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Myd88
Gene Detail
Symbol

Name
ID
Myd88
myeloid differentiation primary response gene 88
MGI:108005
Feature Type
protein coding gene
Genetic Map
Chromosome 9
71.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:119335934-119341411 bp, - strand
From VEGA annotation of GRCm38

  5478 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1849  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: myeloid differentiation primary response protein MyD88
Gene Tree: Myd88

Human
homologs
Human Homolog MYD88, myeloid differentiation primary response 88
NCBI Gene ID 4615
neXtProt AC  NX_Q99836
Human Synonyms  MYD88D
Human Chr (Location)  3p22; chr3:38138478-38143022 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human MYD88
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Chemically induced (ENU)(5) Gene trapped(4) Targeted(10)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology.
 
Interactions
Myd88 interacts with 106 markers (Mir15a, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process 3'-UTR-mediated mRNA stabilization, cell surface receptor signaling pathway, ...
Component cytoplasm, cytosol, ...
Function identical protein binding, interleukin-1 receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(64)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(68) Genomic(4) cDNA(64)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016655 (Evidence)
Ensembl Gene ModelENSMUSG00000032508 (Evidence)
Entrez Gene17874 (Evidence)
UniGene213003
DFCITC1575440, TC1594393
NIA Mouse Gene IndexU031427
Consensus CDS ProjectCCDS23612.1
International Mouse Knockout Project StatusMyd88
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016655 VEGA Gene Model | MGI Sequence Detail 5478 C57BL/6J ±  kb
transcript OTTMUST00000040319 VEGA | MGI Sequence Detail 1960 Not Applicable 
polypeptide OTTMUSP00000018013 VEGA | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(17)
Polymorphisms
RFLP(1) : SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR017281 Myeloid differentiation primary response protein MyD88
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Protein Ontology PR:000001740 myeloid differentiation primary response protein MyD88
References
(Earliest) J:36886 Lord KA, et al., Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6. Oncogene. 1990 Jul;5(7):1095-7
(Latest) J:215261 Nagareddy PR, et al., Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab. 2014 May 6;19(5):821-35
All references(1309)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37039

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory