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Foxi1 Gene Detail
Summary
  • Symbol
    Foxi1
  • Name
    forkhead box I1
  • Synonyms
    Fkh10, Hfh3, HFH-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096329
    NCBI Gene: 14233
  • Gene Overview
    MyGene.info: FOXI1
Location & Maps
more
  • Sequence Map
    Chr11:34204338-34208089 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3752 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 19.65 cM, cytoband A5
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FOXI1, forkhead box I1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FOXI1, forkhead box I1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FKH10, FKHL10, FREAC6, FREAC-6, HFH3, HFH-3
  • Links
    NCBI Gene ID: 2299
    neXtProt AC: NX_Q12951

  • Chr Location
    5q34; chr5:170105897-170109725 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8140
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: FOXI1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Foxi1 mouse models; 2 with human FOXI1 associations

Human Disease Mouse Models
       Pendred Syndrome; PDS   OMIM: 274600 View 1 model
       Deafness, Autosomal Recessive 4, with Enlarged Vestibular Aqueduct;   OMIM: 600791
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 1 allele in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Foxi1
  • Incidental Mutations
    APF , CvDC
Homozygotes exhibit 50% perinatal lethality and inner ear defects resulting in vestibular and cochlear dysfunction. They are deaf with signs of impaired balance, and develop renal tubular acidosis in response to a chronic acidic load. Notably, 25% of heterozygotes die at birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005407 VEGA Gene Model | MGI Sequence Detail 3752 C57BL/6J ±  kb
transcript OTTMUST00000012053 VEGA | MGI Sequence Detail 2357 Not Applicable  
polypeptide OTTMUSP00000005586 VEGA | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    27 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007625 forkhead box protein I1
  • InterPro Domains
    IPR033065 Forkhead box protein I1
    IPR001766 Fork head domain
    IPR018122 Fork head domain conserved site1
    IPR030456 Fork head domain conserved site 2
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 43
    Genomic 1
    cDNA 38
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16698, MGI:1926069, MGI:99902
References
more
  • Summaries
    All 54
    Developmental Gene Expression 19
    Diseases 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:20863 Clevidence DE, et al., Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Proc Natl Acad Sci U S A. 1993 May 1;90(9):3948-52
  • Latest
    J:212428 Raft S, et al., Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear. Dev Biol. 2014 Jun 1;390(1):51-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory