Tjp2
Gene Detail

Symbol Name ID

Tjp2 tight junction protein 2 MGI:1341872

Synonyms

ZO-2

Feature Type

protein coding gene

Genetic Map

Chromosome 19

19.17 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:24094523-24225026 bp, - strand From Ensembl annotation of GRCm38   130504 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3541  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tjp2

Human homologs

Human Homolog		TJP2, tight junction protein 2
NCBI Gene ID		9414
neXtProt AC		NX_Q9UDY2
Human Synonyms		C9DUPq21.11, DFNA51, DUP9q21.11, X104, ZO2
Human Chr (Location)		9q13-q21; chr9:71736180-71870124 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TJP2

Alleles and phenotypes

All alleles(709) : Targeted(2) Gene trapped(707)
 

Homozygous mutation of this gene results in lethality shortly after implantation due to arrest in early gastrulation. Structure and permeability barrier of the apical junctional complex are altered in cells.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Component	cell junction, cell surface, ...
Function	protein binding, protein C-terminus binding

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (81)    Tissues (69)    Images (4)
Theiler Stages: 13, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	24
RNA in situ	54
Western blot	3

cDNA source data(164)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(165) cDNA(165)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000024812 (Evidence)
Entrez Gene	21873 (Evidence)
UniGene	104744
DFCI	TC1575195, TC1696668, TC1754850
DoTS	DT.101736710, DT.55101050
NIA Mouse Gene Index	U038923
PDB	2CSJ
Consensus CDS Project	CCDS37939.1
International Mouse Knockout Project Status	Tjp2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024812	Ensembl Gene Model | MGI Sequence Detail	130504	C57BL/6J
transcript	ENSMUST00000099558	Ensembl | MGI Sequence Detail	4591	Not Applicable
polypeptide	ENSMUSP00000097154	Ensembl | MGI Sequence Detail	1167	Not Applicable

All sequences(45) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(754 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008144	Guanylate kinase
InterPro	IPR008145	Guanylate kinase/L-type calcium channel
InterPro	IPR001478	PDZ domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR011511	Variant SH3
InterPro	IPR005417	Zona occludens protein
InterPro	IPR005419	Zona occludens protein ZO-2
Protein Ontology	PR:000016365	tight junction protein ZO-2

References

(Earliest) J:53203 Itoh M, et al., Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J Biol Chem. 1999 Feb 26;274(9):5981-6
(Latest) J:194042 Mahaffey JP, et al., Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013 Mar;140(6):1262-71
All references(59)