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Il18 Gene Detail
Summary
  • Symbol
    Il18
  • Name
    interleukin 18
  • Synonyms
    Igif, Il-18
  • Feature Type
    protein coding gene
  • IDs
    MGI:107936
    NCBI Gene: 16173
  • Gene Overview
    MyGene.info: IL18
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:50554827-50581840 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27014 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 27.75 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    IL18, interleukin 18
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL18, interleukin 18
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IGIF, IL-18, IL1F4, IL-1g
  • Links
    NCBI Gene ID: 3606
    neXtProt AC: NX_Q14116
    UniProt: Q14116

  • Chr Location
    11q23.1; chr11:112143251-112164117 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Il18 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    76 phenotypes from 6 alleles in 9 genetic backgrounds
    20 phenotypes from multigenic genotypes
    196 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null alleles are deficient in producing IFN-gamma in response to infectious agents and have other impairments of the immune system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039217 Ensembl Gene Model | MGI Sequence Detail 27014 C57BL/6J ±  kb
    transcript ENSMUST00000180021 Ensembl | MGI Sequence Detail 702 Not Applicable  
    polypeptide ENSMUSP00000137193 Ensembl | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      202 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 21
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36516
    References
    more
    • Summaries
      All 387
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 21
      Phenotypes 196
    • Earliest
      J:35492 Okamura H, et al., Cloning of a new cytokine that induces IFN-gamma production by T cells [see comments]. Nature. 1995 Nov 2;378(6552):88-91
    • Latest
      J:260703 Nakamura K, et al., Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment. Cancer Cell. 2018 Apr 9;33(4):634-648.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory