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Pik3r2
Gene Detail
Symbol

Name
ID
Pik3r2
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
MGI:1098772
Synonyms
p85beta
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:70768176-70776713 bp, - strand
From VEGA annotation of GRCm38

  8538 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3687  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIK3R2
Protein SuperFamily: phosphatidylinositol 3-kinase, regulatory subunit, p85 type
Gene Tree: Pik3r2

Human
homologs
PIK3R2, phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5296
neXtProt AC: NX_O00459

Human Synonyms: MPPH, MPPH1, p85, P85B, p85-BETA

Human Chr (Location): 19q13.2-q13.4; chr19:18153178-18170533 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PIK3R2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have lower blood glucose levels both when fed and after fasting. Insulin sensitivity is improved as well.
 
Interactions
Pik3r2 interacts with 68 markers (Mir23b, Mir27a, Mir30a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (155)    Tissues (114)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 25
RT-PCR 36
cDNA source data(78)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pik3r2 ; ZFIN pik3r2    NEW 
Molecular
reagents
All nucleic(79) cDNA(78) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000032469 (Evidence)
Ensembl Gene Model ENSMUSG00000031834 (Evidence)
Entrez Gene 18709 (Evidence)
UniGene 12945
DFCI TC1577167
DoTS DT.489669, DT.110878733
NIA Mouse Gene Index U029930
PDB 2Y3A
Consensus CDS Project CCDS22381.1
International Mouse Phenotyping Consortium Status Pik3r2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032469 VEGA Gene Model | MGI Sequence Detail 8538 C57BL/6J ±  kb
transcript OTTMUST00000080755 VEGA | MGI Sequence Detail 3165 Not Applicable 
polypeptide OTTMUSP00000043037 VEGA | MGI Sequence Detail 722 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001720 PI3 kinase, P85 regulatory subunit
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000012725 phosphatidylinositol 3-kinase regulatory subunit beta
References
(Earliest) J:36742 Pons S, et al., The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol. 1995 Aug;15(8):4453-65
(Latest) J:221890 Madhusudhan T, et al., Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy. Nat Commun. 2015;6:6496
All references(70)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory