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Myd88 Gene Detail
Summary
  • Symbol
    Myd88
  • Name
    myeloid differentiation primary response gene 88
  • Feature Type
    protein coding gene
  • IDs
    MGI:108005
    NCBI Gene: 17874
  • Gene Overview
    MyGene.info: MYD88
Location & Maps
more
  • Sequence Map
    Chr9:119335934-119341411 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5478 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MYD88, myeloid differentiation primary response 88
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYD88, myeloid differentiation primary response 88
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MYD88D
  • Links
    NCBI Gene ID: 4615
    neXtProt AC: NX_Q99836

  • Chr Location
    3p22; chr3:38138478-38143022 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human MYD88 associations

Human Disease Mouse Models
       Macroglobulinemia, Waldenstrom, Susceptibility to, 1; WM1   OMIM: 153600
Myd88 Deficiency; MYD88D   OMIM: 612260
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    98 phenotypes from 11 alleles in 17 genetic backgrounds
    25 phenotypes from multigenic genotypes
    1227 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (ENU)
    5
  • Gene trapped
    4
  • Targeted
    11
  • Transgenic
    3
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016655 VEGA Gene Model | MGI Sequence Detail 5478 C57BL/6J ±  kb
transcript OTTMUST00000040319 VEGA | MGI Sequence Detail 1960 Not Applicable  
polypeptide OTTMUSP00000018013 VEGA | MGI Sequence Detail 296 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    101 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000001740 myeloid differentiation primary response protein MyD88
  • InterPro Domains
    IPR000488 Death domain
    IPR011029 Death-like domain
    IPR017281 Myeloid differentiation primary response protein MyD88
    IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
Molecular
Reagents
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  • All nucleic 69
    Genomic 4
    cDNA 64
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37039
References
more
  • Summaries
    All 1393
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 31
    Phenotypes 1227
  • Earliest
    J:229737 Idell S, et al., Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989 Aug;84(2):695-705
  • Latest
    J:229812 Lee BC, et al., Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88. Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E165-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory