About   Help   FAQ
Kcnq3
Gene Detail
Symbol

Name
ID
Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
MGI:1336181
Feature Type
protein coding gene
Genetic Map
Chromosome 15
29.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:65986387-66286224 bp, - strand
From VEGA annotation of GRCm38

  299838 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20949  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KCNQ3
Protein SuperFamily: potassium voltage-gated channel, subfamily KQT
Gene Tree: Kcnq3

Human
homologs
KCNQ3, potassium channel, voltage gated KQT-like subfamily Q, member 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3786
neXtProt AC: NX_O43525

Human Synonyms: BFNC2, EBN2, KV7.3

Human Chr (Location): 8q24; chr8:132120858-132480757 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KCNQ3

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Kcnq3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit abnormal apamin-insensitive afterhyperpolarization currents in granule cells, but not pyramidal cells, of the hippocampus. Mice homozygous for a knock-in allele exhibit spontaneous seizures and premature death.
 
Human Diseases Modeled in Mice Using Kcnq3 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Kcnq3 interacts with 6 markers (Mir223, Mir367, Mir875, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cellular response to ammonium ion, ion transmembrane transport, ...
Component axon initial segment, cell surface, ...
Function calmodulin binding, delayed rectifier potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (69)    Tissues (16)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 60
RT-PCR 9
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(7) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000044954 (Evidence)
Ensembl Gene Model ENSMUSG00000056258 (Evidence)
Entrez Gene 110862 (Evidence)
UniGene 255585
DFCI TC1601991
DoTS DT.40170057
NIA Mouse Gene Index U125543
Consensus CDS Project CCDS49619.1
International Mouse Phenotyping Consortium Status Kcnq3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044954 VEGA Gene Model | MGI Sequence Detail 299838 C57BL/6J ±  kb
transcript OTTMUST00000118148 VEGA | MGI Sequence Detail 11406 Not Applicable 
polypeptide OTTMUSP00000065972 VEGA | MGI Sequence Detail 873 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(5) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(3025 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3033)
Protein-related
information
ResourceIDDescription
InterPro IPR020969 Ankyrin-G binding site
InterPro IPR005821 Ion transport domain
InterPro IPR003937 Potassium channel, voltage dependent, KCNQ
InterPro IPR003948 Potassium channel, voltage dependent, KCNQ3
InterPro IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminal
InterPro IPR003091 Voltage-dependent potassium channel
Protein Ontology PR:000000730 voltage-gated potassium channel subunit KCNQ3
References
(Earliest) J:54001 McCormack T, et al., Chromosomal mapping of the potassium channel genes Kcnq2 and Kcnq3 in mouse. Genomics. 1999 Mar 15;56(3):360-1
(Latest) J:208109 Soh H, et al., Conditional Deletions of Epilepsy-Associated KCNQ2 and KCNQ3 Channels from Cerebral Cortex Cause Differential Effects on Neuronal Excitability. J Neurosci. 2014 Apr 9;34(15):5311-21
All references(36)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory