Symbol
Name
ID

Myd88
myeloid differentiation primary response gene 88
MGI:108005

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Monoclonal immunoglobulin M proteinemia	Polyclonal elevation of IgM	Periorbital edema	Pedal edema	Elevated erythrocyte sedimentation rate	Pleural effusion	Fever
Disease(s) Associated with MYD88
lymphoplasmacytic lymphoma

Mouse Phenotypes

decreased susceptibility to diet-induced obesity

hyperglycemia

decreased circulating insulin level

abnormal circulating chemokine level

decreased circulating interleukin-10 level

decreased circulating interleukin-12b level

decreased circulating interleukin-6 level

decreased circulating tumor necrosis factor level

increased circulating tumor necrosis factor level

decreased circulating alanine transaminase level

increased circulating alanine transaminase level

decreased circulating aspartate transaminase level

increased circulating aspartate transaminase level

increased energy expenditure

abnormal glucose homeostasis

increased insulin sensitivity

abnormal cytokine level

abnormal chemokine level

decreased CXCL10 level

abnormal interferon level

abnormal tumor necrosis factor level

decreased incidence of tumors by chemical induction

increased physiological sensitivity to xenobiotic

decreased susceptibility to kidney reperfusion injury

increased susceptibility to injury

Availability

Mouse Genotype

Myd88^tm1Aki/Myd88^tm1Aki

Myd88^tm1Hlz/Myd88^tm1Hlz

Myd88^tm1Defr/Myd88^tm1Defr
Tg(Itgax-cre)1-1Reiz/0 (conditional)

Myd88^tm1Hlz/Myd88^tm1Hlz
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Myd88^tm1Jcbr/Myd88^tm1Jcbr
Tg(Nes-cre)1Kln/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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