About   Help   FAQ
Kcnq3 Gene Detail
Summary
  • Symbol
    Kcnq3
  • Name
    potassium voltage-gated channel, subfamily Q, member 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336181
    NCBI Gene: 110862
  • Gene Overview
    MyGene.info: KCNQ3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:65986390-66286636 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 29.16 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3015 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336181
protein coding gene Chr15:65986387-66286642 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021903
protein coding gene Chr15:65487279-65784477 (-)
A/J MGP_AJ_G0021862
protein coding gene Chr15:62993853-63287071 (-)
AKR/J MGP_AKRJ_G0021844
protein coding gene Chr15:64750809-65037025 (-)
BALB/cJ MGP_BALBcJ_G0021869
protein coding gene Chr15:63177755-63473610 (-)
C3H/HeJ MGP_C3HHeJ_G0021642
protein coding gene Chr15:64864951-65162469 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022308
protein coding gene Chr15:68027185-68337231 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019845
protein coding gene Chr15:59795391-60079849 (-)
CAST/EiJ MGP_CASTEiJ_G0021161
protein coding gene Chr15:65495911-65808647 (-)
CBA/J MGP_CBAJ_G0021608
protein coding gene Chr15:70303545-70617314 (-)
DBA/2J MGP_DBA2J_G0021733
protein coding gene Chr15:62786028-63081022 (-)
FVB/NJ MGP_FVBNJ_G0021715
protein coding gene Chr15:61827453-62111646 (-)
LP/J MGP_LPJ_G0021805
protein coding gene Chr15:65365449-65674809 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021738
protein coding gene Chr15:75394261-75701060 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022330
protein coding gene Chr15:65123264-65420385 (-)
PWK/PhJ MGP_PWKPhJ_G0020902
protein coding gene Chr15:62865449-63161849 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020743
protein coding gene Chr15:64964741-65265087 (-)
WSB/EiJ MGP_WSBEiJ_G0021213
protein coding gene Chr15:65090542-65392869 (-)



Homology
more
  • Human Ortholog
    KCNQ3, potassium voltage-gated channel subfamily Q member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNQ3, potassium voltage-gated channel subfamily Q member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BFNC2, EBN2, KV7.3
  • Links
    NCBI Gene ID: 3786
    neXtProt AC: NX_O43525
    UniProt: O43525

  • Chr Location
    8q24.22; chr8:132120858-132480757 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Kcnq3 mouse models; 1 with human KCNQ3 associations

Human Disease Mouse Models
      
IDs
View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 6 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal apamin-insensitive afterhyperpolarization currents in granule cells, but not pyramidal cells, of the hippocampus. Mice homozygous for a knock-in allele exhibit spontaneous seizures and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110862 NCBI Gene Model | MGI Sequence Detail 300247 C57BL/6J ±  kb
    transcript NM_152923 RefSeq | MGI Sequence Detail 2878 C57BL/6  
    polypeptide Q8K3F6 UniProt | EBI | MGI Sequence Detail 873 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:242531 Bedogni F, et al., Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms. Cereb Cortex. 2016 Jun;26(6):2517-2529

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory