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Foxc1
Gene Detail
Symbol

Name
ID
Foxc1
forkhead box C1
MGI:1347466
Synonyms
fkh1, fkh-1, Fkh1, FREAC3, frkhda, Mf1, Mf4
Feature Type
protein coding gene
Genetic Map
Chromosome 13
13.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr13:31806691-31810643 bp, + strand
From VEGA annotation of GRCm38

  3953 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20373  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOXC1
Gene Tree: Foxc1

Human
homologs
FOXC1, forkhead box C1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2296
neXtProt AC: NX_Q12948

Human Synonyms: ARA, FKHL7, FREAC3, FREAC-3, IGDA, IHG1, IRID1, RIEG3

Human Chr (Location): 6p25; chr6:1610446-1613897 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human FOXC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Radiation induced(1) Spontaneous(1) Targeted(3)
Genomic Mutations involving Foxc1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants are neonatal lethal with congenital hydrocephalus, edema, abnormalities of the eye, skull, axial skeleton, kidney-ureter and cardiovascular systems. Heterozygotes have variable milder defects depending on genetic background.
 
Human Diseases Modeled in Mice Using Foxc1 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Foxc1 interacts with 290 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (70 annotations)
Process artery morphogenesis, blood vessel development, ...
Component cytoplasm, nuclear heterochromatin, ...
Function DNA binding, DNA binding, bending, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (574)    Tissues (286)    Images (104)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 343
In situ reporter (knock in) 122
Northern blot 34
RT-PCR 36
RNase protection 39
cDNA source data(42)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase foxc1 ; ZFIN foxc1a, foxc1b    NEW 
Molecular
reagents
All nucleic(57) Genomic(8) cDNA(43) Primer pair(3) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000725 (Evidence)
Ensembl Gene Model ENSMUSG00000050295 (Evidence)
Entrez Gene 17300 (Evidence)
UniGene 12949
DFCI TC1668582, TC1662755, TC1580884
DoTS DT.101346600, DT.485929, DT.94354889
NIA Mouse Gene Index U014701
Consensus CDS Project CCDS26425.1
International Mouse Phenotyping Consortium Status Foxc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000725 VEGA Gene Model | MGI Sequence Detail 3953 C57BL/6J ±  kb
transcript OTTMUST00000001359 VEGA | MGI Sequence Detail 3953 Not Applicable 
polypeptide OTTMUSP00000000642 VEGA | MGI Sequence Detail 553 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(0 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007607 forkhead box protein C1
References
(Earliest) J:75733 Gruneberg H, Congenital hydrocephalus in the mouse, a case of spurious pleiotropism. J Genet. 1943;45(1):1-21
(Latest) J:213620 Kong P, et al., Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication. Hum Mol Genet. 2014 Aug 15;23(16):4215-31
All references(134)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16690, MGD-MRK-1966, MGD-MRK-24021, MGD-MRK-35060, MGD-MRK-9813, MGI:103155, MGI:88391, MGI:95544

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory