About   Help   FAQ
Il18
Gene Detail
Symbol

Name
ID
Il18
interleukin 18
MGI:107936
Synonyms
Igif, Il-18
Feature Type
protein coding gene
Genetic Map
Chromosome 9
27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:50575273-50581837 bp, + strand
From Ensembl annotation of GRCm38

  6565 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1200  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL18
Protein SuperFamily: interleukin-18
Gene Tree: Il18

Human
homologs
IL18, interleukin 18
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3606
neXtProt AC: NX_Q14116

Human Synonyms: IGIF, IL-18, IL1F4, IL-1g

Human Chr (Location): 11q23.1; chr11:112143251-112164117 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(5) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null alleles are deficient in producing IFN-gamma in response to infectious agents and have other impairments of the immune system.
 
Human Diseases Modeled in Mice Using Il18 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Il18 interacts with 26 markers (Mir96, Mir137, Mir141, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process angiogenesis, cellular response to lipopolysaccharide, ...
Component apical plasma membrane, cytoplasm, ...
Function cytokine activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (25)    Tissues (10)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RT-PCR 16
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000039217 (Evidence)
Entrez Gene 16173 (Evidence)
UniGene 1410
DFCI TC1582495
DoTS DT.488668
NIA Mouse Gene Index U010461
Consensus CDS Project CCDS40622.1
International Mouse Phenotyping Consortium Status Il18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039217 Ensembl Gene Model | MGI Sequence Detail 6565 C57BL/6J ±  kb
transcript ENSMUST00000059081 Ensembl | MGI Sequence Detail 702 Not Applicable 
polypeptide ENSMUSP00000054591 Ensembl | MGI Sequence Detail 192 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(14) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR000975 Interleukin-1
InterPro IPR015529 Interleukin 18
Protein Ontology PR:000001376 interleukin-18
References
(Earliest) J:35492 Okamura H, et al., Cloning of a new cytokine that induces IFN-gamma production by T cells [see comments]. Nature. 1995 Nov 2;378(6552):88-91
(Latest) J:221522 Place DE, et al., Caspase-1-independent interleukin-1beta is required for clearance of Bordetella pertussis infections and whole-cell vaccine-mediated immunity. PLoS One. 2014;9(9):e107188
All references(298)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory