About   Help   FAQ
Adra1d Gene Detail
Summary
  • Symbol
    Adra1d
  • Name
    adrenergic receptor, alpha 1d
  • Synonyms
    Adra1, Adra-1, Adra1a, alpha1D-AR, Gpcr8
  • Feature Type
    protein coding gene
  • IDs
    MGI:106673
    NCBI Gene: 11550
  • Gene Overview
    MyGene.info: ADRA1D
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131545850-131562283 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.50 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106673
protein coding gene Chr2:131545357-131562285 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026532
protein coding gene Chr2:135087660-135104132 (-)
A/J MGP_AJ_G0026496
protein coding gene Chr2:129595853-129612279 (-)
AKR/J MGP_AKRJ_G0026471
protein coding gene Chr2:133329442-133345892 (-)
BALB/cJ MGP_BALBcJ_G0026508
protein coding gene Chr2:129984861-130001298 (-)
C3H/HeJ MGP_C3HHeJ_G0026251
protein coding gene Chr2:133792647-133809109 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026953
protein coding gene Chr2:139224563-139241004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024330
protein coding gene Chr2:124332475-124348695 (-)
CAST/EiJ MGP_CASTEiJ_G0025712
protein coding gene Chr2:134064192-134080513 (-)
CBA/J MGP_CBAJ_G0026231
protein coding gene Chr2:144417967-144434435 (-)
DBA/2J MGP_DBA2J_G0026365
protein coding gene Chr2:128986705-129003036 (-)
FVB/NJ MGP_FVBNJ_G0026329
protein coding gene Chr2:127613137-127630575 (-)
LP/J MGP_LPJ_G0026470
protein coding gene Chr2:135308469-135324924 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026349
protein coding gene Chr2:148231241-148247649 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027008
protein coding gene Chr2:133312783-133329251 (-)
PWK/PhJ MGP_PWKPhJ_G0025448
protein coding gene Chr2:128569147-128585544 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025250
protein coding gene Chr2:132470174-132486660 (-)
WSB/EiJ MGP_WSBEiJ_G0025786
protein coding gene Chr2:134218944-134235571 (-)



Homology
more
  • Human Ortholog
    ADRA1D, adrenoceptor alpha 1D
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADRA1D, adrenoceptor alpha 1D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2
  • Links
    NCBI Gene ID: 146
    neXtProt AC: NX_P25100
    UniProt: P25100

  • Chr Location
    20p13; chr20:4220631-4249012 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display hypotension or reduced rearing behavior in a novel environment, decreased wheel-running activity during the night, and reduced hyperlocomotion after amphetamine administration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027335 Ensembl Gene Model | MGI Sequence Detail 16434 C57BL/6J ±  kb
    transcript ENSMUST00000103184 Ensembl | MGI Sequence Detail 1899 Not Applicable  
    polypeptide ENSMUSP00000099473 Ensembl | MGI Sequence Detail 562 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 9
      Primer pair 1
      Other 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-1134, MGD-MRK-1139, MGD-MRK-16339, MGD-MRK-28037, MGD-MRK-35132, MGI:104746, MGI:99561
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:230291 Kordasz ML, et al., Role of alpha(1)-adrenoceptor subtypes in pupil dilation studied with gene-targeted mice. Invest Ophthalmol Vis Sci. 2014 Dec;55(12):8295-301

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory