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Myd88 Gene Detail
Summary
  • Symbol
    Myd88
  • Name
    myeloid differentiation primary response gene 88
  • Feature Type
    protein coding gene
  • IDs
    MGI:108005
    NCBI Gene: 17874
  • Gene Overview
    MyGene.info: MYD88
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:119335988-119340040 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 71.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108005
protein coding gene Chr9:119335934-119341411 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035416
protein coding gene Chr9:122098083-122103560 (-)
A/J MGP_AJ_G0035397
protein coding gene Chr9:117555482-117560953 (-)
AKR/J MGP_AKRJ_G0035330
protein coding gene Chr9:120623615-120629087 (-)
BALB/cJ MGP_BALBcJ_G0035393
protein coding gene Chr9:117432297-117437768 (-)
C3H/HeJ MGP_C3HHeJ_G0035101
protein coding gene Chr9:121086398-121091869 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035916
protein coding gene Chr9:125435131-125440608 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032798
protein coding gene Chr9:114754509-114759966 (-)
CAST/EiJ MGP_CASTEiJ_G0034404
protein coding gene Chr9:121063881-121069359 (-)
CBA/J MGP_CBAJ_G0035068
protein coding gene Chr9:130143097-130148569 (-)
DBA/2J MGP_DBA2J_G0035227
protein coding gene Chr9:116998145-117003617 (-)
FVB/NJ MGP_FVBNJ_G0035174
protein coding gene Chr9:115849348-115854996 (-)
LP/J MGP_LPJ_G0035306
protein coding gene Chr9:122445962-122452924 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035215
protein coding gene Chr9:131115286-131122663 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035935
protein coding gene Chr9:121001979-121005915 (-)
PWK/PhJ MGP_PWKPhJ_G0034110
protein coding gene Chr9:117422061-117427532 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033946
protein coding gene Chr9:121109701-121115169 (-)
WSB/EiJ MGP_WSBEiJ_G0034525
protein coding gene Chr9:120892056-120897528 (-)



Homology
more
  • Human Ortholog
    MYD88, MYD88, innate immune signal transduction adaptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYD88, MYD88, innate immune signal transduction adaptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MYD88D
  • Links
    NCBI Gene ID: 4615
    neXtProt AC: NX_Q99836
    UniProt: Q99836

  • Chr Location
    3p22.2; chr3:38138478-38143022 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human MYD88 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    99 phenotypes from 12 alleles in 19 genetic backgrounds
    25 phenotypes from multigenic genotypes
    1384 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17874 NCBI Gene Model | MGI Sequence Detail 4053 C57BL/6J ±  kb
    transcript NM_010851 RefSeq | MGI Sequence Detail 1965 Not Specified  
    polypeptide P22366 UniProt | EBI | MGI Sequence Detail 296 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000001740 myeloid differentiation primary response protein MyD88
    • InterPro Domains
      IPR000488 Death domain
      IPR011029 Death-like domain superfamily
      IPR034249 MyD88, death domain
      IPR017281 Myeloid differentiation primary response protein MyD88
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 4
      cDNA 65
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37039
    References
    more
    • Summaries
      All 1648
      Developmental Gene Expression 4
      Gene Ontology 36
      Phenotypes 1384
    • Earliest
      J:229737 Idell S, et al., Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989 Aug;84(2):695-705
    • Latest
      J:266207 Wade MF, et al., TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization. J Immunol. 2018 Oct 15;201(8):2232-2243

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory