About   Help   FAQ
Hif1a
Gene Detail
Symbol

Name
ID
Hif1a
hypoxia inducible factor 1, alpha subunit
MGI:106918
Synonyms
bHLHe78, HIF1alpha, HIF-1alpha, MOP1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
31.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr12:73901375-73947530 bp, + strand
From VEGA annotation of GRCm38

  46156 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: HIF1A
Gene Tree: Hif1a

Human
homologs
HIF1A, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3091
neXtProt AC: NX_Q16665

Human Synonyms: bHLHe78, HIF1, HIF-1A, HIF-1alpha, HIF1-ALPHA, MOP1, PASD8

Human Chr (Location): 14q23.2; chr14:61695401-61748259 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(12) Targeted(14)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants die during embryonic development with severe cardiovascular malformations, neural tube defects, cephalic defects, reduced somite number and increased hypoxia.
 
Human Diseases Modeled in Mice Using Hif1a (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Hif1a interacts with 318 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (153 annotations)
Process angiogenesis, axon transport of mitochondrion, ...
Component cell, cytoplasm, ...
Function DNA binding, enzyme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (90 records)
Data Summary: Results (287)    Tissues (184)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 156
Northern blot 40
Western blot 4
RT-PCR 42
RNase protection 45
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HIF1A ; Xenbase hif1a ; ZFIN hif1aa, hif1ab    NEW 
Molecular
reagents
All nucleic(57) Genomic(21) cDNA(30) Primer pair(5) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000019740 (Evidence)
Ensembl Gene Model ENSMUSG00000021109 (Evidence)
Entrez Gene 15251 (Evidence)
DFCI TC1572109, TC1586854, TC1618922, TC1594638
DoTS DT.94238044, DT.101378714, DT.492598, DT.101703000, DT.101378720
NIA Mouse Gene Index U034072, U014085
Consensus CDS Project CCDS25977.1
International Mouse Phenotyping Consortium Status Hif1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019740 VEGA Gene Model | MGI Sequence Detail 46156 C57BL/6J ±  kb
transcript OTTMUST00000047239 VEGA | MGI Sequence Detail 4724 Not Applicable 
polypeptide OTTMUSP00000021321 VEGA | MGI Sequence Detail 836 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(307 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014887 HIF-1 alpha, transactivation domain, C-terminal
InterPro IPR001321 Hypoxia-inducible factor-1 alpha
InterPro IPR021537 Hypoxia-inducible factor, alpha subunit
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
Protein Ontology PR:000008555 hypoxia-inducible factor 1-alpha
References
(Earliest) J:12228 Obara N, et al., Expression of neural cell adhesion molecule (NCAM) during the first molar development in the mouse. Anat Embryol (Berl). 1993 Mar;187(3):209-19
(Latest) J:222038 Ameri K, et al., HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep. 2015 Feb 12;
All references(456)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35379, MGI:2144750

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory