Foxc1^tm1Blh
Targeted Allele Detail

Summary

• Symbol: Foxc1^tm1Blh
• Name: forkhead box C1; targeted mutation 1, Brigid L Hogan
• MGI ID: MGI:1857869
• Synonyms: Foxc1-, Foxc1^Lacz, Mf1^-, Mf1^lacZ
• Gene: Foxc1 Location: Chr13:31990629-31994618 bp, + strand Genetic Position: Chr13, 13.52 cM
• Alliance: Foxc1^tm1Blh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48079
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ- neomycin resistance cassette replaced sequences encoding amino acids 90-553 and most of the 3' untranslated region. A beta galactosidase fusion protein is expressed from this allele. (J:48079)

Disease models

Expression

In Mice Carrying this Mutation:	293 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	49 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxc1 Mutation: 29 strains or lines available

References

• Original: J:48079 Kume T, et al., The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus. Cell. 1998 Jun 12;93(6):985-96
• All: 31 reference(s)