About   Help   FAQ
Phenotype Images associated with this Allele
Nomenclature
Symbol: Tjp1tm1.1Whun
Name: tight junction protein 1; targeted mutation 1.1, Walter Hunziker
MGI ID: MGI:5749399
Synonyms: Tjp1flox
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Growth retardation and severe glomerulosclerosis in Tjp1tm1.1Whun/Tjp1tm1.1WhunTg(Nphs1-cre)33Mska/0 miceTjp1tm1.1Whun/Tjp1tm1.1Whun
Tg(Nphs1-cre)33Mska/0		involves: C57BL/6 * C57BL/6N * DBA/2
Compromised foot process interdigitation and aberrant distribution of the slit diaphragm components in Tjp1tm1.1Whun/Tjp1tm1.1Whun Tg(Nphs1-cre)33Mska/0 miceTjp1tm1.1Whun/Tjp1tm1.1Whun
Tg(Nphs1-cre)33Mska/0		involves: C57BL/6 * C57BL/6N * DBA/2
Slit diaphragms are absent in the maturing stage of Tjp1tm1.1Whun/Tjp1tm1.1WhunTg(Nphs1-cre)33Mska/0 podocytesTjp1tm1.1Whun/Tjp1tm1.1Whun
Tg(Nphs1-cre)33Mska/0		involves: C57BL/6 * C57BL/6N * DBA/2
Defects in the glomerulus, dilated renal tubules, global foot process effacement and absent slit diaphragm in Tjp1tm1.1Whun/Tjp1tm1.1Whun Tg(Nphs1-cre)33Mska/0 miceTjp1tm1.1Whun/Tjp1tm1.1Whun
Tg(Nphs1-cre)33Mska/0		involves: C57BL/6 * C57BL/6N * DBA/2
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory