76 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il18tm1Aki/Il18+ involves: 129P2/OlaHsd	polyphagia	J:122588
Il18tm1Aki/Il18tm1Aki B6.129P2-Il18tm1Aki	abnormal gut flora balance	J:173245
	impaired neutrophil chemotaxis	J:125285
	increased susceptibility to bacterial infection	J:125285
	increased susceptibility to induced colitis	J:173245
Il18tm1Aki/Il18tm1Aki C.129P2-Il18tm1Aki	gastrointestinal hemorrhage	J:120594
	hyperchlorhydria	J:120594
	stomach inflammation	J:120594
Il18tm1Aki/Il18tm1Aki involves: 129P2/OlaHsd	abnormal macrophage physiology	J:112400
	abnormal T-helper 1 physiology	J:46514
	decreased circulating interferon-gamma level	J:46514
	decreased circulating interleukin-18 level	J:46514, J:122588
	decreased energy expenditure	J:122588
	decreased interferon-gamma secretion	J:46514
	decreased oxygen consumption	J:122588
	impaired natural killer cell mediated cytotoxicity	J:46514
	increased percent body fat/body weight	J:122588
	increased susceptibility to age related obesity	J:122588
	increased susceptibility to bacterial infection	J:112400
	increased total fat pad weight	J:122588
	increased white adipose tissue amount	J:122588
	polyphagia	J:122588
Il18tm1Aki/Il18tm1Aki involves: 129P2/OlaHsd * C57BL/6	abnormal heart left ventricle morphology	J:118183
	abnormal microglial cell morphology	J:122031
	abnormal retina vasculature morphology	J:92254
	decreased cerebral infarct size	J:124249
	decreased ventricle muscle contractility	J:118183
	retina hemorrhage	J:92254
Il18tm1Khe/Il18tm1Khe B6.129P2-Il18tm1Khe	abnormal cytokine level	J:138759
	abnormal nitric oxide homeostasis	J:138759
	decreased circulating interferon-gamma level	J:138759
	decreased circulating interleukin-6 level	J:138759
	decreased circulating interleukin-18 level	J:138759
	decreased interferon-gamma secretion	J:138759
	decreased susceptibility to bacterial infection	J:138759
	decreased tumor necrosis factor secretion	J:138759
	increased dendritic cell number	J:138759
	increased macrophage cell number	J:138759
	increased NK cell number	J:138759
Il18tm1Khe/Il18tm1Khe involves: 129P2/OlaHsd	abnormal T cell morphology	J:62263
	decreased circulating interferon-gamma level	J:62263
	decreased circulating interleukin-18 level	J:62263
	decreased susceptibility to endotoxin shock	J:62263
	increased circulating tumor necrosis factor level	J:62263
Il18tm1Liew/Il18tm1Liew involves: 129P2/OlaHsd * CD-1	abnormal interferon level	J:86621
	abnormal interleukin level	J:86621
	abnormal tumor necrosis factor level	J:86621
	increased susceptibility to bacterial infection	J:86621
	increased susceptibility to parasitic infection	J:86621
	sepsis	J:86621
Tg(CAG-cat,-Il18)#Thos/0 Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/0 involves: 129 * C57BL/6	abnormal pulmonary alveolus morphology	J:147547
	increased interferon-gamma secretion	J:147547
	interstitial pneumonia	J:147547
Tg(KRT14-Il18)#Knak/0 C57BL/6-Tg(KRT14-Il18)#Knak	abnormal T cell physiology	J:78602
	acanthosis	J:78602
	decreased T cell number	J:78602
	dermatitis	J:78602
	excessive scratching	J:78602
	increased circulating histamine level	J:78602
	increased circulating interleukin-18 level	J:78602
	increased IgE level	J:78602
	increased IgG1 level	J:78602
	increased neutrophil cell number	J:78602
	skin lesions	J:78602
Tg(SFTPC-Il18)AThos/0 B6N.Cg-Tg(SFTPC-Il18)AThos	abnormal cardiovascular system physiology	J:147547
	abnormal lung compliance	J:147547
	abnormal lung volume	J:147547
	abnormal pulmonary alveolus morphology	J:147547
	abnormal pulmonary alveolus wall morphology	J:147547
	abnormal spleen morphology	J:147547
	decreased bone mineral density	J:219136
	decreased skeletal muscle weight	J:219136
	dilated heart right ventricle	J:147547
	emphysema	J:147547
	enlarged heart	J:147547
	enlarged spleen	J:147547
	heart right ventricle hypertrophy	J:147547
	impaired glucose tolerance	J:219136
	increased interferon-gamma secretion	J:147547
	increased interleukin-13 secretion	J:147547
	increased right ventricle diastolic pressure	J:147547
	increased right ventricle systolic pressure	J:147547
	lung inflammation	J:147547
	overexpanded pulmonary alveolus	J:147547
	pulmonary hypertension	J:147547
	weight loss	J:219136