Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including connective tissue replacement involved in inflammatory response wound healing; positive regulation of DNA-templated transcription; and positive regulation of mitophagy. Acts upstream of or within several processes, including circulatory system development; epithelial cell differentiation; and negative regulation of apoptotic process. Located in motile cilium and nuclear speck. Part of euchromatin. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Used to study glycogen storage disease V and glycogen storage disease VII. Human ortholog(s) of this gene implicated in carcinoma (multiple); diabetic retinopathy; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).