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Myd88
Gene Detail
Symbol

Name
ID
Myd88
myeloid differentiation primary response gene 88
MGI:108005
Feature Type
protein coding gene
Genetic Map
Chromosome 9
71.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:119335934-119341411 bp, - strand
From VEGA annotation of GRCm38

  5478 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1849  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYD88
Protein SuperFamily: myeloid differentiation primary response protein MyD88
Gene Tree: Myd88

Human
homologs
MYD88, myeloid differentiation primary response 88
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4615
neXtProt AC: NX_Q99836

Human Synonyms: MYD88D

Human Chr (Location): 3p22; chr3:38138478-38143022 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human MYD88

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Chemically induced (ENU)(5) Gene trapped(4) Targeted(11) Transgenic(2)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology.
 
Interactions
Myd88 interacts with 106 markers (Mir15a, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (69 annotations)
Process 3'-UTR-mediated mRNA stabilization, cell surface receptor signaling pathway, ...
Component cytoplasm, cytosol, ...
Function identical protein binding, interleukin-1 receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myd88 ; ZFIN myd88    NEW 
Molecular
reagents
All nucleic(68) Genomic(4) cDNA(64)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016655 (Evidence)
Ensembl Gene Model ENSMUSG00000032508 (Evidence)
Entrez Gene 17874 (Evidence)
UniGene 213003
DFCI TC1594393, TC1575440
NIA Mouse Gene Index U031427
Consensus CDS Project CCDS23612.1
International Mouse Phenotyping Consortium Status Myd88
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016655 VEGA Gene Model | MGI Sequence Detail 5478 C57BL/6J ±  kb
transcript OTTMUST00000040319 VEGA | MGI Sequence Detail 1960 Not Applicable 
polypeptide OTTMUSP00000018013 VEGA | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR017281 Myeloid differentiation primary response protein MyD88
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology PR:000001740 myeloid differentiation primary response protein MyD88
References
(Earliest) J:36886 Lord KA, et al., Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6. Oncogene. 1990 Jul;5(7):1095-7
(Latest) J:221359 Khairnar V, et al., CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production. Nat Commun. 2015;6:6217
All references(1349)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37039

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory