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Symbol
Name
ID
Il18
interleukin 18
MGI:107936
Phenotype annotations related to homeostasis/metabolism
Darker colors indicate more annotations
Human Phenotypes
Abnormality of metabolism/homeostasis
Hyperbilirubinemia
Conjugated hyperbilirubinemia
Increased total bilirubin
Unconjugated hyperbilirubinemia
Elevated circulating hepatic transaminase concentration
Elevated gamma-glutamyltransferase level
Elevated circulating alkaline phosphatase concentration
Elevated erythrocyte sedimentation rate
Fever
Food intolerance
Acholic stools
Dark yellow urine
Hematuria
Decreased level of D-mannose in urine
Disease(s) Associated with IL18
atopic dermatitis
Behcet's disease
biliary atresia
temporal arteritis

Mouse Phenotypes
increased circulating histamine level
decreased circulating interferon-gamma level
decreased circulating interleukin-18 level
increased circulating interleukin-18 level
decreased circulating interleukin-6 level
increased circulating tumor necrosis factor level
decreased energy expenditure
abnormal nitric oxide homeostasis
decreased oxygen consumption
impaired glucose tolerance
abnormal cytokine level
abnormal interferon level
abnormal interleukin level
abnormal tumor necrosis factor level
decreased cerebral infarct size
Availability Mouse Genotype
Il18tm1Aki/Il18tm1Aki
Il18tm1Khe/Il18tm1Khe
Il18tm1Liew/Il18tm1Liew
Tg(KRT14-Il18)#Knak/0
Tg(SFTPC-Il18)AThos/0

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory