Il18^tm1Liew
Targeted Allele Detail

Summary

• Symbol: Il18^tm1Liew
• Name: interleukin 18; targeted mutation 1, Foo Yew Liew
• MGI ID: MGI:2683093
• Synonyms: IL-18^-
• Gene: Il18 Location: Chr9:50466127-50493140 bp, + strand Genetic Position: Chr9, 27.75 cM
• Alliance: Il18^tm1Liew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86621
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The last part of exon 3 including the start codon, exons 4-6, and the last part of exon 7 were all replaced with a beta-galactosidase gene and a neomycin resistance gene. Absence of gene transcript was confirmed in macrophages by RT-PCR. (J:86621)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il18 Mutation: 29 strains or lines available

References

• Original: J:86621 Wei XQ, et al., Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice. J Immunol. 1999 Sep 1;163(5):2821-8
• All: 13 reference(s)