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Tjp2
Gene Detail
Symbol

Name
ID
Tjp2
tight junction protein 2
MGI:1341872
Synonyms
ZO-2
Feature Type
protein coding gene
Genetic Map
Chromosome 19
19.17 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:24094523-24225026 bp, - strand
From Ensembl annotation of GRCm38

  130504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3541  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TJP2
Gene Tree: Tjp2

Human
homologs
TJP2, tight junction protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9414
neXtProt AC: NX_Q9UDY2

Human Synonyms: C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2

Human Chr (Location): 9q13-q21; chr9:69121264-69255208 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TJP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(709) : Gene trapped(707) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in lethality shortly after implantation due to arrest in early gastrulation. Structure and permeability barrier of the apical junctional complex are altered in cells.
 
Interactions
Tjp2 interacts with 212 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process establishment of endothelial intestinal barrier, intestinal absorption, ...
Component bicellular tight junction, cell junction, ...
Function protein binding, protein binding, bridging, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (80)    Tissues (68)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 24
RNA in situ 53
Western blot 3
cDNA source data(164)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tjp2 ; ZFIN tjp2a    NEW 
Molecular
reagents
All nucleic(165) cDNA(165)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000024812 (Evidence)
Entrez Gene 21873 (Evidence)
UniGene 104744
DFCI TC1575195, TC1696668, TC1754850
DoTS DT.101736710, DT.55101050
NIA Mouse Gene Index U038923
PDB 2CSJ
Consensus CDS Project CCDS37939.1
International Mouse Phenotyping Consortium Status Tjp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024812 Ensembl Gene Model | MGI Sequence Detail 130504 C57BL/6J ±  kb
transcript ENSMUST00000099558 Ensembl | MGI Sequence Detail 4591 Not Applicable 
polypeptide ENSMUSP00000097154 Ensembl | MGI Sequence Detail 1167 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(16) UniProt(1)
Polymorphisms
SNPs within 2kb(1481 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1483)
Protein-related
information
ResourceIDDescription
InterPro IPR008144 Guanylate kinase-like domain
InterPro IPR008145 Guanylate kinase/L-type calcium channel beta subunit
InterPro IPR001478 PDZ domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 SH3 domain
InterPro IPR005417 Tight junction protein ZO
InterPro IPR005419 Tight junction protein ZO-2
InterPro IPR011511 Variant SH3 domain
Protein Ontology PR:000016365 tight junction protein ZO-2
References
(Earliest) J:53203 Itoh M, et al., Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin. J Biol Chem. 1999 Feb 26;274(9):5981-6
(Latest) J:220469 Grego-Bessa J, et al., Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains. Development. 2015 Apr 1;142(7):1305-14
All references(63)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory