Foxc1
Gene Detail

Symbol Name ID

Foxc1 forkhead box C1 MGI:1347466

Synonyms

fkh1, fkh-1, Fkh1, FREAC3, frkhda, Mf1, Mf4

Feature Type

protein coding gene

Genetic Map

Chromosome 13

13.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr13:31806691-31810643 bp, + strand From VEGA annotation of GRCm38   3953 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20373  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 zebrafish

Gene Tree: Foxc1

Human homologs

Human Homolog		FOXC1, forkhead box C1
NCBI Gene ID		2296
neXtProt AC		NX_Q12948
Human Synonyms		ARA, FKHL7, FREAC3, FREAC-3, IGDA, IHG1, IRID1, RIEG3
Human Chr (Location)		6p25; chr6:1610681-1614132 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human FOXC1

Alleles and phenotypes

All alleles(5) : Targeted(3) Spontaneous(1) Chemically induced(1)
 

Homozygous mutants are neonatal lethal with congenital hydrocephalus, edema, abnormalities of the eye, skull, axial skeleton, kidney-ureter and cardiovascular systems. Heterozygotes have variable milder defects depending on genetic background.

 
Human Diseases Modeled Using Mouse Foxc1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (70 annotations)

Process	artery morphogenesis, blood vessel development, ...
Component	cytoplasm, nuclear heterochromatin, ...
Function	chromatin DNA binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (61 records)
Data Summary: Results (503)    Tissues (226)    Images (91)
Theiler Stages: 2, 3, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	351
In situ reporter (knock in)	43
Northern blot	34
RT-PCR	36
RNase protection	39

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(8) cDNA(16) Primer pair(3) Other(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000000725 (Evidence)
Ensembl Gene Model	ENSMUSG00000050295 (Evidence)
Entrez Gene	17300 (Evidence)
DFCI	TC1580884, TC1662755, TC1668582
DoTS	DT.485929, DT.101346600, DT.94354889
NIA Mouse Gene Index	U014701
Consensus CDS Project	CCDS26425.1
International Mouse Knockout Project Status	Foxc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000725	VEGA Gene Model | MGI Sequence Detail	3953	C57BL/6J
transcript	OTTMUST00000001359	VEGA | MGI Sequence Detail	3953	Not Applicable
polypeptide	OTTMUSP00000000642	VEGA | MGI Sequence Detail	553	Not Applicable

All sequences(27) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(0 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000007607	forkhead box protein C1

References

(Earliest) J:75733 Gruneberg H, Congenital hydrocephalus in the mouse, a case of spurious pleiotropism. J Genet. 1943;45(1):1-21
(Latest) J:194058 Sun J, et al., Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2. Development. 2013 Mar;140(5):1034-44
All references(122)

Other accession IDs

MGD-MRK-16690, MGD-MRK-1966, MGD-MRK-24021, MGD-MRK-35060, MGD-MRK-9813, MGI:103155, MGI:88391, MGI:95544