Pik3r2
Gene Detail

Symbol Name ID

Pik3r2 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) MGI:1098772

Synonyms

p85beta

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:70768176-70776713 bp, - strand From VEGA annotation of GRCm38   8538 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3687  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phosphatidylinositol 3-kinase, regulatory subunit, p85 type
Gene Tree: Pik3r2

Human homologs

Human Homolog		PIK3R2, phosphoinositide-3-kinase, regulatory subunit 2 (beta)
NCBI Gene ID		5296
neXtProt AC		NX_O00459
Human Synonyms		MPPH, p85, P85B, p85-BETA
Human Chr (Location)		19q13.2-q13.4; chr19:18264016-18281343 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PIK3R2

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene have lower blood glucose levels both when fed and after fasting. Insulin sensitivity is improved as well.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	insulin receptor signaling pathway, regulation of phosphorylation, ...
Component	intracellular, phosphatidylinositol 3-kinase complex
Function	1-phosphatidylinositol-3-kinase activity, phosphatidylinositol 3-kinase regulator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (155)    Tissues (114)   
Theiler Stages: 2, 3, 21, 22, 25, 28

Assay Type	Results
RNA in situ	94
Northern blot	25
RT-PCR	36

cDNA source data(78)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(79) cDNA(78) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000032469 (Evidence)
Ensembl Gene Model	ENSMUSG00000031834 (Evidence)
Entrez Gene	18709 (Evidence)
UniGene	12945
DFCI	TC1577167
DoTS	DT.110878733, DT.489669
NIA Mouse Gene Index	U029930
PDB	2Y3A
Consensus CDS Project	CCDS22381.1
International Mouse Knockout Project Status	Pik3r2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032469	VEGA Gene Model | MGI Sequence Detail	8538	C57BL/6J
transcript	OTTMUST00000080755	VEGA | MGI Sequence Detail	3165	Not Applicable
polypeptide	OTTMUSP00000043037	VEGA | MGI Sequence Detail	722	Not Applicable

All sequences(47) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001720	PI3 kinase, P85 regulatory subunit
InterPro	IPR000198	Rho GTPase-activating protein domain
InterPro	IPR008936	Rho GTPase activation protein
InterPro	IPR000980	SH2 domain
InterPro	IPR001452	Src homology-3 domain
Protein Ontology	PR:000012725	phosphatidylinositol 3-kinase regulatory subunit beta

References

(Earliest) J:36742 Pons S, et al., The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol. 1995 Aug;15(8):4453-65
(Latest) J:193238 Katholnig K, et al., p38alpha Senses Environmental Stress To Control Innate Immune Responses via Mechanistic Target of Rapamycin. J Immunol. 2013 Feb 15;190(4):1519-27
All references(65)