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Hif1a
Gene Detail
 Symbol
Name
ID
Hif1a
hypoxia inducible factor 1, alpha subunit
MGI:106918
Synonyms bHLHe78, HIF1alpha, HIF-1alpha, MOP1
Feature Type protein coding gene
Genetic Map
Chromosome 12
31.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr12:73901375-73947530 bp, + strand
From VEGA annotation of GRCm38

  46156 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1171  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hif1a

Human
homologs
Human Homolog HIF1A, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
NCBI Gene ID 3091
neXtProt AC  NX_Q16665
Human Synonyms  bHLHe78, HIF1, HIF-1A, HIF-1alpha, HIF1-ALPHA, MOP1, PASD8
Human Chr (Location)  14q23.2; chr14:61695401-61748259 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(10) Targeted(13)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants die during embryonic development with severe cardiovascular malformations, neural tube defects, cephalic defects, reduced somite number and increased hypoxia.
 
Human Diseases Modeled Using Mouse Hif1a (3)    Alleles Annotated to Human Diseases(1)   
Interactions
Hif1a interacts with 318 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (135 annotations)
Process angiogenesis, axon transport of mitochondrion, ...
Component cell, cytoplasm, ...
Function DNA binding, enzyme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (78 records)
Data Summary: Results (266)    Tissues (148)    Images (25)
Theiler Stages: 2, 3, 4, 5, 15, 16, 17, 19, 20, 21, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 135
Northern blot 40
Western blot 4
RT-PCR 42
RNase protection 45
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) Genomic(21) cDNA(29) Primer pair(5) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000019740 (Evidence)
Ensembl Gene ModelENSMUSG00000021109 (Evidence)
Entrez Gene15251 (Evidence)
DFCITC1572109, TC1586854, TC1594638, TC1618922
DoTSDT.101378714, DT.101378720, DT.101703000, DT.492598, DT.94238044
NIA Mouse Gene IndexU014085, U034072
Consensus CDS ProjectCCDS25977.1
International Mouse Knockout Project StatusHif1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019740 VEGA Gene Model | MGI Sequence Detail 46156 C57BL/6J ±  kb
transcript OTTMUST00000047239 VEGA | MGI Sequence Detail 4724 Not Applicable 
polypeptide OTTMUSP00000021321 VEGA | MGI Sequence Detail 836 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(6) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(307 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014887 HIF-1 alpha, transactivation domain, C-terminal
InterPro IPR001321 Hypoxia-inducible factor-1 alpha
InterPro IPR021537 Hypoxia-inducible factor, alpha subunit
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
Protein Ontology PR:000008555 hypoxia-inducible factor 1-alpha
References (Earliest) J:33500 Wenger RH, et al., Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha. Biochem Biophys Res Commun. 1996 Jun 5;223(1):54-9
(Latest) J:210247 Wang H, et al., Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nat Immunol. 2014 Apr;15(4):393-401
All references(405)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35379, MGI:2144750

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory