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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lyst
lysosomal trafficking regulator
MGI:107448
95 phenotypes from 24 alleles in 27 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lystbg-2Btlr/Lystbg-2Btlr
C57BL/6J-Lystbg-2Btlr 		abnormal NK cell physiology J:133617
diluted coat color J:133617
increased susceptibility to Herpesvirales infection J:133617
Lystbg-2J/Lystbg-2J
C3.Cg-Lystbg-2J/J 		abnormal gait J:15166
abnormal metastatic potential J:33522
abnormal susceptibility to infection J:147940
decreased metastatic potential J:33522
decreased Purkinje cell number J:15166
decreased susceptibility to fungal infection J:147940
impaired balance J:15166
impaired swimming J:15166
paraparesis J:15166
tremors J:15166
Lystbg-2J/Lystbg-2J
Not Specified 		abnormal eye pigmentation J:65327
decreased ear pigmentation J:65327
decreased eye pigmentation J:65327
decreased tail pigmentation J:65327
diluted coat color J:65327
Lystbg-3Btlr/Lystbg-3Btlr
C57BL/6J-Lystbg-3Btlr 		diluted coat color J:143165
Lystbg-4Btlr/Lystbg-4Btlr
C57BL/6J-Lystbg-4Btlr 		diluted coat color J:215822
Lystbg-5Btlr/Lyst+
C57BL/6J-Lystbg-5Btlr 		impaired macrophage phagocytosis J:217864
Lystbg-5Btlr/Lystbg-5Btlr
C57BL/6J-Lystbg-5Btlr 		impaired macrophage phagocytosis J:217864
Lystbg-6Btlr/Lystbg-6Btlr
C57BL/6J-Lystbg-6Btlr 		increased susceptibility to Herpesvirales infection J:220065
Lystbg-7Btlr/Lystbg-7Btlr
C57BL/6J-Lystbg-7Btlr 		diluted coat color J:231804
Lystbg-8Btlr/Lystbg-8Btlr
C57BL/6J-Lystbg-8Btlr 		diluted coat color J:234242
Lystbg-8J/Lystbg-8J
involves: DBA/2J 		abnormal coat/hair pigmentation J:30778
diluted coat color J:30778
hypopigmentation J:30778
Lystbg-9Btlr/Lystbg-9Btlr
C57BL/6J-Lystbg-9Btlr 		diluted coat color J:234265
Lystbg-10Btlr/Lystbg-10Btlr
C57BL/6J-Lystbg-10Btlr 		diluted coat color J:255206
Lystbg-10J/Lystbg-10J
involves: C57BL/6J * LT/Sv * MA/My * TF/Le 		abnormal eye pigmentation J:30778
abnormal skin pigmentation J:30778
decreased ear pigmentation J:30778
decreased eye pigmentation J:30778
decreased tail pigmentation J:30778
diluted coat color J:30778
Lystbg-11Btlr/Lystbg-11Btlr
C57BL/6J-Lystbg-11Btlr 		diluted coat color J:265211
Lystbg-11J/Lystbg-11J
involves: C57BL/6J 		abnormal coat/hair pigmentation J:30778
diluted coat color J:30778
hypopigmentation J:30778
Lystbg-14J/Lystbg-14J
C3Fe;B6-Lystbg-14J 		diluted coat color J:85200
Lystbg-16J/Lystbg-16J
B6.129S7-Rag1tm1Mom/J 		abnormal eye pigmentation J:107049
abnormal skin pigmentation J:107049
decreased ear pigmentation J:107049
decreased tail pigmentation J:107049
diluted coat color J:107049
Lystbg-18J/Lystbg-18J
B6.Cg-Lystbg-18J/Boc 		diluted coat color J:222308
Lystbg-Btlr/Lystbg-Btlr
C57BL/6J-Lystbg-Btlr 		abnormal foot pigmentation J:133616
abnormal NK cell physiology J:133616
decreased ear pigmentation J:133616
decreased tail pigmentation J:133616
diluted coat color J:133616
increased susceptibility to bacterial infection J:133616
increased susceptibility to Herpesvirales infection J:133616
Lystbg-grey/Lystbg-grey
C57BL/6-Lystbg-grey 		abnormal dermal layer morphology J:106442
abnormal dermal mast cell morphology J:106442
abnormal hair follicle melanocyte morphology J:106442
abnormal iris pigment epithelium J:106442
abnormal iris pigmentation J:106442
abnormal melanocyte morphology J:106442
abnormal melanosome morphology J:106442
abnormal retina layer morphology J:106442
abnormal retina pigment epithelium morphology J:106442
abnormal skin morphology J:106442
absent hair follicle melanin granules J:106442
diluted coat color J:106442
enlarged hair follicle melanin granules J:106442
Lystbg-J/Lystbg-J
C57BL/6J-Lystbg-J/J 		abnormal anterior uvea morphology J:173521
abnormal eye anterior chamber morphology J:173521
abnormal gait J:15166
abnormal granulocyte morphology J:34814
abnormal iridocorneal angle J:173521
abnormal iris morphology J:173521
abnormal iris pigment epithelium J:173521
abnormal iris pigmentation J:141035, J:173521
abnormal iris stroma morphology J:173521
abnormal neutrophil morphology J:34814
abnormal vestibuloocular reflex J:29747
decreased lysosomal enzyme secretion J:7327
decreased macrophage cell number J:34814
decreased platelet ADP level J:7327
decreased platelet ATP level J:7327
decreased platelet serotonin level J:7327
decreased Purkinje cell number J:15166
impaired balance J:15166
impaired natural killer cell mediated cytotoxicity J:34814
impaired swimming J:15166
increased bleeding time J:7327
paraparesis J:15166
tremors J:15166
normal vision/eye phenotype J:173521
Lystbg-Lac/Lystbg-Lac
CBA/CaLac-Lystbg-Lac 		abnormal eye pigmentation J:29745
abnormal lysosome morphology J:29745
absent NK T cells J:29745
decreased ear pigmentation J:29745
decreased eye pigmentation J:29745
decreased tail pigmentation J:29745
diluted coat color J:29745
Lystbg-Lac/Lystbg-Lac
involves: CBA/CaLac 		decreased ear pigmentation J:29745
decreased tail pigmentation J:29745
diluted coat color J:29745
Lystbg-slt/Lystbg-slt
YZ57/Ch 		abnormal choroid pigmentation J:25388
abnormal ciliary body pigmentation J:25388
abnormal iris pigmentation J:25388
abnormal retina pigmentation J:25388
delayed hair regrowth J:83269
diluted coat color J:25388
premature hair loss J:83269
Lystbg/Lystbg
B6.C3Rl-Lystbg 		abnormal eosinophil morphology J:5078
abnormal hair shaft melanin granule shape J:5078
abnormal hippocampal mossy fiber morphology J:4978
abnormal hippocampus pyramidal cell layer J:4978
abnormal lymphocyte morphology J:5078
abnormal lysosome morphology J:5338, J:5514
abnormal melanocyte morphology J:5078
abnormal melanosome morphology J:5078, J:5338
abnormal neutrophil morphology J:5078
abnormal tumor susceptibility J:6301
abnormal type II pneumocyte morphology J:110157
abnormal urine enzyme level J:5590
abnormal vestibuloocular reflex J:29747
accumulation of giant lysosomes in kidney/renal tubule cells J:5590
alveolitis J:110157
atelectasis J:110157
decreased cytotoxic T cell cytolysis J:6692
decreased lysosomal enzyme secretion J:5590
ectopic Bergmann glia cells J:4978
ectopic cerebellar granule cells J:4978
ectopic hippocampus pyramidal cells J:4978
ectopic Purkinje cell J:4978
enhanced behavioral response to xenobiotic J:29294
enlarged alveolar lamellar bodies J:110157
enlarged melanosome J:5338
impaired natural killer cell mediated cytotoxicity J:6213, J:6302
increased incidence of induced tumors J:6302
increased kidney weight J:5590
lysosomal protein accumulation J:5590
overexpanded pulmonary alveolus J:110157
pulmonary fibrosis J:110157
Lystbg/Lystbg
B6.C3Rl-Lystbg/J 		abnormal lung development J:149728
abnormal lysosome morphology J:6629
abnormal lysosome physiology J:6801
abnormal NK cell physiology J:6801
emphysema J:149728
impaired lung alveolus development J:149728
increased susceptibility to parasitic infection J:6946
Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp 		abnormal coat/hair pigmentation J:211773
abnormal iris morphology J:211773
abnormal retina morphology J:211773
decreased locomotor activity J:211773
decreased prepulse inhibition J:211773
increased fasting circulating glucose level J:211773
increased grip strength J:211773
increased mean corpuscular hemoglobin J:211773
increased mean corpuscular volume J:211773
preweaning lethality, incomplete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory