Phenotypes Associated with This Genotype

Genotype
MGI:2661024

• Allelic Composition: Lyst^bg-slt/Lyst^bg-slt
• Genetic Background: YZ57/Ch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:25388 )

• medullary pigment was highly clumped, though individual granules could be resolved in some medullary septae

• some granules were long ovals, but irregular shapes were common

• cortical granule shape varied from oval to nearly spherical

abnormal choroid pigmentation ( J:25388 )

• melanocyte pigment granules in the choroid were few in number, and were unusually large

abnormal ciliary body pigmentation ( J:25388 )

• melanocyte pigment granules in the choroid were few in number, and were unusually large

abnormal iris pigmentation ( J:25388 )

• melanocyte pigment granules in the iris were few in number, and were unusually large

abnormal retina pigmentation ( J:25388 )

• melanocyte pigment granules in the retina were few in number, and were unusually large

vision/eye

abnormal choroid pigmentation ( J:25388 )

• melanocyte pigment granules in the choroid were few in number, and were unusually large

abnormal ciliary body pigmentation ( J:25388 )

• melanocyte pigment granules in the choroid were few in number, and were unusually large

abnormal iris pigmentation ( J:25388 )

• melanocyte pigment granules in the iris were few in number, and were unusually large

abnormal retina pigmentation ( J:25388 )

• melanocyte pigment granules in the retina were few in number, and were unusually large

integument

diluted coat color ( J:25388 )

• medullary pigment was highly clumped, though individual granules could be resolved in some medullary septae

• some granules were long ovals, but irregular shapes were common

• cortical granule shape varied from oval to nearly spherical

premature hair loss ( J:83269 )

• about 5% of mice lost most of the dorsum hairs of the first coat prematurely following cessation of the first hair growth cycle

delayed hair regrowth ( J:83269 )

• about 5% of mice lost most of the dorsum hairs of the first coat prematurely following cessation of the first hair growth cycle

• an apparently normal second coat grew in these mice but the second hair growth cycle appeared somewhat delayed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Chediak-Higashi syndrome		DOID:2935	OMIM:214500	J:25388