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Foxi1
Gene Detail
Symbol

Name
ID
Foxi1
forkhead box I1
MGI:1096329
Synonyms
Fkh10, Hfh3, HFH-3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
19.65 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:34204338-34208089 bp, - strand
From VEGA annotation of GRCm38

  3752 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8140  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Foxi1

Human
homologs
Human Homolog FOXI1, forkhead box I1
NCBI Gene ID 2299
neXtProt AC  NX_Q12951
Human Synonyms  FKH10, FKHL10, FREAC6, FREAC-6, HFH3, HFH-3
Human Chr (Location)  5q34; chr5:170105913-170109725 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human FOXI1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Homozygotes exhibit 50% perinatal lethality and inner ear defects resulting in vestibular and cochlear dysfunction. They are deaf with signs of impaired balance, and develop renal tubular acidosis in response to a chronic acidic load. Notably, 25% of heterozygotes die at birth.
 
Human Diseases Modeled Using Mouse Foxi1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Foxi1 interacts with 175 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (16 records)
Data Summary: Results (366)    Tissues (226)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 361
RT-PCR 5
cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(1) cDNA(38) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005407 (Evidence)
Ensembl Gene ModelENSMUSG00000047861 (Evidence)
Entrez Gene14233 (Evidence)
UniGene32926
DFCITC1583847
DoTSDT.55121820
NIA Mouse Gene IndexU032646
Consensus CDS ProjectCCDS24539.1
International Mouse Knockout Project StatusFoxi1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005407 VEGA Gene Model | MGI Sequence Detail 3752 C57BL/6J ±  kb
transcript OTTMUST00000012053 VEGA | MGI Sequence Detail 2357 Not Applicable 
polypeptide OTTMUSP00000005586 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007625 forkhead box protein I1
References
(Earliest) J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
(Latest) J:184004 Yu J, et al., Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development. 2012 May;139(10):1863-73
All references(55)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16698, MGI:1926069, MGI:99902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory