Phenotypes Associated with This Genotype

Genotype
MGI:3779043

• Allelic Composition: Lyst^bg-2Btlr/Lyst^bg-2Btlr
• Genetic Background: C57BL/6J-Lyst^bg-2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:133617 )

• the coats of mice homozygous for this mutation are a subtle gray color

immune system

abnormal NK cell physiology ( J:133617 )

• NK cells from homozygous mutatant mice fail to degranulate following antibody stimulation of NKp46 or Ly49H receptors or after exposure to YAC-1 cells or PMA/ionomycin

increased susceptibility to Herpesvirales infection ( J:133617 )

• homozygous mutant mice are highly susceptible to infection by mouse cytomegalovirus (MCMV)

integument

diluted coat color ( J:133617 )

• the coats of mice homozygous for this mutation are a subtle gray color

hematopoietic system

abnormal NK cell physiology ( J:133617 )

• NK cells from homozygous mutatant mice fail to degranulate following antibody stimulation of NKp46 or Ly49H receptors or after exposure to YAC-1 cells or PMA/ionomycin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Chediak-Higashi syndrome		DOID:2935	OMIM:214500	J:133617