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Tjp2 Gene Detail
Summary
  • Symbol
    Tjp2
  • Name
    tight junction protein 2
  • Synonyms
    ZO-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341872
    NCBI Gene: 21873
  • Gene Overview
    MyGene.info: TJP2
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:24094523-24225026 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 19.17 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1477 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341872
protein coding gene Chr19:24094502-24225130 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024992
protein coding gene Chr19:22290421-22374925 (-)
A/J MGP_AJ_G0024969
protein coding gene Chr19:21071621-21119842 (-)
AKR/J MGP_AKRJ_G0024939
protein coding gene Chr19:21876383-21924625 (-)
BALB/cJ MGP_BALBcJ_G0024968
protein coding gene Chr19:21110074-21252134 (-)
C3H/HeJ MGP_C3HHeJ_G0024725
protein coding gene Chr19:21826506-21875917 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025409
protein coding gene Chr19:22994328-23141958 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022828
protein coding gene Chr19:21248439-21379421 (-)
CAST/EiJ MGP_CASTEiJ_G0024194
protein coding gene Chr19:21574535-21661930 (-)
CBA/J MGP_CBAJ_G0024703
protein coding gene Chr19:24012492-24067424 (-)
DBA/2J MGP_DBA2J_G0024835
protein coding gene Chr19:21075888-21124558 (-)
FVB/NJ MGP_FVBNJ_G0024796
protein coding gene Chr19:20939873-21077495 (-)
LP/J MGP_LPJ_G0024919
protein coding gene Chr19:22242786-22324871 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024823
protein coding gene Chr19:24043976-24187566 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025464
protein coding gene Chr19:21876537-22014568 (-)
PWK/PhJ MGP_PWKPhJ_G0023942
protein coding gene Chr19:20677427-20758041 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023747
protein coding gene Chr19:21101322-21191699 (-)
WSB/EiJ MGP_WSBEiJ_G0024261
protein coding gene Chr19:21895967-21978546 (-)



Homology
more
  • Human Ortholog
    TJP2, tight junction protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TJP2, tight junction protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2
  • Links
    NCBI Gene ID: 9414
    neXtProt AC: NX_Q9UDY2
    UniProt: Q9UDY2

  • Chr Location
    9q21.11; chr9:69099907-69255208 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3541
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TJP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality shortly after implantation due to arrest in early gastrulation. Structure and permeability barrier of the apical junctional complex are altered in cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024812 Ensembl Gene Model | MGI Sequence Detail 130504 C57BL/6J ±  kb
    transcript ENSMUST00000233658 Ensembl | MGI Sequence Detail 4920 Not Applicable  
    polypeptide ENSMUSP00000156728 Ensembl | MGI Sequence Detail 1258 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 166
      cDNA 166

      Microarray probesets 5
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 26
      Gene Ontology 12
      Phenotypes 12
    • Earliest
      J:53203 Itoh M, et al., Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J Biol Chem. 1999 Feb 26;274(9):5981-6
    • Latest
      J:244106 Lin C, et al., YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. Elife. 2017 Mar 21;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory