Tjp1^tm1.1Whun
Targeted Allele Detail

Summary

• Symbol: Tjp1^tm1.1Whun
• Name: tight junction protein 1; targeted mutation 1.1, Walter Hunziker
• MGI ID: MGI:5749399
• Synonyms: Tjp1^flox
• Gene: Tjp1 Location: Chr7:64945913-65177529 bp, - strand Genetic Position: Chr7, 35.02 cM
• Alliance: Tjp1^tm1.1Whun page

Growth retardation and severe glomerulosclerosis in Tjp1^tm1.1Whun/Tjp1^tm1.1WhunTg(Nphs1-cre)33Mska/0 mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226210
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 4. An F3 site flanked pyromycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection markers and left exon 4 floxed. (J:226210)

Generation of the Tjp1^tm1.1Whun allele

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tjp1 Mutation: 43 strains or lines available

References

• Original: J:226210 Itoh M, et al., The structural and functional organization of the podocyte filtration slits is regulated by Tjp1/ZO-1. PLoS One. 2014;9(9):e106621
• All: 3 reference(s)