr Location
    6p25; chr6:1610446-1613897 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Foxc1 mouse models; 2 with human FOXC1 associations

Human Disease Mouse Models
       Glaucoma 3, Primary Congenital, A; GLC3A   OMIM: 231300 View 2 models
       Axenfeld-Rieger Syndrome, Type 3; RIEG3   OMIM: 602482
Iridogoniodysgenesis, Type 1; IRID1   OMIM: 601631
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    206 phenotypes from 5 alleles in 15 genetic backgrounds
    63 phenotypes from multigenic genotypes
    4 images
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Foxc1
  • Incidental Mutations
Homozygous mutants are neonatal lethal with congenital hydrocephalus, edema, abnormalities of the eye, skull, axial skeleton, kidney-ureter and cardiovascular systems. Heterozygotes have variable milder defects depending on genetic background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000725 VEGA Gene Model | MGI Sequence Detail 3953 C57BL/6J ±  kb
transcript OTTMUST00000001359 VEGA | MGI Sequence Detail 3953 Not Applicable  
polypeptide OTTMUSP00000000642 VEGA | MGI Sequence Detail 553 Not Applicable  
For the selected sequence
Polymorphisms
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  • PCR
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007607 forkhead box protein C1
  • InterPro Domains
    IPR001766 Fork head domain
    IPR018122 Fork head domain conserved site1
    IPR030456 Fork head domain conserved site 2
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 58
    Genomic 8
    cDNA 43
    Primer pair 3
    Other 4

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-16690, MGD-MRK-1966, MGD-MRK-24021, MGD-MRK-35060, MGD-MRK-9813, MGI:103155, MGI:88391, MGI:95544
References
more
  • Summaries
    All 139
    Developmental Gene Expression 74
    Diseases 1
    Gene Ontology 28
    Phenotypes 55
  • Earliest
    J:75733 Gruneberg H, Congenital hydrocephalus in the mouse, a case of spurious pleiotropism. J Genet. 1943;45(1):1-21
  • Latest
    J:229528 Wang L, et al., Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science. 2016 Feb 5;351(6273):613-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory