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Symbol
Name
ID

Foxc1
forkhead box C1
MGI:1347466

Phenotype annotations related to craniofacial

Darker colors indicate more annotations

Human Phenotypes	Hypoplasia of the maxilla	Malar flattening	Midface retrusion	Prominent forehead	Everted lower lip vermilion	Microdontia	Hypodontia	Concave nasal ridge	Depressed nasal bridge	Wide nasal bridge	Telecanthus
Disease(s) Associated with FOXC1	Hypoplasia of the maxilla	Malar flattening	Midface retrusion	Prominent forehead	Everted lower lip vermilion	Microdontia	Hypodontia	Concave nasal ridge	Depressed nasal bridge	Wide nasal bridge	Telecanthus
Axenfeld-Rieger syndrome
Axenfeld-Rieger syndrome type 3

Mouse Phenotypes

abnormal pharyngeal arch artery morphology

abnormal fourth pharyngeal arch artery morphology

abnormal craniofacial bone morphology

small basisphenoid bone

abnormal foramen magnum morphology

short basicranium

small Meckel's cartilage

abnormal neurocranium morphology

abnormal frontal bone morphology

absent frontal bone

abnormal occipital bone morphology

abnormal sphenoid bone morphology

absent neurocranium

abnormal hyoid bone morphology

short mandible

abnormal maxillary zygomatic process morphology

enlarged maxillary zygomatic process

abnormal craniofacial development

abnormal Reichert's cartilage morphology

abnormal nasal capsule morphology

short snout

Availability

Mouse Genotype

Foxc1^ch/Foxc1^ch

Foxc1^hith/Foxc1^hith

Foxc1^tm1Blh/Foxc1^tm1Blh

Foxc1^ch/Foxc1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23