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Tjp2
Gene Detail
Symbol

Name
ID
Tjp2
tight junction protein 2
MGI:1341872
Synonyms
ZO-2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
19.17 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:24094523-24225026 bp, - strand
From Ensembl annotation of GRCm38

  130504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3541  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tjp2

Human
homologs
Human Homolog TJP2, tight junction protein 2
NCBI Gene ID 9414
neXtProt AC  NX_Q9UDY2
Human Synonyms  C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2
Human Chr (Location)  9q13-q21; chr9:69099959-69255208 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TJP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(709) : Gene trapped(707) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality shortly after implantation due to arrest in early gastrulation. Structure and permeability barrier of the apical junctional complex are altered in cells.
 
Interactions
Tjp2 interacts with 213 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Component cell junction, cell surface, ...
Function protein binding, protein C-terminus binding
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (81)    Tissues (69)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
RNA in situ 54
Western blot 3
cDNA source data(164)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(165) cDNA(165)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000024812 (Evidence)
Entrez Gene21873 (Evidence)
UniGene104744
DFCITC1575195, TC1696668, TC1754850
DoTSDT.101736710, DT.55101050
NIA Mouse Gene IndexU038923
PDB2CSJ
Consensus CDS ProjectCCDS37939.1
International Mouse Knockout Project StatusTjp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024812 Ensembl Gene Model | MGI Sequence Detail 130504 C57BL/6J ±  kb
transcript ENSMUST00000099558 Ensembl | MGI Sequence Detail 4591 Not Applicable 
polypeptide ENSMUSP00000097154 Ensembl | MGI Sequence Detail 1167 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(16) UniProt(1)
Polymorphisms
SNPs within 2kb(1481 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1483)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
InterPro IPR005417 Zona occludens protein
InterPro IPR005419 Zona occludens protein ZO-2
Protein Ontology PR:000016365 tight junction protein ZO-2
References
(Earliest) J:53203 Itoh M, et al., Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J Biol Chem. 1999 Feb 26;274(9):5981-6
(Latest) J:194042 Mahaffey JP, et al., Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013 Mar;140(6):1262-71
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory