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Pik3r2
Gene Detail
Symbol

Name
ID
Pik3r2
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
MGI:1098772
Synonyms
p85beta
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:70768176-70776713 bp, - strand
From VEGA annotation of GRCm38

  8538 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3687  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: phosphatidylinositol 3-kinase, regulatory subunit, p85 type
Gene Tree: Pik3r2

Human
homologs
Human Homolog PIK3R2, phosphoinositide-3-kinase, regulatory subunit 2 (beta)
NCBI Gene ID 5296
neXtProt AC  NX_O00459
Human Synonyms  MPPH, MPPH1, p85, P85B, p85-BETA
Human Chr (Location)  19q13.2-q13.4; chr19:18153178-18170533 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PIK3R2
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have lower blood glucose levels both when fed and after fasting. Insulin sensitivity is improved as well.
 
Interactions
Pik3r2 interacts with 68 markers (Mir23b, Mir27a, Mir30a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (155)    Tissues (114)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 25
RT-PCR 36
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) cDNA(78) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000032469 (Evidence)
Ensembl Gene ModelENSMUSG00000031834 (Evidence)
Entrez Gene18709 (Evidence)
UniGene12945
DFCITC1577167
DoTSDT.110878733, DT.489669
NIA Mouse Gene IndexU029930
PDB2Y3A
Consensus CDS ProjectCCDS22381.1
International Mouse Knockout Project StatusPik3r2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032469 VEGA Gene Model | MGI Sequence Detail 8538 C57BL/6J ±  kb
transcript OTTMUST00000080755 VEGA | MGI Sequence Detail 3165 Not Applicable 
polypeptide OTTMUSP00000043037 VEGA | MGI Sequence Detail 722 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001720 PI3 kinase, P85 regulatory subunit
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000012725 phosphatidylinositol 3-kinase regulatory subunit beta
References
(Earliest) J:36742 Pons S, et al., The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol. 1995 Aug;15(8):4453-65
(Latest) J:193238 Katholnig K, et al., p38alpha Senses Environmental Stress To Control Innate Immune Responses via Mechanistic Target of Rapamycin. J Immunol. 2013 Feb 15;190(4):1519-27
All references(67)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory