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Lyst
Gene Detail
Symbol

Name
ID
Lyst
lysosomal trafficking regulator
MGI:107448
Synonyms
D13Sfk13
Feature Type
protein coding gene
Genetic Map
Chromosome 13
5.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(44)
Sequence Map
Chr13:13590409-13777440 bp, + strand
From Ensembl annotation of GRCm38

  187032 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:61  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LYST
Gene Tree: Lyst

Human
homologs
LYST, lysosomal trafficking regulator
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1130
neXtProt AC: NX_Q99698

Human Synonyms: CHS, CHS1

Human Chr (Location): 1q42.1-q42.2; chr1:235661031-235883708 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LYST

Mutations,
alleles, and
phenotypes
All mutations/alleles(56) : Chemically induced (ENU)(9) Gene trapped(34) Radiation induced(1) Spontaneous(8) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mice have a phenotype similar to human Chediak-Higashi syndrome patients, exhibiting lysosomal dysfunction with resultant protein storage; diluted coat color; abnormal melanogenesis; immune cell dysfunction resulting in increased susceptibility to bacterial, viral, and parasitic infections and decreased cytotoxic activity against tumor cells.
 
Human Diseases Modeled in Mice Using Lyst (3)    Mutations Annotated to Human Diseases (8)    Phenotype Images(3)
Interactions
Lyst interacts with 205 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process blood coagulation, defense response to bacterium, ...
Component cell, cytoplasm, ...
Function phospholipid binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (4)    Tissues (1)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
cDNA source data(62)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lyst    NEW 
Molecular
reagents
All nucleic(89) Genomic(22) cDNA(64) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000019726 (Evidence)
Entrez Gene 17101 (Evidence)
UniGene 342337
DFCI TC1582891
DoTS DT.55151488, DT.40180972, DT.110973139, DT.103571835, DT.99855891, DT.97341967
NIA Mouse Gene Index U014557
Consensus CDS Project CCDS36597.1
International Mouse Phenotyping Consortium Status Lyst
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019726 Ensembl Gene Model | MGI Sequence Detail 187032 C57BL/6J ±  kb
transcript ENSMUST00000110559 Ensembl | MGI Sequence Detail 11806 Not Applicable 
polypeptide ENSMUSP00000106188 Ensembl | MGI Sequence Detail 3787 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(6)
Polymorphisms
All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(862 from dbSNP Build 137)    SNPs within 2kb including multiple locations(876)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000409 BEACH domain
InterPro IPR023362 PH-BEACH domain
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000010011 lysosomal-trafficking regulator
References
(Earliest) J:2484 Truslove GM, Genetical studies on the skeleton of the mouse. V. 'Interfrontal' and 'parted frontals'. J Genet. 1952;51:115-122
(Latest) J:210412 Huang P, et al., CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury. Exp Eye Res. 2013 Oct;115:131-9
All references(227)
Disease annotation references (17)
Other
accession IDs
MGD-MRK-1543, MGD-MRK-25650, MGD-MRK-35919, MGI:104322

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory