Hif1a
Gene Detail

Symbol Name ID

Hif1a hypoxia inducible factor 1, alpha subunit MGI:106918

Synonyms

bHLHe78, HIF1alpha, HIF-1alpha, MOP1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

31.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr12:73901375-73947530 bp, + strand From VEGA annotation of GRCm38   46156 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hif1a

Human homologs

Human Homolog		HIF1A, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
NCBI Gene ID		3091
neXtProt AC		NX_Q16665
Human Synonyms		bHLHe78, HIF1, HIF-1A, HIF-1alpha, HIF1-ALPHA, MOP1, PASD8
Human Chr (Location)		14q23.2; chr14:62162119-62214977 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(22) : Targeted(12) Gene trapped(10)
 

Homozygous null mutants die during embryonic development with severe cardiovascular malformations, neural tube defects, cephalic defects, reduced somite number and increased hypoxia.

 
Human Diseases Modeled Using Mouse Hif1a (3)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (128 annotations)

Process	angiogenesis, axon transport of mitochondrion, ...
Component	cytoplasm, motile cilium, ...
Function	DNA binding, enzyme binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (72 records)
Data Summary: Results (269)    Tissues (152)    Images (25)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 19, 20, 21, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	135
Northern blot	40
RT-PCR	49
RNase protection	45

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(56) Genomic(21) cDNA(29) Primer pair(5) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000019740 (Evidence)
Ensembl Gene Model	ENSMUSG00000021109 (Evidence)
Entrez Gene	15251 (Evidence)
DFCI	TC1572109, TC1586854, TC1594638, TC1618922
DoTS	DT.101378714, DT.101378720, DT.101703000, DT.492598, DT.94238044
NIA Mouse Gene Index	U014085, U034072
Consensus CDS Project	CCDS25977.1
International Mouse Knockout Project Status	Hif1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019740	VEGA Gene Model | MGI Sequence Detail	46156	C57BL/6J
transcript	OTTMUST00000047239	VEGA | MGI Sequence Detail	4724	Not Applicable
polypeptide	OTTMUSP00000021321	VEGA | MGI Sequence Detail	836	Not Applicable

All sequences(73) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(180 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
InterPro	IPR014887	HIF-1 alpha, transactivation domain, C-terminal
InterPro	IPR001321	Hypoxia-inducible factor-1 alpha
InterPro	IPR021537	Hypoxia-inducible factor, alpha subunit
InterPro	IPR001610	PAC motif
InterPro	IPR000014	PAS domain
InterPro	IPR013767	PAS fold
InterPro	IPR013655	PAS fold-3
Protein Ontology	PR:000008555	hypoxia-inducible factor 1-alpha

References

(Earliest) J:33500 Wenger RH, et al., Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha. Biochem Biophys Res Commun. 1996 Jun 5;223(1):54-9
(Latest) J:194598 Franke K, et al., HIF-1alpha is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2alpha-induced excessive erythropoiesis. Blood. 2013 Feb 21;121(8):1436-45
All references(361)

Other accession IDs

MGD-MRK-35379, MGI:2144750