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Il18
Gene Detail
 Symbol
Name
ID
Il18
interleukin 18
MGI:107936
Synonyms Igif, Il-18
Feature Type protein coding gene
Genetic Map
Chromosome 9
27.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr9:50575273-50581837 bp, + strand
From Ensembl annotation of GRCm38

  6565 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1200  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: interleukin-18
Gene Tree: Il18

Human
homologs
Human Homolog IL18, interleukin 18
NCBI Gene ID 3606
neXtProt AC  NX_Q14116
Human Synonyms  IGIF, IL-18, IL1F4, IL-1g
Human Chr (Location)  11q22.2-q22.3; chr11:112143251-112164117 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null alleles are deficient in producing IFN-gamma in response to infectious agents and have other impairments of the immune system.
 
Interactions
Il18 interacts with 26 markers (Mir96, Mir137, Mir141, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process angiogenesis, cellular response to organic cyclic compound, ...
Component apical plasma membrane, cytoplasm, ...
Function cytokine activity
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (25)    Tissues (10)    Images (1)
Theiler Stages: 8, 19, 23, 24, 28
Assay TypeResults
Immunohistochemistry 9
RT-PCR 16
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000039217 (Evidence)
Entrez Gene16173 (Evidence)
UniGene1410
DFCITC1582495
DoTSDT.488668
NIA Mouse Gene IndexU010461
Consensus CDS ProjectCCDS40622.1
International Mouse Knockout Project StatusIl18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039217 Ensembl Gene Model | MGI Sequence Detail 6565 C57BL/6J ±  kb
transcript ENSMUST00000059081 Ensembl | MGI Sequence Detail 702 Not Applicable 
polypeptide ENSMUSP00000054591 Ensembl | MGI Sequence Detail 192 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(14) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(104 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR000975 Interleukin-1
InterPro IPR015529 Interleukin 18
Protein Ontology PR:000001376 interleukin-18
References (Earliest) J:35492 Okamura H, et al., Cloning of a new cytokine that induces IFN-gamma production by T cells [see comments]. Nature. 1995 Nov 2;378(6552):88-91
(Latest) J:212020 Wlodarska M, et al., NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 2014 Feb 27;156(5):1045-59
All references(294)
Other
accession IDs
MGD-MRK-36516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory