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Lyst Gene Detail
Summary
  • Symbol
    Lyst
  • Name
    lysosomal trafficking regulator
  • Synonyms
    D13Sfk13
  • Feature Type
    protein coding gene
  • IDs
    MGI:107448
    NCBI Gene: 17101
Location & Maps
more
  • Sequence Map
    Chr13:13590409-13777440 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      187032 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 5.28 cM
  • Mapping Data
    44 experiments
Homology
more
  • Human Ortholog
    LYST, lysosomal trafficking regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LYST, lysosomal trafficking regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHS, CHS1
  • Links
    NCBI Gene ID: 1130
    neXtProt AC: NX_Q99698

  • Chr Location
    1q42.1-q42.2; chr1:235661031-235883708 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 61
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: LYST
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with Lyst mouse models; 1 with human LYST associations

Human Disease Mouse Models
       Chediak-Higashi Syndrome; CHS   OMIM: 214500 View 8 models
       Exfoliation Syndrome; XFS   OMIM: 177650 View 1 model
Storage Pool Platelet Disease   OMIM: 185050 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    17 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    92 phenotypes from 21 alleles in 24 genetic backgrounds
    48 phenotypes from multigenic genotypes
    3 images
    173 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    60
  • Chemically induced (ENU)
    12
  • Gene trapped
    34
  • Radiation induced
    1
  • Spontaneous
    9
  • Targeted
    4
  • Incidental Mutations
Homozygous mice have a phenotype similar to human Chediak-Higashi syndrome patients, exhibiting lysosomal dysfunction with resultant protein storage; diluted coat color; abnormal melanogenesis; immune cell dysfunction resulting in increased susceptibility to bacterial, viral, and parasitic infections and decreased cytotoxic activity against tumor cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019726 Ensembl Gene Model | MGI Sequence Detail 187032 C57BL/6J ±  kb
transcript ENSMUST00000110559 Ensembl | MGI Sequence Detail 11806 Not Applicable  
polypeptide ENSMUSP00000106188 Ensembl | MGI Sequence Detail 3787 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    833 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 89
    Genomic 22
    cDNA 64
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1543, MGD-MRK-25650, MGD-MRK-35919, MGI:104322
References
more
  • Summaries
    All 227
    Developmental Gene Expression 2
    Diseases 17
    Gene Ontology 25
    Phenotypes 173
  • Earliest
    J:2484 Truslove GM, Genetical studies on the skeleton of the mouse. V. 'Interfrontal' and 'parted frontals'. J Genet. 1952;51:115-122
  • Latest
    J:222308 Fairfield H, et al., Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul;25(7):948-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory