Myd88
Gene Detail

Symbol Name ID

Myd88 myeloid differentiation primary response gene 88 MGI:108005

Feature Type

protein coding gene

Genetic Map

Chromosome 9

71.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:119335934-119341411 bp, - strand From VEGA annotation of GRCm38   5478 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1849  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: myeloid differentiation primary response protein MyD88
Gene Tree: Myd88

Human homologs

Human Homolog		MYD88, myeloid differentiation primary response 88
NCBI Gene ID		4615
neXtProt AC		NX_Q99836
Human Synonyms		MYD88D
Human Chr (Location)		3p22; chr3:38179969-38184513 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human MYD88

Alleles and phenotypes

All alleles(19) : Targeted(10) Gene trapped(4) Chemically induced(5)
 

Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (60 annotations)

Process	3'-UTR-mediated mRNA stabilization, cell surface receptor signaling pathway, ...
Component	cytoplasm, cytosol, ...
Function	identical protein binding, interleukin-1 receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(64)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(68) Genomic(4) cDNA(64)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016655 (Evidence)
Ensembl Gene Model	ENSMUSG00000032508 (Evidence)
Entrez Gene	17874 (Evidence)
UniGene	213003
DFCI	TC1575440, TC1594393
NIA Mouse Gene Index	U031427
Consensus CDS Project	CCDS23612.1
International Mouse Knockout Project Status	Myd88

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016655	VEGA Gene Model | MGI Sequence Detail	5478	C57BL/6J
transcript	OTTMUST00000040319	VEGA | MGI Sequence Detail	1960	Not Applicable
polypeptide	OTTMUSP00000018013	VEGA | MGI Sequence Detail	296	Not Applicable

All sequences(46) RefSeq(2) UniProt(9)

Polymorphisms

RFLP(1) : SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
InterPro	IPR017281	Myeloid differentiation primary response protein MyD88
InterPro	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology	PR:000001740	myeloid differentiation primary response protein MyD88
Protein Ontology	PR:000025771	myeloid differentiation primary response protein MyD88 (mouse)

References

(Earliest) J:36886 Lord KA, et al., Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6. Oncogene. 1990 Jul;5(7):1095-7
(Latest) J:195892 Desel C, et al., The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling. PLoS One. 2013;8(1):e53531
All references(1151)

Other accession IDs

MGD-MRK-37039