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Il18 Gene Detail
Summary
  • Symbol
    Il18
  • Name
    interleukin 18
  • Synonyms
    Igif, Il-18
  • Feature Type
    protein coding gene
  • IDs
    MGI:107936
    NCBI Gene: 16173
  • Gene Overview
    MyGene.info: IL18
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:50554827-50581840 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 27.75 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    202 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107936
protein coding gene Chr9:50554705-50581841 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034780
protein coding gene Chr9:49471812-49480766 (+)
A/J MGP_AJ_G0034761
protein coding gene Chr9:47958318-47965538 (+)
AKR/J MGP_AKRJ_G0034689
protein coding gene Chr9:48970785-48977171 (+)
BALB/cJ MGP_BALBcJ_G0034753
protein coding gene Chr9:47686299-47693122 (+)
C3H/HeJ MGP_C3HHeJ_G0034463
protein coding gene Chr9:49457325-49464617 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035273
protein coding gene Chr9:50847186-50857771 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032186
protein coding gene Chr9:47427282-47433657 (+)
CAST/EiJ MGP_CASTEiJ_G0033785
protein coding gene Chr9:49403523-49411350 (+)
CBA/J MGP_CBAJ_G0034435
protein coding gene Chr9:52661632-52668920 (+)
DBA/2J MGP_DBA2J_G0034594
protein coding gene Chr9:47823011-47829849 (+)
FVB/NJ MGP_FVBNJ_G0034535
protein coding gene Chr9:47039923-47046624 (+)
LP/J MGP_LPJ_G0034675
protein coding gene Chr9:49829012-49837598 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034578
protein coding gene Chr9:54260161-54267369 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035294
protein coding gene Chr9:48947678-48955184 (+)
PWK/PhJ MGP_PWKPhJ_G0033490
protein coding gene Chr9:47799502-47806189 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033325
protein coding gene Chr9:49262314-49268808 (+)
WSB/EiJ MGP_WSBEiJ_G0033898
protein coding gene Chr9:48954374-48960588 (+)



Homology
more
  • Human Ortholog
    IL18, interleukin 18
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL18, interleukin 18
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IGIF, IL-18, IL1F4, IL-1g
  • Links
    NCBI Gene ID: 3606
    neXtProt AC: NX_Q14116
    UniProt: Q14116

  • Chr Location
    11q23.1; chr11:112143251-112164117 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Il18 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    76 phenotypes from 6 alleles in 9 genetic backgrounds
    20 phenotypes from multigenic genotypes
    199 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles are deficient in producing IFN-gamma in response to infectious agents and have other impairments of the immune system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039217 Ensembl Gene Model | MGI Sequence Detail 27014 C57BL/6J ±  kb
    transcript ENSMUST00000214117 Ensembl | MGI Sequence Detail 860 Not Applicable  
    polypeptide ENSMUSP00000151002 Ensembl | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 22
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36516
    References
    more
    • Summaries
      All 393
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 22
      Phenotypes 199
    • Earliest
      J:35492 Okamura H, et al., Cloning of a new cytokine that induces IFN-gamma production by T cells [see comments]. Nature. 1995 Nov 2;378(6552):88-91
    • Latest
      J:265540 Tzeng TC, et al., Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):9002-9007

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory