Foxi1
Gene Detail

Symbol Name ID

Foxi1 forkhead box I1 MGI:1096329

Synonyms

Fkh10, Hfh3, HFH-3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

19.65 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:34204338-34208089 bp, - strand From VEGA annotation of GRCm38   3752 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8140  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Foxi1

Human homologs

Human Homolog		FOXI1, forkhead box I1
NCBI Gene ID		2299
neXtProt AC		NX_Q12951
Human Synonyms		FKH10, FKHL10, FREAC6, FREAC-6, HFH3, HFH-3
Human Chr (Location)		5q34; chr5:169532917-169536729 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human FOXI1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes exhibit 50% perinatal lethality and inner ear defects resulting in vestibular and cochlear dysfunction. They are deaf with signs of impaired balance, and develop renal tubular acidosis in response to a chronic acidic load. Notably, 25% of heterozygotes die at birth.

 
Human Diseases Modeled Using Mouse Foxi1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	epidermal cell fate specification, inner ear morphogenesis, ...
Component	nucleus, transcription factor complex
Function	DNA binding, DNA binding, bending, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (323)    Tissues (191)    Images (44)
Theiler Stages: 9, 15, 17, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	318
RT-PCR	5

cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(1) cDNA(38) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005407 (Evidence)
Ensembl Gene Model	ENSMUSG00000047861 (Evidence)
Entrez Gene	14233 (Evidence)
UniGene	32926
DFCI	TC1583847
DoTS	DT.55121820
NIA Mouse Gene Index	U032646
Consensus CDS Project	CCDS24539.1
International Mouse Knockout Project Status	Foxi1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005407	VEGA Gene Model | MGI Sequence Detail	3752	C57BL/6J
transcript	OTTMUST00000012053	VEGA | MGI Sequence Detail	2357	Not Applicable
polypeptide	OTTMUSP00000005586	VEGA | MGI Sequence Detail	372	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000007625	forkhead box protein I1

References

(Earliest) J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
(Latest) J:184004 Yu J, et al., Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development. 2012 May;139(10):1863-73
All references(57)

Other accession IDs

MGD-MRK-16698, MGI:1926069, MGI:99902