Tjp2 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tjp2
tight junction protein 2
MGI:1341872

18 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Tjp1^tm1.1Whun/Tjp1^tm1.1Whun Tjp2^tm2Whun/Tjp2^tm2Whun Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * C57BL/6NTac * DBA/2	abnormal bile canaliculus morphology	J:306936
	abnormal hepatic cord morphology	J:306936
	abnormal hepatic duct morphology	J:306936
	abnormal hepatocyte morphology	J:306936
	abnormal liver morphology	J:306936
	abnormal liver physiology	J:306936
	abnormal liver sinusoid morphology	J:306936
	increased bile salt level	J:306936
	increased circulating alanine transaminase level	J:306936
	increased circulating alkaline phosphatase level	J:306936
	increased circulating aspartate transaminase level	J:306936
	increased circulating bilirubin level	J:306936
	increased circulating LDL cholesterol level	J:306936
	increased hepatocyte proliferation	J:306936
	increased liver weight	J:306936
	postnatal lethality, incomplete penetrance	J:306936
	premature death	J:306936
	small liver	J:306936

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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